Abstract: A system, method and software application for neuropsychological evaluation screening, the system comprising: an application server controlling a software application installed in a communication device, the server comprising at least one processor configured to execute code instructions for: generating a classifier engine based on communication data and diagnosis of diagnosed subjects by input feature signals of the communication data to a plurality of classifiers, calculate predictive accuracy for each classifier, and generate a combination of classifiers based on the predictive accuracy; collecting text and vocal data from multiple communication channels at the communication device; input feature signals of the collected data to the plurality of classifiers; and execute the combination of classifiers.