Patents by Inventor Vadim Cherezov

Vadim Cherezov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL FUSION PARTNERS FOR THE PURPOSE OF CRYSTALLIZING G-PROTEIN COUPLED RECEPTORS
    Publication number: 20170218047
    Abstract: GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (C-term-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described.
    Type: Application
    Filed: November 9, 2016
    Publication date: August 3, 2017
    Inventors: Michael A. Hanson, Christopher B. Roth, Raymond C. Stevens, Joshua M. Kunken, Mark T. Griffith, Aaron A. Thompson, Wei Liu, Fei Xu, Vsevolod Katritch, Vadim Cherezov
  • Human Aadenosine receptor crystals and uses thereof
    Patent number: 8536306
    Abstract: The invention provides the structure of human A2A adenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: September 17, 2013
    Assignee: The Scripps Research Institute
    Inventors: Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov, Mark Griffith, Veli-Pekka Jaakola
  • Methods and compositions for obtaining high-resolution crystals of membrane proteins
    Patent number: 8252899
    Abstract: The invention describes compositions and method useful for the crystallization of membrane proteins.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: August 28, 2012
    Assignee: The Scripps Research Institute
    Inventors: Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov, Peter Kuhn
  • HUMAN A2A ADENOSINE RECEPTOR CRYSTALS AND USES THEREOF
    Publication number: 20120123092
    Abstract: The invention provides the structure of human A2A adenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.
    Type: Application
    Filed: October 1, 2009
    Publication date: May 17, 2012
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov, Mark Griffith, Veli-Pekka Jaakola
  • Crystals of membrane proteins
    Publication number: 20120100593
    Abstract: A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme.
    Type: Application
    Filed: September 2, 2011
    Publication date: April 26, 2012
    Applicant: The Scripps Research Institute
    Inventors: Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov, Peter Kuhn
  • CHOLESTEROL CONSENSUS MOTIF OF MEMBRANE PROTEINS
    Publication number: 20110130543
    Abstract: The invention provides the structure of a human ?2-adrenergic receptor, a cholesterol consensus motif, and methods of identifying modulators of G-protein coupled receptors (GPCRs). Methods of using the modulators of the receptor, GPCRs, and the cholesterol consensus motif are also provided.
    Type: Application
    Filed: October 22, 2008
    Publication date: June 2, 2011
    Inventors: Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov
  • METHODS AND COMPOSITIONS FOR OBTAINING HIGH-RESOLUTION CRYSTALS OF MEMBRANE PROTEINS
    Publication number: 20110031438
    Abstract: The invention describes compositions and method useful for the crystallization of membrane proteins.
    Type: Application
    Filed: October 22, 2008
    Publication date: February 10, 2011
    Inventors: Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov, Peter Kuhn