Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations 1253A/H310A/H435A in the Fc-region, and methods of using the same.

Abstract: A device for clamping and holding medical hose lines includes a hose clamp with two clamping legs on opposite sides of a passage. The passage is configured to receive a first hose portion. The clamping legs are movable between a clamping position, in which the clamping legs constrict the passage and clamp the first hose portion, and a release position in which the constriction is eliminated. The device also includes a holding clip connected to the hose clamp. The holding clip has two arms arranged opposite one another bordering a recess. The recess is configured to receive at least one second hose portion to be held between the arms. The arms are movable relative to one another between an open position, in which the arms expose a slot opening radially into the recess, and a holding position in which the slot is closed or at least constricted.

Abstract: The present disclosure relates to isoxazolidines and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase 1.

Abstract: A dialysis system with post dialysis aseptic blood return including a fluid source, a dialyzer, a pump, a venous line, an arterial line, a bridge line coupled between the venous line and the arterial line, and a fluid source line coupled between the fluid source and a fluid port of the arterial line downstream for the bridge line. Aseptic blood return after dialysis is performed by blocking the arterial line between the bridge line and the fluid port, unblocking the bridge line, unblocking the fluid source line, and operating the pump in a forward direction to produce fluid flow from the fluid source, through the dialyzer, and through the bridge line to force venous blood in the venous line toward the patient venous access and arterial blood in the arterial line toward the patient arterial access.

Abstract: A dialyzer for an extracorporeal blood treatment includes an elongated, preferably cylindrical dialyzer housing, and at least one dialysis membrane that separates an internal space of the dialyzer housing into a dialysis liquid chamber and a blood chamber. The dialysis liquid chamber has a dialysis liquid supply port and a dialysis liquid discharge port. The blood chamber has a blood supply port and a blood discharge port. The dialyzer includes an additional ventilation outlet for ventilating the blood chamber. The additional ventilation outlet is located with respect to a blood flow direction in the blood discharge port between an exit area of the blood discharge port and the dialysis liquid supply port. A corresponding dialysis device includes a ventilation outlet on a dialyzer housing or on a hose connected to a blood discharge port.

Abstract: The invention relates to a gripper apparatus for a cannulation robot and for gripping a cannula having a cannula holder. The gripper apparatus comprises two gripper elements and a moving device. The two gripper elements can be moved relative to each other and work in concert to grip the cannula holder. The moving device is designed to move the two gripper elements relative to each other and at least one of the gripper elements relative to the cannula holder. The gripper apparatus can thereby be brought into a gripping state, in which at least one of the gripper elements is engaged with the cannula holder, by means of the moving device.

Abstract: An apparatus is provided for producing and/or disengaging a fluid flow-capable medical threaded connection. The connection can be a Luer lock connection. The apparatus includes a first receiving device for receiving a first connecting element, and a second receiving device for receiving a second connecting element. The first receiving device and the second receiving device are rotatable relative to each other about a common screwing axis, and displaceable relative to each other along the screwing axis. The apparatus is designed to relatively move the first receiving device and the second receiving device toward and away from each other such that the first connecting element and the second connecting element can be screwed together or disengaged. An associated connecting element can be introduced into the first receiving device and/or into the second receiving device, in a radial direction relative to the screwing axis. A method is also provided.

Abstract: A device for clamping and holding medical hose lines includes a hose clamp with two clamping legs on opposite sides of a passage. The passage is configured to receive a first hose portion. The clamping legs are movable between a clamping position, in which the clamping legs constrict the passage and clamp the first hose portion, and a release position in which the constriction is eliminated. The device also includes a holding clip connected to the hose clamp. The holding clip has two arms arranged opposite one another bordering a recess. The recess is configured to receive at least one second hose portion to be held between the arms. The arms are movable relative to one another between an open position, in which the arms expose a slot opening radially into the recess, and a holding position in which the slot is closed or at least constricted.

Abstract: An extracorporeal blood treatment machine for carrying out a blood treatment including a machine front on which a hollow fiber filter module is arranged in a horizontal position, which hollow fiber filter module includes a cylindrical housing, a blood chamber having a blood inlet nozzle and a blood outlet nozzle and a solution chamber having a solution inlet nozzle extending transversely to the longitudinal direction of the hollow fiber filter module and a solution outlet nozzle extending transversely to the longitudinal direction of the hollow fiber filter module, the solution chamber being semi-permeably communicated at least in portions with the blood chamber, wherein a height potential is present in the horizontal position between the solution inlet nozzle and the solution outlet nozzle so that drainage of solution is enabled via one of the solution nozzles and evacuation of air bubbles is enabled via an other of the solution nozzles.

Abstract: A blood treatment device for extracorporeal blood treatment and a method for monitoring the fill level of blood with the blood treatment device. The device includes at least one blood conducting system and at least one chamber container for separating bubbles from the blood to be treated. The device further includes a blood pumping device designed to pump the blood and generate pressure pulses with a predefined frequency in the blood conducting system. The blood treatment device additionally has at least one pressure detection sensor for capturing the pressure pulse introduced by the blood pumping device and a data processing unit designed to derive a fill level parameter from the pressure pulse captured and to modify the state of an information signal as a function of the fill level parameter. At least one alarm device is activated as a function of the state of the information signal.

Abstract: A blood circulation system for an extracorporeal blood treatment machine includes: an arterial circulation section; a venous circulation section; a dynamic bubble trap; and an air separator. The blood circulation system conducts blood, during the operation of a blood pump of the extracorporeal blood treatment machine, from a patient to a dialysis unit and from the dialysis unit to the patient. The blood circulation system also includes a recirculation or branch line connected to the bubble trap in order to return part of the blood that flows into the bubble trap into the blood circulation system, upstream of the bubble trap. An extracorporeal blood treatment machine includes the blood circulation system.

Abstract: The invention relates to a detection apparatus and a method for detecting and manipulating a blood vessel under the skin of part of the body of a patient, which comprises a treatment chamber for accommodating the body part, a data processing control device, a vascular structure measuring device for detecting the position and/or dimensions of vascular structure data of the blood vessel in the treatment chamber by measurement, a vascular manipulation device for changing the position and/or dimension of the blood vessel, wherein the control device is designed to control the vascular manipulation device as a function of the vascular structure data.

Abstract: The invention relates to a cannulation robot for the automated affixing of a cannula to a patient. The cannulation robot comprises a fixing apparatus for affixing the cannula to the patient by means of an adhesive carrier. The cannulation robot comprises a positioning device designed to position a cannula holder of the cannula to an area of the patient's skin. The cannulation robot comprises an actuator device for a guide means, wherein the guide means is designed to guide the adhesive carrier to said skin area. The actuator device is designed to activate the guide means and thereby move the adhesive carrier by means of the guide means toward the skin area, wherein the adhesive carrier contacts the skin area as a result of the movement and adheres to same as well as is disposed such that it is connected to the cannula at least after being adhered.

Abstract: A display device of a dialysis machine for displaying various parameters containing a quantity of patient-related treatment parameters and a quantity of clinic-related CIS parameters. The display device has one display and an input unit to individually modify the quantity of patient-related treatment parameters or the quantity of clinic-related CIS parameters. The display includes a display area divided into a first display panel and a second display panel. The display can be switched to a treatment configuration in which the quantity of patient-related treatment parameters is displayed exclusively in the first display panel and the quantity of clinic-related CIS parameters is displayed exclusively in the second display panel. The display can also be switched to a CIS configuration in which the quantity of patient-related treatment parameters is displayed exclusively in the second display panel and the quantity of clinic-related CIS parameters is displayed exclusively in the first display panel.

Abstract: A pressure-measuring assembly for measuring the internal line pressure of a line system of an extracorporeal blood treatment machine. The assembly includes a pressure sensor that is connectable to a pressure receiver by a rigid, bending-resistant fluid line. The pressure receiver is connected or connectable to the line system. The pressure sensor converts a fluid pressure signal from the fluid line into an electrical signal. An electrical line connects the pressure sensor to electronics to process the electrical signal. A retainer directly or indirectly retains the pressure sensor and forms, at least in parts, an inner channel, in which the electrical line is led. Alternatively, the retainer is a substantially plastically curvable bar which has, at one axial end portion, a fastening device for mounting on a stationary base and, at the other axial end portion, an articulation site for the pressure sensor or the pressure receiver.

Abstract: The invention relates to a method and an automatic disinfection machine for the controlled disinfection of the skin of a patient comprising a treatment chamber for accommodating the body part with the skin to be disinfected; an electrically controllable disinfecting device for disinfecting the skin, a recording device for recording the disinfection of the skin in the form of disinfection data, a data processing control device for controlling the disinfecting device and the recording device. The control device is thereby designed to effect the disinfection of the skin by controlling the disinfecting device, record the disinfection of a skin section of the skin in the form of disinfection data by controlling the recording device.

Abstract: An extracorporeal blood treatment machine includes a blood treatment device, a conveying device for conveying blood through the blood treatment device, and a connection mask designed to interchangeably receive a tube set in a predefined arrangement. The tube set has pressure-monitoring lines that branch off from the tube set and can be connected to pressure sensor connections located on the connection mask. The pressure sensor connections are spaced apart and positioned so as to match the tube set such that, when the tube set is mounted in the predefined arrangement on the connection mask, each pressure-monitoring line, owing to its limited length and the predefined arrangement of the associated branch on the blood treatment machine, can be connected exclusively to only one of the pressure sensor connections. A corresponding tube set is used with the extracorporeal blood treatment machine.

Abstract: A dialyzer for an extracorporeal blood treatment includes an elongated, preferably cylindrical dialyzer housing, and at least one dialysis membrane that separates an internal space of the dialyzer housing into a dialysis liquid chamber and a blood chamber. The dialysis liquid chamber has a dialysis liquid supply port and a dialysis liquid discharge port. The blood chamber has a blood supply port and a blood discharge port. The dialyzer includes an additional ventilation outlet for ventilating the blood chamber. The additional ventilation outlet is located with respect to a blood flow direction in the blood discharge port between an exit area of the blood discharge port and the dialysis liquid supply port. A corresponding dialysis device includes a ventilation outlet on a dialyzer housing or on a hose connected to a blood discharge port.

Abstract: A vascular access implant and system for connecting an intracorporeal blood circulation to an extracorporeal blood circulation includes an arterial fluid line for connection to a patient's artery and a venous fluid line for connection to a patient's vein. A controllable artery-vein-connection between the arterial fluid line and venous fluid line controls fluid flow between the arterial fluid line and venous fluid line. An arterial port is in fixed fluid connection with the arterial fluid line for coupling to and decoupling from a first hose of the extracorporeal blood circulation. A venous port is in fixed fluid connection with the venous fluid line for coupling to and decoupling from a second hose of the extracorporeal blood circulation.

Abstract: A display device of a dialysis machine for displaying various parameters containing a quantity of patient-related treatment parameters and a quantity of clinic-related CIS parameters. The display device has one display and an input unit to individually modify the quantity of patient-related treatment parameters or the quantity of clinic-related CIS parameters. The display includes a display area divided into a first display panel and a second display panel. The display can be switched to a treatment configuration in which the quantity of patient-related treatment parameters is displayed exclusively in the first display panel and the quantity of clinic-related CIS parameters is displayed exclusively in the second display panel. The display can also be switched to a CIS configuration in which the quantity of patient-related treatment parameters is displayed exclusively in the second display panel and the quantity of clinic-related CIS parameters is displayed exclusively in the first display panel.