Abstract: The present invention generally relates to a mixing nozzle (12) for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle (10) is configured to be coupled to a body (11) of a multi-component application device (10), in particular to a body (11) of a two-component syringe assembly, for injection of a liquid composition, which body (11) is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device (10) comprising said mixing nozzle (12) and to a kit comprising said mixing nozzle (12) or said application device (10). Furthermore, the present invention relates to a method using said application device or said kit, for example for replacing or filling a biological tissue or increasing the volume of a biological tissue.

Abstract: The present invention relates to a plunger (20) and a finger grip (30) for a syringe assembly (100), methods for manufacturing them, to a syringe assembly (100), to a kit comprising parts of a syringe assembly (100), and to the use of a syringe assembly (100) or of a kit, wherein the syringe assembly (100) comprises a syringe barrel (10), a finger grip (30) having flanges (31, 32), and a plunger (20) having a plunger rod (21) and a plunger head (22). The plunger (20) comprises a grip pad (23) made by injection molding and attached to a proximal facing surface (24) of the plunger head. The finger grip (20) comprises a grip pad (35) also made by injection molding and attached to a distal facing surface of at least one flange (31, 32) of the finger grip (30).

Abstract: A disposable injector with a piston actuation ram is mounted in a housing, is loaded by a spring energy accumulator and can be unlocked by a displaceable trigger device. The piston actuation ram can be supported by a tensioning rod mounted in the housing. The trigger device comprises a trigger ring displaceable relative to the housing. The tensioning rod can be supported directly or indirectly by a bearing surface of the trigger ring. The bearing surface encloses an angle of between ten degrees and forty five degrees with the longitudinal direction of the disposable injector. The point of the angle lies offset with respect to the trigger ring in the triggering direction of the disposable injector. A disposable injector with increased trigger reliability is developed.

Abstract: The invention relates to an adapter system comprising a frame and a lid that supports an active ingredient pad and serves to close said frame, the active ingredient pad being inserted into the frame in an operating position. The frame and the lid are interconnected force-fittingly and/or form-fittingly when in the operating position. The present invention makes it possible to position the active ingredient pad with precision.

Abstract: The present invention generally relates to a mixing nozzle (12) for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle (10) is configured to be coupled to a body (11) of a multi-component application device (10), in particular to a body (11) of a two-component syringe assembly, for injection of a liquid composition, which body (11) is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device (10) comprising said mixing nozzle (12) and to a kit comprising said mixing nozzle (12) or said application device (10). Furthermore, the present invention relates to a method using said application device or said kit, for example for replacing or filling a biological tissue or increasing the volume of a biological tissue.

Abstract: A disposable injector comprising a housing, a spring-loaded piston-actuating plunger arranged in the housing and able to be released by a trigger unit. A cylinder-piston unit comprising a cylinder and a piston that is positioned at a distance from the piston-actuating plunger. A closed layer made on an elastically-deformable material surrounds the piston-actuating plunger in at least some sections and projects beyond same in the trigger direction, resulting in a disposable injector that will not alarm a patient during use thereof.

Abstract: A device with a positioning frame which can be adhered onto the skin and with a transdermal therapeutic system which can be inserted into a cut-out that passes through the positioning frame. The active substance dispensing outlet side of the inserted transdermal therapeutic system facing the skin. The device includes a tool unit which can be inserted into the cut-out of the positioning frame and centered in said cut-out in order to produce openings at least in the uppermost layer of the skin.

Abstract: A single-use injector having a plunger actuator which is mounted in a housing, which is loaded by a spring energy store, and which can be unlocked by a movable release device. The plunger actuator can be supported by a traction rod mounted in the housing. The movable release device includes a casing housing. The casing housing includes an upper shell and a lower shell, the separation line of which is oriented in the longitudinal direction of the single-use injector. The casing housing has a cornerless cross-section deviating from a circular shape. The housing is anti-rotationally centered in the casing housing.

Abstract: A disposable injector with a piston actuation ram is mounted in a housing, is loaded by a spring energy accumulator and can be unlocked by a displaceable trigger device. The piston actuation ram can be supported by a tensioning rod mounted in the housing. The trigger device comprises a trigger ring displaceable relative to the housing. The tensioning rod can be supported directly or indirectly by a bearing surface of the trigger ring. The bearing surface encloses an angle of between ten degrees and forty five degrees with the longitudinal direction of the disposable injector. The point of the angle lies offset with respect to the trigger ring in the triggering direction of the disposable injector. A disposable injector with increased trigger reliability is developed.

Abstract: A disposable injector comprising a housing, a spring-loaded piston-actuating plunger arranged in the housing and able to be released by a trigger unit. A cylinder-piston unit comprising a cylinder and a piston that is positioned at a distance from the piston-actuating plunger. A closed layer made on an elastically-deformable material surrounds the piston-actuating plunger in at least some sections and projects beyond same in the trigger direction, resulting in a disposable injector that will not alarm a patient during use thereof.

Abstract: The invention relates to the needle-free subcutaneous administration of proteins to humans and animals by means of a protein delivery device comprising a unit made of a nozzle, a chamber, a piston, an actuating device, and a drive, and a corresponding process and its use.

Abstract: A device with a positioning frame which can be adhered onto the skin and with a transdermal therapeutic system which can be inserted into a cut-out that passes through the positioning frame. The active substance dispensing outlet side of the inserted transdermal therapeutic system facing the skin. The device includes a tool unit which can be inserted into the cut-out of the positioning frame and centered in said cut-out in order to produce openings at least in the uppermost layer of the skin.

Abstract: A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.

Abstract: Embodiments of the invention relate to a transfer device for a container whose interior is under negative pressure and which is closed by means of an elastic stopper. The device has a receiving cap and a piercing mandril for piercing the stopper. Relative to its direction of piercing, the piercing mandril is provided with a front piercing portion and with a rear sealing portion which is of greater diameter. In the position in which a bead of the container is inserted into the receiving cap, the sealing portion contacts the stopper. In this way, a tear in the stopper, which tear has been formed by eccentric application of the device onto the container, can be sealed off.

Abstract: A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.

Abstract: Embodiments of the invention include a fluid transfer device, for example, for medical fluids. The device includes a housing, two piercing elements mounted in the housing, and a slide arranged between the piercing elements. The slide may be displaced with respect to the piercing elements such that, in a first position, a flow connection is established between the two piercing elements, and, in a second position, a flow connection is established between one of the piercing elements and a lateral opening of the housing. In the area of the lateral opening, the housing may have a connector for insertion of a syringe cone of a syringe. When the syringe cone is inserted into the connector, the front end of the syringe cone may move the slide from the first position to the second position.

Abstract: The invention relates to a cylinder/piston unit having a cylinder and a piston which is guided therein, wherein the cylinder and the piston enclose a chamber which can be filled at least for a time with an additive, and the cylinder has at least one exit element at its front end. Here, the cross section of the chamber or the cross section of the cylinder inner wall is increased at least in regions of the cylinder from the front to the back, wherein the cylinder end having the exit element is at the front. The piston has an elastic skirt at least in the front region, the front outer edge of said elastic skirt defining a cross-sectional area in the case of an unloaded piston, which is greater than an area which is defined by a contour line. The present invention develops a cylinder/piston unit which ensures simple and reliable handling and can be stored for a long time in the filled state, in a manner which is impervious to gas and moisture.