Abstract: A process for bioprinting wherein a matrix comprising a modified primary hydroxyl groups containing polysaccharide comprising repeating disaccharide units wherein in at least part of the disaccharide units the primary hydroxyl group is replaced by functional groups selected from carboxyl groups, halide groups or groups comprising sulfur or phosphorus atoms, like e.g. sulfate groups, sulfonate groups, phosphonate groups and phosphate groups, is used and bioink formulations.

Abstract: Injectable hydrogels comprising polysaccharides based on disaccharides the backbones of which form an ?-helix structure and in which in at least 10% of the disaccharide units the primary hydroxyl groups are oxidized.

Abstract: The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture.

Abstract: In one aspect, the invention relates to functionalized solid lipid nanoparticles comprising a neutral lipid and a first functionalized polymer comprising at least one ionic or ionizable moiety and methods for providing same. In a further aspect, the invention relates to tumor targeting therapeutic systems, multimodal diagnostic therapeutic systems, thermoresponsive payload delivery systems, magnetic-driven targeting systems, therapeutic diagnostic systems, stabilized ink compositions, and cosmetic formulations comprising the solid lipid nanoparticles of the invention. In a further aspect, the invention relates to methods of delivering at least one biologically active agent, pharmaceutically active agent, magnetically active agent, or imaging agent across the blood-brain barrier, across a cellular lipid bilayer and into a cell, and to a subcellualr structure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: In one aspect, the invention relates to a synthetic conduit comprising a substantially tubular body comprising substantially circumferential polymer fibers; wherein the body has an exterior surface, an interior surface, and a lumen extending therethrough; and wherein the body has microscale features disposed at the interior surface. In a further aspect, cells can be optionally adhered to the exterior and/or interior surface of the substantially tubular body. In various aspects, the conduit can be used as a vascular prosthesis, a stent, or a nerve regeneration scaffold. Methods of preparing and implanting same are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention relates to novel initiator systems, methods of use, and cured composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to a crosslinkable prepolymer where crosslinking is initiated by a two part system and a composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture and a delivery system for cross-linking the polymer.