Patents by Inventor Uwe Trostmann

Uwe Trostmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-indolyl maleinimide or indolopyrrolo carbazole containing an amino acid as PKC inhibitors
    Patent number: 5750555
    Abstract: The instant invention is a compound of formulaA--X--Y--E.sub.n --R.sup.5in which A is a bis-indolylmaleinimide or indolopyrrolocarbazole useful in the treatment and/or prevention of cancer, viral diseases, thrombosis, heart rhythm disturbances, atherosclerosis, bronchopulmonary diseases, degenerative diseases of the central nervous system, inflammatory diseases, diseases of the immune system, psoriasis, and immune suppression. A pharmaceutical composition and methods of preparing the compounds are also included.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: May 12, 1998
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Uwe Trostmann, Christoph Schachtele, Johannes Hartenstein, Claus Rudolph, Hubert Barth, Reinhard Reck, Walter Kolch
  • 2-aminocarboxylic acids and their derivatives, processes for their preparation and their use as medicaments
    Patent number: 5401875
    Abstract: The invention concerns 2-aminocarboxylic acids and derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing them for the inhibition of protein kinase C and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system.
    Type: Grant
    Filed: April 22, 1991
    Date of Patent: March 28, 1995
    Assignee: Godecke Aktiengesellschaft
    Inventors: Uwe Trostmann, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hartmut Osswald, Gunter Weinheimer
  • Amino acid analogs as CCK antagonists
    Patent number: 5331006
    Abstract: Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. The compounds are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, and opioids. The compounds are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: July 19, 1994
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Julian Aranda, Corinne Augelli-Szafran, Hans-Jurgen Betche, Ann Holmes, Michael D. Mullican, Martyn C. Pritchard, Reginald S. Richardson, Edward Roberts, Bruce D. Roth, Bradley D. Tait, Bharat K. Trivedi, Uwe Trostmann, Paul C. Unangst
  • N-substituted cycloalkyl and polycycloalkyl polyhydro-.beta.-carboline-phenylalanine- and phenethylamine derivatives
    Patent number: 5244905
    Abstract: Novel substituted polyhydro-.beta.-carboline derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotic agents are disclosed. Further the compounds are antianxiety agents and antiulcer agents. Further, the compounds are useful for treating and/or preventing panic attacks. They are agents useful for preventing the response to withdrawal from chronic treatment with or use of nicotine, caffeine, diazepam, alcohol, cocaine or opioids. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: September 14, 1993
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Edward Roberts, Uwe Trostmann
  • 2-acyloxypropylamino derivatives, processes for the preparation thereof, and pharmaceutical compositions containing them
    Patent number: 4855489
    Abstract: The present invention covers a novel series of 2-acyloxypropylamine derivatives, processes for preparing them, compositions containing them, and methods for using them. The compounds are active in the inhibition of protein kinase C and thrombocyto aggregation stimulated by diacylglycerols.
    Type: Grant
    Filed: July 15, 1987
    Date of Patent: August 8, 1989
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Uwe Trostmann, Christoph Schachtele, Karl Mannhardt, Claus Rudolph, Dieter Marme