Patents by Inventor Vaclav NAVRATIL

Vaclav NAVRATIL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SAMPLE COLLECTION DEVICE
    Publication number: 20240081790
    Abstract: A sample collection device is provided and includes a hollow upper portion, a tubular lower portion, and at least one groove. The hollow upper portion tapers between a first open end and a second open end. The upper portion also defines a sample collection volume. The tubular lower portion extends along a longitudinal axis from the second open end to an open terminal end of the device. The lower portion further defines a lumen in fluid communication with the sample collection volume and the open terminal end. The at least one groove protrudes inward from an outer surface of the lower portion and extends along at least a portion of a length of the lower portion.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 14, 2024
    Inventor: Václav NAVRÁTIL
  • DETECTION OF NUCLEIC ACIDS USING DIRECT RT-PCR FROM BIOLOGICAL SAMPLES
    Publication number: 20240026438
    Abstract: The present disclosure generally relates to systems, compositions, kits, and methods for detection of nucleic acids in biological samples. The present disclosure also relates to ultrasensitive direct detection of pathogenic nucleic acids in various biological samples without the need to isolate the nucleic acids from the samples. The present disclosure further relates to detection of airborne or blood borne viruses directly from biological samples.
    Type: Application
    Filed: December 9, 2021
    Publication date: January 25, 2024
    Inventor: Václav NAVRÁTIL
  • Method of detection of analyte active forms and determination of the ability of substances to bind into analyte active sites
    Patent number: 10718772
    Abstract: A method for detection of active form of analytes in a sample and/or for determination of ability of tested substances to bind to the active site of these analytes has the following steps: a) analyte or group of analytes from the sample is immobilized on the surface of a solid carrier; b) analyte or group of analytes is incubated with a detection probe; c) then the solid carrier is washed to remove unbound detection probe; and subsequently, the amount of bound detection probe is determined.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: July 21, 2020
    Assignee: USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, V.V.I.
    Inventors: Vaclav Navratil, Pavel Sacha, Jiri Schimer, Jan Konvalinka, Pavel Majer
  • Macromolecular conjugates for visualization and separation of proteins and cells
    Patent number: 10302632
    Abstract: A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: May 28, 2019
    Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA
    Inventors: Pavel Sacha, Jan Konvalinka, Jiri Schimer, Tomas Knedlik, Vaclav Navratil, Jan Tykvart, Frantisek Sedlak, Pavel Majer, Petr Cigler, Vladimir Subr, Karel Ulbrich, Jiri Strohalm
  • MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS
    Publication number: 20190033300
    Abstract: A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.
    Type: Application
    Filed: September 12, 2018
    Publication date: January 31, 2019
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA
    Inventors: PAVEL SACHA, JAN KONVALINKA, JIRI SCHIMER, TOMAS KNEDLIK, VACLAV NAVRATIL, JAN TYKVART, FRANTISEK SEDLAK, PAVEL MAJER, PETR CIGLER, VLADIMIR SUBR, KAREL ULBRICH, JIRI STROHALM
  • MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS
    Publication number: 20180052152
    Abstract: Macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe, and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells. The targeting ligand may be attached to the synthetic copolymer via a flexible linker.
    Type: Application
    Filed: January 13, 2016
    Publication date: February 22, 2018
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA
    Inventors: Pavel Sacha, Jan KONVALINKA, Jiri SCHIMER, Tomas KNEDLIK, Vaclav NAVRATIL, Jan TYKVART, Frantisek SEDLAK, Pavel MAJER, Petr CIGLER, Vladimir SUBR, Karel ULBRICH, Jiri STROHALM
  • METHOD OF DETECTION OF ANALYTE ACTIVE FORMS AND DETERMINATION OF THE ABILITY OF SUBSTANCES TO BIND INTO ANALYTE ACTIVE SITES
    Publication number: 20170219583
    Abstract: A method for detection of active form of analytes in a sample and/or for determination of ability of tested substances to bind to the active site of these analytes has the following steps: a) analyte or group of analytes from the sample is immobilized on the surface of a solid carrier; b) analyte or group of analytes is incubated with a detection probe; c) then the solid carrier is washed to remove unbound detection probe; and subsequently, the amount of bound detection probe is determined.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 3, 2017
    Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, V.V.I.
    Inventors: Vaclav NAVRATIL, Pavel SACHA, Jiri SCHIMER, Jan KONVALINKA, Pavel MAJER