Patents by Inventor Uyanga Tsedev

Uyanga Tsedev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimization of circular single stranded DNA using M13 phage
    Patent number: 11976270
    Abstract: Provided herein, in some aspects, are methods and compositions for producing single-stranded DNA (ssDNA) having uniform length.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: May 7, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Angela Belcher, Christopher A. Voigt, Uyanga Tsedev, Tae-Gon Cha
  • Homogeneous engineered phage populations
    Patent number: 11896633
    Abstract: Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin-phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: February 13, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Angela M. Belcher, Uyanga Tsedev, Fred Lam
  • M13 PHAGE BASED GENE THERAPY PLATFORM
    Publication number: 20230041208
    Abstract: An engineered phage-derived particle (PDP) for expressing a transgene in a target cell transduced with a bacteriophage, the PDP includes (i) less than about 500 bp of DNA from the bacteriophage genome, (ii) an ITR-flanked therapeutic gene up to 20 kb, (iii) an endosomal escape sequence, (iv) a nuclear localization sequence, and (v) a cell-specific targeting moiety. The PDP may escape lysosomal degradation, traffic across the nuclear envelope and expressed a therapeutic gene in a mammalian cell.
    Type: Application
    Filed: May 6, 2022
    Publication date: February 9, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Uyanga Tsedev, Angela M. Belcher
  • HOMOGENEOUS ENGINEERED PHAGE POPULATIONS
    Publication number: 20210205381
    Abstract: Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin-phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.
    Type: Application
    Filed: March 22, 2021
    Publication date: July 8, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Angela M. Belcher, Uyanga Tsedev, Fred Lam
  • Homogeneous engineered phage populations
    Patent number: 10987388
    Abstract: Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin-phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: April 27, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Angela M. Belcher, Uyanga Tsedev, Fred Lam
  • OPTIMIZATION OF CIRCULAR SINGLE STRANDED DNA USING M13 PHAGE
    Publication number: 20200362332
    Abstract: Provided herein, in some aspects, are methods and compositions for producing single-stranded DNA (ssDNA) having uniform length.
    Type: Application
    Filed: May 14, 2020
    Publication date: November 19, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Angela Belcher, Christopher A. Voigt, Uyanga Tsedev, Tae-Gon Cha
  • PREFABRICATED ALGINATE-DRUG BANDAGES
    Publication number: 20190343979
    Abstract: The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
    Type: Application
    Filed: July 9, 2019
    Publication date: November 14, 2019
    Inventors: Cathal J. Kearney, Uyanga Tsedev, David J. Mooney, Aristidis Veves, Thomas Michael Braschler, Sidi A. Bencherif
  • Prefabricated alginate-drug bandages
    Patent number: 10391196
    Abstract: The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: August 27, 2019
    Assignees: President and Fellows of Harvard College, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Cathal J. Kearney, Uyanga Tsedev, David J. Mooney, Aristidis Veves, Thomas Michael Braschler, Sidi A. Bencherif
  • ENGINEERED BACTERIOPHAGE SYSTEMS
    Publication number: 20190022155
    Abstract: Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin -phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.
    Type: Application
    Filed: July 20, 2018
    Publication date: January 24, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Angela M. Belcher, Uyanga Tsedev, Fred Lam
  • PREFABRICATED ALGINATE-DRUG BANDAGES
    Publication number: 20180333513
    Abstract: The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
    Type: Application
    Filed: June 8, 2018
    Publication date: November 22, 2018
    Inventors: Cathal J. Kearney, Uyanga Tsedev, David J. Mooney, Aristidis Veves, Thomas Michael Braschler, Sidi A. Bencherif
  • Prefabricated alginate-drug bandages
    Patent number: 10016524
    Abstract: The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: July 10, 2018
    Assignees: President and Fellows of Harvard College, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Cathal J. Kearney, Uyanga Tsedev, David J. Mooney, Aristidis Veves, Thomas Michael Braschler, Sidi A. Bencherif
  • PREFABRICATED ALGINATE-DRUG BANDAGES
    Publication number: 20160058903
    Abstract: The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 3, 2016
    Inventors: Cathal J. Kearney, Uyanga Tsedev, David J. Mooney, Aristidis Veves, Thomas Michael Braschler, Sidi A. Bencherif