Patents by Inventor V. G. Matassa

V. G. Matassa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine derivatives as 5-HT.sub.1 Agonists
    Patent number: 5614524
    Abstract: A class of substituted piperazine derivatives of formula I ##STR1## are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated conditions, for which a selective agonist of these receptors is indicated.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: March 25, 1997
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: V. G. Matassa, L. J. Street, A. J. Reeve
  • Five-membered heteroaromatic compounds as 5-HT receptor agonists
    Patent number: 5552402
    Abstract: A class of substituted five-membered heteroaromatic compounds are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: September 3, 1996
    Assignee: Merck, Sharp & Dohme Ltd.
    Inventors: V. G. Matassa, L. J. Street, G. A. Showell
  • Benzodiazepine derivatives
    Patent number: 5302591
    Abstract: Compounds of formula (I), and salts and prodrugs thereof ##STR1## R.sup.1 is H, certain optionally substituted alkyl or C.sub.3-7 cycloalkyl;R.sup.2 represents (CH.sub.2).sub.m -tetrazolyl, (CH.sub.2).sub.m -imidazolyl, CONR.sup.6 R.sup.7, CONHSO.sub.2 R.sup.9, SO.sub.2 NHCOR.sup.9, SOC.sub.1-4 alkyl, SO.sub.2 NHR.sup.10, 5-hydroxy-4-pyrone, (CH.sub.2).sub.n CO.sub.2 H, ##STR2## or a group ##STR3## wherein X is O, S or NR.sup.11 ; one of Z and Y is C.dbd.O and the other is O, S or NR.sup.12 ;R.sup.3 represents H or C.sub.1-6 alkyl;R.sup.4 represents 2-, 3- or 4-pyridyl;R.sup.5 represents C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; andx is 0, 1, 2 or 3;are CCK and/or gastrin receptor antagonists useful in therapy.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: April 12, 1994
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: S. R. Fletcher, V. G. Matassa