Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, including a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (Ti) of the coolant (3) delivered to the cooling chamber (I), and a regulator (11) for regulating the temperature. The regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.

Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, including a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (Ti) of the coolant (3) delivered to the cooling chamber (I), and a regulator (11) for regulating the temperature. The regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.

Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.

Abstract: The invention relates to a process for treating a substantially water-containing amino-functional, polymeric catalyst precursor while retaining the inner porous structure thereof and the outer spherical form thereof to form a catalyst, in which the catalyst precursor is treated at mild temperatures and under reduced pressure to prepare a catalyst having a water content below 2.5% by weight. The process is preferably integrated into an industrial scale process for preparing dichlorosilane, monosilane, silane, or solar silicon or semiconductor silicon from silanes.

Abstract: The invention relates to a cryoapparatus for freezing and/or thawing a sample (1), especially in the cryopreservation of a biological sample (1), with a coolable cooling space (3) and with a sample container (10) arranged in the cooling space (3) for temporarily receiving the sample (1) when freezing or thawing the sample (1). It is suggested that the sample container (10) can be tempered separately from the cooling space. Furthermore, the invention includes an associated operating method.

Abstract: The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.

Abstract: The invention relates to a trunk of a motor vehicle, having a goods rail (14) which is oriented approximately in the direction of the longitudinal axis (L) of the vehicle and is intended for fixing goods to be transported. In the event of a rear impact, penetration into a seat region arranged in front of the trunk is prevented by reducing the effective of the goods rail (14), by the goods rail (14) being composed of at least two partial rails (15, 16). According to the invention, the separating plane (17) between the partial rails (15, 16) runs in an obliquely inclined manner.

Abstract: The invention relates to a cryoapparatus for freezing and/or thawing a sample (1), especially in the cryopreservation of a biological sample (1), with a coolable cooling space (3) and with a sample container (10) arranged in the cooling space (3) for temporarily receiving the sample (1) when freezing or thawing the sample (1). It is suggested that the sample container (10) can be tempered separately from the cooling space. Furthermore, the invention comprises an associated operating method.

Abstract: Dual NK2/NK3-antagonists corresponding to formula I: and physiologically compatible salts of such compounds in which X and R1 to R5 have specific defined meanings, pharmaceutical compositions containing such compounds, methods of using such compounds to treat or inhibit disorders mediated by tachykinin receptors, and a process for preparing such compounds.

Abstract: The invention relates to a cooling device (1) for cooling an item to be cooled, especially for use in the examination, handling and processing of cryogenic samples. The device includes a cooling compartment (3) for receiving the item to be cooled, an inner wall defining the cooling compartment (3), an outer wall, a space between the outer wall and the inner wall, and a coolant feed line (11) for feeding a coolant. According to the invention, the coolant feed line (11) leads into the space between the inner wall and the outer wall and feeds the coolant into the space, the inner wall being permeable for the coolant.

Abstract: The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.

Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.

Abstract: The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.

Abstract: The invention relates to a trunk of a motor vehicle, having a goods rail (14) which is oriented approximately in the direction of the longitudinal axis (L) of the vehicle and is intended for fixing goods to be transported. In the event of a rear impact, penetration into a seat region arranged in front of the trunk is prevented by reducing the effective of the goods rail (14), by the goods rail (14) being composed of at least two partial rails (15, 16). According to the invention, the separating plane (17) between the partial rails (15, 16) runs in an obliquely inclined manner.

Abstract: The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.

Abstract: The invention relates to an Ultrasound Sensor, especially for a vehicle and the passenger compartment thereof, comprising a can-shaped housing, a housing base, a housing closure and a sensor element arranged at the base inside the housing, and in the area of the housing closure there is arranged a contact device which is attachable, in locally fixed fashion, inside housing; the contact device presenting, in the direction of the longitudinal axis, a penetrating recess and being connected, in electrically conductive fashion, in at least one contact point with at least one electrode of the sensor element by means of thick-stranded wire. The invention also relates to a method for producing the Ultrasound Sensor.

Abstract: A fuse apparatus (1) is provided for selectively interrupting a load current (Ia) flowing between a pair of associated conductor leads. The fuse apparatus includes at least two spaced apart electrically conductive contact elements (5) operatively connected with the associated conductor leads. A fuse element (7) is connected to the contact elements (5) using an electrically conductive connection material (9) to allow the current (Ia) to flow between the pair of associated conductor leads. The connection material (9) is adapted to electrically disconnect the fuse element (7) from the contact elements (5) when the current (Ia) exceeds a predetermined current intensity. The connection material (9) has an intrinsic electrical transition resistance characteristic whereby the material develops a temperature in proportion to an intensity of the current. The connection material melts as the current increases to separate the fuse element from the contact elements.

Abstract: A fuse apparatus (1) is provided for selectively interrupting a load current (Ia) flowing between a pair of associated conductor leads. The fuse apparatus includes at least two spaced apart electrically conductive contact elements (5) operatively connected with the associated conductor leads. A fuse element (7) is connected to the contact elements (5) using an electrically conductive connection material (9) to allow the current (Ia) to flow between the pair of associated conductor leads. The connection material (9) is adapted to electrically disconnect the fuse element (7) from the contact elements (5) when the current (Ia) exceeds a predetermined current intensity. The connection material (9) has an intrinsic electrical transition resistance characteristic whereby the material develops a temperature in proportion to an intensity of the current. The connection material melts as the current increases to separate the fuse element from the contact elements.

Abstract: The linear guide system is formed by a tubular body (2) which, internally, has at least three and preferably four guide tracks (33-36, 42, 43) formed, for example, as steel rails (33-36) inserted in an aluminum extrusion which forms the guide body. A slit (7) extends through the outside of the guide body (2); within the guide body, a portion (8) of a carriage is located, which portion includes two bearing elements (11) on either side, formed with two outer tracks (14, 15) for a group of balls (10) to run on the bearing (9) formed by the tracks in the guide body (2) and on the bearing elements (11). To return the balls, upon motion of the carriage, ball return guide elements (24, 25) are located on both ends of the bearing elements (11), and so arranged that they take balls from an upper track (14) and pass them through a duct (16) near the bottom of the bearing element (11).

Abstract: To reliably seal an elongated slit (8) passing through an essentially tubular guide body (6) against contamination by dirt, machine cutting chips and the like, while permitting passage of a movable projecting element through the slit, a cover tape (14) is placed over the slit, but removable therefrom. The cover tape (14) is locked to the guide body (6) by a releasable locking arrangement which includes interengaging, interlocking projection (26) and recess (35) means, located at the sides of the tape (14) on the guide body (6), respectively. The projection means is formed by a headed elongated rib (27), preferably located on the guide body, and the recess means (35) are formed by a groove between a pair of laterally deflectable lips (36, 37), which can snap over the head portion (28) of the rib for positive engagement, while requiring only little force to lift them off the head portion.