Patents by Inventor Uwe Rothhaar
Uwe Rothhaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240009080Abstract: A pharmaceutical container includes an inner surface and an outer surface. At least part of the inner surface is coated with a coating to form a coated inner surface. On the coated inner surface the container, based on negative mode Time-of-Flight-Secondary Ion Mass Spectrometry (ToF-SIMS) data, has a relative lipid nanoparticle (LNP)-incubated Multivariate Curve Resolution (MCR) score ratio of lipid factor1 of less than 0.67.Type: ApplicationFiled: September 21, 2023Publication date: January 11, 2024Applicant: SCHOTT Pharma AG & Co. KGaAInventors: Matthias Bicker, Christoph Brüning, Anne Spende, Flor Toledo Rodríguez, Michaela Klause, Uwe Rothhaar, Tanja Woywod, Eveline Rudigier-Voigt, Jovana Djordjevic-Reiss, Sylvia Biedenbender, Harmut Bauch
-
Publication number: 20230310271Abstract: A method of forming a glass vial includes: locally heating one end of a glass tube; removing the locally heated end of the glass tube to form the glass vial having a closed base; and further forming the base of the glass vial, the further forming including generating a purge gas flow within the formed glass vial with the aid of a purge gas.Type: ApplicationFiled: May 25, 2023Publication date: October 5, 2023Applicant: SCHOTT Pharma AG & Co. KGaAInventors: Robert Frost, Uwe Rothhaar, Florence Buscke, Bernhard Hladik
-
Patent number: 11707412Abstract: A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.Type: GrantFiled: August 13, 2020Date of Patent: July 25, 2023Assignee: SHOTT Pharma AG & Co. KGaAInventors: Robert Frost, Uwe Rothhaar, Florence Buscke, Bernhard Hladik
-
Publication number: 20220315284Abstract: A coated glass container includes: a glass surface; and a coating that coats at least part of the glass surface to form a coated glass surface. The coating includes at least one layer. The coated glass container fulfills the following parameter: leaching of [Na] ions after an alkaline treatment is 10 mg/l or less [Na] ions.Type: ApplicationFiled: March 25, 2022Publication date: October 6, 2022Applicant: Schott AGInventors: Tanja Woywod, Eveline Rudigier-Voigt, Jovana Djordjevic-Reiß, Uwe Rothhaar, Michaela Klause, Sylvia Biedenbender, Hartmut Bauch
-
Publication number: 20220306527Abstract: A coated glass element includes: a glass surface; and a coating that coats at least part of the glass surface. The coating includes at least one layer. The at least one layer of the coating fulfills the following parameter: [Si2C5H15O2?]20/[Si2C5H15O2?]80?1.0. [Si2C5H15O2?]20 are counts of [Si2C5H15O2] ions, measured by a time-of-flight secondary ion mass spectrometry (TOF-SIMS), at 20% of a time a sputter gun beam needs to reach the glass surface and [Si2C5H15O2?]80 are counts of [Si2C5H15O2?]80 ions, measured by a TOF-SIMS, at 80% of a time a sputter gun beam needs to reach the glass surface.Type: ApplicationFiled: March 25, 2022Publication date: September 29, 2022Applicant: Schott AGInventors: Tanja Woywod, Eveline Rudigier-Voigt, Jovana Djordjevic-Reiss, Uwe Rothhaar, Michaela Klause, Sylvia Biedenbender, Hartmut Bauch
-
Publication number: 20220306525Abstract: A coated glass element includes: a glass surface and a coating that coats at least part of the glass surface. The coating has at least one layer. The at least one layer of the coating fulfills the following parameter: [Al+]80/[Al+]20?1.8. [Al+]20 are counts of [Al+] ions, measured by a time-of-flight secondary ion mass spectrometry (TOF-SIMS), at 20% of a time a sputter gun beam needs to reach the glass surface and [Al+]80 are counts of [Al+] ions, measured by a TOF-SIMS, at 80% of a time a sputter gun beam needs to reach the glass surface.Type: ApplicationFiled: March 25, 2022Publication date: September 29, 2022Applicant: Schott AGInventors: Tanja Woywod, Eveline Rudigier-Voigt, Jovana Djordjevic-Reiß, Uwe Rothhaar, Michaela Klause, Sylvia Biedenbender, Hartmut Bauch
-
Publication number: 20220306341Abstract: A coated container includes: a container having a surface; and a coating applied to at least part of the surface to form a coated surface. Leaching of at least one of one or more types of ions or one or more types of compounds is determined by performing an alkaline treatment on at least part of the coated surface to obtain an alkaline treated surface and performing an acidic treatment on at least part of the alkaline treated surface to obtain an acidic treated surface. The leaching of the at least one of one or more types of ions or one or more types of compounds from the coated surface is 5.00 mg/l or less.Type: ApplicationFiled: March 25, 2022Publication date: September 29, 2022Applicant: Schott AGInventors: Uwe Rothhaar, Michaela Klause, Florence Buscke, Sebastian Brechler, Eveline Rudigier-Voigt, Jovana Djordjevic-Rei?, Hartmut Bauch, Sylvia Biedenbender
-
Publication number: 20200399165Abstract: A glass vial including a boron-containing multicomponent glass includes constituents and is partially filled with a pharmaceutical ingredient formulation having a pH in a range from 5 to 9. The glass vial has a total volume of <4.5 mL, a filling level of the glass vial with the formulation is not more than 0.25, and an inner wall of the glass vial has chemical resistance to leaching-out of at least one of the constituents of the multicomponent glass. A ratio of a concentration of a leached-out constituent at a fill volume of 0.5 mL and a concentration of the leached-out constituent at a fill volume of 2 mL is not more than 3 and a ratio between a concentration of the leached-out constituent at a fill volume of 1 mL and the concentration of the leached-out constituent at a fill volume of 2 mL is not more than 2.Type: ApplicationFiled: August 13, 2020Publication date: December 24, 2020Applicant: SCHOTT AGInventors: Robert Frost, Uwe Rothhaar, Florence Buscke, Bernhard Hladik
-
Publication number: 20200368108Abstract: A glass vial includes a base including a boron-containing multicomponent glass and a vial opening and holds a liquid active pharmaceutical ingredient formulation. The glass vial has a total volume of <4.5 mL. A filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over the measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Applicant: SCHOTT AGInventors: Robert Frost, Uwe Rothhaar, Florence Buscke, Bernhard Hladik
-
Patent number: 9322766Abstract: A rapid test method for evaluating the delamination in glass packaging is provided. The method includes exposing the glass packaging means to an atmosphere consisting of steam in order to form a corrosion zone; and subsequently carrying out at least one other step. The other step includes: visualizing the corrosion zone using a light microscope; visualizing the corrosion zone by a staining process with a subsequent inspection process; or removing glass components in ultrapure water and quantifying the removed glass components. The rapid test method provides a conclusion about whether a glass packaging exhibits a tendency to delaminate or not in a simple and reliable manner and in a relatively short time span.Type: GrantFiled: October 24, 2012Date of Patent: April 26, 2016Assignee: SCHOTT AGInventors: Volker Scheumann, Michaela Klause, Uwe Rothhaar
-
Patent number: 9107805Abstract: A container for pharmaceutical and medical applications made from glass, preferably from a borosilicate glass. The container is formed in the shape of a hollow body open at both its ends with a cylindrical portion having a wall thickness tolerance of maximally ±0.2 mm. The borosilicate glass has a nominal boron content that drops by less than 40% relative to the nominal value at all of the surfaces of the container.Type: GrantFiled: March 28, 2013Date of Patent: August 18, 2015Assignee: SCHOTT AGInventors: Andreas Langsdorf, Juergen Thuerk, Aurel Kunz, Ulrich Lange, Joachim Kuester, Bernd Loeffelbein, Marcus Meinefeld, Uwe Rothhaar, Axel Ohlinger
-
Publication number: 20140240694Abstract: A rapid test method for evaluating the delamination in glass packaging is provided. The method includes exposing the glass packaging means to an atmosphere consisting of steam in order to form a corrosion zone; and subsequently carrying out at least one other step. The other step includes: visualizing the corrosion zone using a light microscope; visualizing the corrosion zone by a staining process with a subsequent inspection process; or removing glass components in ultrapure water and quantifying the removed glass components. The rapid test method provides a conclusion about whether a glass packaging exhibits a tendency to delaminate or not in a simple and reliable manner and in a relatively short time span.Type: ApplicationFiled: October 24, 2012Publication date: August 28, 2014Inventors: Volker Scheumann, Michaela Klause, Uwe Rothhaar
-
Patent number: 8673406Abstract: The invention relates to a method for the plasma treatment of glass surfaces, the metal component, in particular the alkali and/or alkaline-earth metal component in the superficial region of the substrate being reduced by a plasma treatment of a substrate.Type: GrantFiled: February 28, 2007Date of Patent: March 18, 2014Assignee: Schott AGInventors: Matthias Bicker, Uwe Rothhaar, Robert Hormes, Bernd Hanser, Manfred Lohmeyer, Stefan Bauer
-
Patent number: 8464553Abstract: The invention proposes a process for the production of a container for pharmaceutical and medical applications made from glass, preferably from a borosilicate glass, wherein the container is produced by a press-blow process where the container is initially preformed in a pressing step, by making a ram press a dispensed glass drop into a mold that is open at its bottom, and where the parison so produced is given its final form by a subsequent blowing step.Type: GrantFiled: February 5, 2010Date of Patent: June 18, 2013Assignee: Schott AGInventors: Andreas Langsdorf, Juergen Thuerk, Aurel Kunz, Ulrich Lange, Joachim Kuester, Bernd Loeffelbein, Marcus Meinefeld, Uwe Rothhaar, Axel Ohlinger
-
Patent number: 8158225Abstract: The invention proposes a process for the production of a container made from glass, in the form of a hollow body open on both ends for pharmaceutical and medical applications, in particular in the form of a syringe barrel, where a glass drop (14) is dispensed from a melting unit, is placed into a mold (12) that is driven to rotate, and is formed by the effect of the centrifugal force, the mold being driven at a rotational speed of at least 5000 rpm, preferably approximately 50000 rpm.Type: GrantFiled: February 3, 2010Date of Patent: April 17, 2012Assignee: Schott AGInventors: Andreas Langsdorf, Juergen Thuerk, Aurel Kunz, Ulrich Lange, Joachim Kuester, Bernd Loeffelbein, Marcus Meinefeld, Uwe Rothhaar, Axel Ohlinger
-
Patent number: 8067070Abstract: The invention relates to a composite material (1), to containers made therefrom and to a method for producing the composite material (1), which comprises a substrate (2) and a coating (3) on the substrate (2), wherein the coating (3) provides at least a first region (31) facing the substrate (2) and at least a second region (32) facing away the substrate (2), and wherein the first region (31) comprises a barrier layer (4) and the second region (32) a passivation layer (5).Type: GrantFiled: October 11, 2007Date of Patent: November 29, 2011Assignee: Schott AGInventors: Juergen Klein, Tanja Woywod, Stephan Behle, Uwe Rothhaar
-
Publication number: 20100203269Abstract: The invention proposes a process for the production of a container made from glass, in the form of a hollow body open on both ends for pharmaceutical and medical applications, in particular in the form of a syringe barrel, where a glass drop (14) is dispensed from a melting unit, is placed into a mold (12) that is driven to rotate, and is formed by the effect of the centrifugal force, the mold being driven at a rotational speed of at least 5000 rpm, preferably approximately 50000 rpm.Type: ApplicationFiled: February 3, 2010Publication date: August 12, 2010Inventors: Andreas LANGSDORF, Juergen Thuerk, Aurel Kunz, Ulrich Lange, Joachim Kuester, Bernd Loeffelbein, Marcus Meinefeld, Uwe Rothhaar, Axel Ohlinger
-
Publication number: 20100203270Abstract: The invention proposes a process for the production of a container for pharmaceutical and medical applications made from glass, preferably from a borosilicate glass, wherein the container is produced by a press-blow process where the container is initially preformed in a pressing step, by making a ram press a dispensed glass drop into a mold that is open at its bottom, and where the parison so produced is given its final form by a subsequent blowing step.Type: ApplicationFiled: February 5, 2010Publication date: August 12, 2010Inventors: Andreas LANGSDORF, Juergen Thuerk, Aurel Kunz, Ulrich Lange, Joachim Kuester, Bernd Loeffelbein, Marcus Meinefeld, Uwe Rothhaar, Axel Ohlinger
-
Publication number: 20100089097Abstract: The invention discloses a method for the production of packaging made from borosilicate glass for pharmaceutical products and medical products comprising the steps of: providing a glass tube made from a borosilicate base glass, generating a temporary interface layer on an inner surface of the glass tube, hot-forming the glass tube at a temperature above Tg, and cooling down the glass tube to room temperature.Type: ApplicationFiled: October 7, 2009Publication date: April 15, 2010Inventors: Heike Brack, Uwe Rothhaar, Stephan Tratzky, Juergen Thuerk
-
Publication number: 20080090039Abstract: The invention relates to a composite material (1), to containers made therefrom and to a method for producing the composite material (1), which comprises a substrate (2) and a coating (3) on the substrate (2), wherein the coating (3) provides at least a first region (31) facing the substrate (2) and at least a second region (32) facing away the substrate (2), and wherein the first region (31) comprises a barrier layer (4) and the second region (32) a passivation layer (5).Type: ApplicationFiled: October 11, 2007Publication date: April 17, 2008Applicant: Schott AGInventors: Juergen Klein, Tanja Woywod, Stephan Behle, Uwe Rothhaar