Abstract: Provided herein are methods of treating cancer or infection, which comprise administering to a human patient in need thereof: (a) an anti-human PD-1 monoclonal antibody or antigen binding fragment thereof; (b) an anti-human LAG3 monoclonal antibody or antigen binding fragment thereof; and (c) an anti-human TIGIT monoclonal antibody or antigen binding fragment thereof. Also provided are pharmaceutical compositions and kits containing such agents for the treatment of cancer or infection.

Abstract: A method can comprise: generating, via a processor, a digital representation of a portion of a repaired bladed rotor, the digital representation based on a geometrical dimensions determined from an inspection of an inspected bladed rotor and a repair blend profile for a defect of the inspected bladed rotor; performing, via the processor, a structural simulation on a structural model, the structural model based on the digital representation of the repaired bladed rotor; performing, via the processor, an aerodynamic simulation on an aerodynamic model, the aerodynamic model based on the digital representation of the repaired bladed rotor; and determining, via the processor, whether results from the structural simulation and the aerodynamic simulation meet an experience based criteria for the repaired bladed rotor.

Abstract: A method can comprise: receiving an inspection data corresponding to a geometry of an inspected bladed rotor; performing a baseline evaluation based on the inspection data; determining a plurality of candidate repair profiles for a defect of the inspected bladed rotor; performing an updated evaluation for each candidate repair profile in the plurality of candidate repair profiles; selecting a selected candidate repair profile in the plurality of candidate repair profiles based on the updated evaluation for each candidate repair profile in the plurality of candidate repair profiles; and performing a repair based on the selected candidate repair profile.

Abstract: A method can comprise: receiving, via a processor, scanner data from an inspection system for a bladed rotor, the scanner data including a point cloud defining an inspected bladed rotor, the scanner data including a first data size; generating, via the processor, a data set including section files spaced apart along a span of a blade based on the point cloud; determining, via the processor, a defect on the blade of the inspected bladed rotor based on the data set; and determining whether the defect meets serviceable limits.

Abstract: A method of projecting effects of blade modes onto rotor modes can comprise receiving, via a processor, a modal domain for an ideal bladed rotor and each blade of an inspected bladed rotor; determining, via the processor, whether a mode in the modal domain is at least one of an isolated mode and within a cluster of modes; analyzing, via the processor, the mode individually in response to the mode being isolated; and analyze, via the processor, the cluster of modes together in response to the mode being within the cluster of modes.

Abstract: A method can comprise: determining, via a processor, whether serviceable limits are met for an inspected bladed rotor; generating, via the processor, a three-dimensional model including a repair blend profile for a defect in response to determining the inspected bladed rotor does not meet the serviceable limits; performing, via the processor, a first set of simulations on the three-dimensional model; determining, via the processor, whether a first set of results of the first set of simulations meet an experience based criteria; performing, via the processor, a second set of simulations on the three-dimensional model in response to a first result in the first set of results not meeting a first objective parameter in the experience based criteria; and determining, via the processor, whether a second set of results and the first set of results meet a deterministic criteria.

Abstract: A method can comprise: performing a finite element static analysis of an inspected blade of an inspected bladed rotor, the inspected blade having a repair blend profile modeled thereon, the repair blend profile exceeding a threshold repair size; performing a finite element modal analysis of the inspected blade having the repair blend profile; performing a fatigue assessment based on results from the finite element static analysis and the finite element modal analysis, the fatigue assessment including limits based on material properties of the inspected blade, the material properties based on test results at a threshold significance level; and repairing the inspected bladed rotor with the repair blend profile in response to the fatigue assessment meeting a deterministic criteria.

Abstract: A method is providing comprising receiving, via a processor, a digital representation of a potentially repaired blade from an inspection system, the digital representation including a repair blend profile, the digital representation based on an inspected blade of an inspected bladed rotor; generating, via the processor, an airfoil definition file corresponding to the digital representation, inputting, via the processor, the airfoil definition file into an aerodynamic simulator, receiving, via the processor, simulation results from the aerodynamic simulator of the potentially repaired blade; analyzing, via the processor, an overall engine impact of the potentially repaired blade based on the simulation results, inputting, via the processor, a plurality of simulation results into an aerodynamic effect translator, and receiving, via the processor, a translated impact for local effect of a repaired bladed rotor with the potentially repaired blade.

Abstract: Provided herein are methods of treating cancer or infection, which comprise administering to a human patient in need thereof: (a) an anti-human PD-1 monoclonal antibody or antigen binding fragment thereof; (b) an anti-human LAG3 monoclonal antibody or antigen binding fragment thereof; and (c) an anti-human TIGIT monoclonal antibody or antigen binding fragment thereof. Also provided are pharmaceutical compositions and kits containing such agents for the treatment of cancer or infection.

Abstract: Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 (“PD-1”) or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.

Abstract: A knife edge seal includes a pedestal and a knife edge with a tip and a base. The base rests on the pedestal. The base has a first width and the tip has a second width, and the ratio of the first width to the second width is in the range of 5:1 to 15:1. A gas turbine engine and a method of sealing a high pressure area from a low pressure area are also disclosed.

Abstract: A knife edge seal includes a pedestal and a knife edge with a tip and a base. The base rests on the pedestal. The base has a first width and the tip has a second width, and the ratio of the first width to the second width is in the range of 5:1 to 15:1. A gas turbine engine and a method of sealing a high pressure area from a low pressure area are also disclosed.

Abstract: A system for assembling a turbine engine component has a disk having a groove, which groove has a bearing surface and an upper wall, at least one locking slot being positioned at an intersection of the bearing surface and the upper wall; each locking slot having a shaped surface; and at least one lock having a shape which matches and mates with the shaped surface of the locking slot; and said locking slots providing clearance to assemble blades into the disk.

Abstract: A compressor rotor has a rotor centered on an axis, and a groove with opposed side edges. The groove receives a plurality of removable compressor blades, and has tangential sides. The tangential side surfaces are in contact with said tangential sides of the groove, and at least one slot is cut into the side edges. A first radial distance is measured from a radially outer edge of the side edge to a radially outer beginning point of the tangential sides of the groove. A second radial distance is radially between the radially outer beginning point of the tangential sides to a radially inner end of the tangential sides of the groove. A ratio of the first and second radial distance is between 1.1 and 5.0.

Abstract: A system for assembling a turbine engine component has a disk having a groove, which groove has a bearing surface and an upper wall, at least one locking slot being positioned at an intersection of the bearing surface and the upper wall; each locking slot having a shaped surface; and at least one lock having a shape which matches and mates with the shaped surface of the locking slot; and said locking slots providing clearance to assemble blades into the disk.