Patents by Inventor Vadim Kraynov

Vadim Kraynov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acid Linked Dolastatin Derivatives
    Publication number: 20150080559
    Abstract: Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: May 24, 2012
    Publication date: March 19, 2015
    Applicant: AMBRX, INC.
    Inventors: Zhenwei Miao, Kyle Atkinson, Sandra Biroc, Timothy Buss, Melissa Neal, Vadim Kraynov, Robin Mardsen, Jason Pinkstaff, Lillian Skidmore, Ying Sun, Agnieszka Szydlik, Ianina Valenta
  • Modified insulin polypeptides and their uses
    Patent number: 8946148
    Abstract: Modified insulin polypeptides and their uses thereof are provided.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: February 3, 2015
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Denise Krawitz, Vadim Kraynov, Feng Tian, Bee-Cheng Sim, Lillian Skidmore, Anna-Maria A. Hays Putnam, Nick Knudsen, Michael Deguzman
  • Modified Adiponectin Polypeptides and Their Uses
    Publication number: 20150031864
    Abstract: Modified adiponectin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 27, 2013
    Publication date: January 29, 2015
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Putnam
  • Modified Relaxin Polypeptides and Their Uses
    Publication number: 20140194357
    Abstract: Modified relaxin polypeptides and their uses thereof are provided
    Type: Application
    Filed: January 10, 2014
    Publication date: July 10, 2014
    Applicant: AMBRX, INC.
    Inventors: VADIM KRAYNOV, NICK KNUDSEN, AHMA HEWET, KRISTINE DE DIOS, JASON PINKSTAFF, LORRAINE SULLIVAN
  • Relaxin polypeptides comprising non-naturally encoded amino acids
    Patent number: 8735539
    Abstract: Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: May 27, 2014
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Ahma Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
  • Relaxin polypeptides comprising non-naturally encoded amino acids
    Patent number: 8691940
    Abstract: Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: April 8, 2014
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Ahma Hewet, Kristine De Dios, Jason Pinkstaff, Lorraine Sullivan
  • MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES
    Publication number: 20130237481
    Abstract: Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.
    Type: Application
    Filed: February 22, 2013
    Publication date: September 12, 2013
    Inventors: Vadim Kraynov, Nick Knudsen, Amha Hewet, Kristine de Dios, Jason Pinkstaff, Lorraine Sullivan
  • Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives
    Patent number: 8383365
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: February 26, 2013
    Assignee: AMBRX, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore (Nee Ho), Jason Pinkstaff, Vadim Kraynov
  • Modified interferon beta polypeptides and their uses
    Patent number: 8329869
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: December 11, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • MODIFIED PORCINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120283172
    Abstract: Modified porcine somatotropin polypeptides and uses thereof are provided.
    Type: Application
    Filed: December 21, 2010
    Publication date: November 8, 2012
    Applicant: AMBRX, INC.
    Inventors: John W. Wallen, III, Nick Knudsen, Vadim Kraynov
  • MODIFIED INTERFERON BETA POLYPEPTIDES AND THEIR USES
    Publication number: 20120197006
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Application
    Filed: January 6, 2012
    Publication date: August 2, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Anna-Maria A. HAYS PUTNAM, Denise KRAWITZ, Jason PINKSTAFF, Heather MYLER
  • Modified Leptin Polypeptides and Their Uses
    Publication number: 20120149636
    Abstract: Modified human leptin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 14, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Hays Putnam, Nick Knudsen, Jason Pinkstaff, Heather Myler, Lorraine Sullivan
  • MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120046229
    Abstract: Modified relaxin polypeptides and their uses thereof are provided
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Amha HEWET, Kristine DE DIOS, Jason PINKSTAFF, Lorraine SULLIVAN
  • Modified interferon beta polypeptides and their uses
    Patent number: 8114630
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: February 14, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • Pegylated human interferon polypeptides
    Patent number: 8093356
    Abstract: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: January 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Anna-Maria A. Hays, Bruce E. Kimmel, Ho Sung Cho, Bee-Cheng Sim, David C. Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas O. Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow
  • Modified FGF-21 polypeptides and their uses
    Patent number: 8012931
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: September 6, 2011
    Assignee: Ambrx, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
  • Modified Human Apolipoprotein A-1 and Their Uses
    Publication number: 20110178029
    Abstract: Modified human apolipoprotein A-I polypeptides and uses thereof are provided.
    Type: Application
    Filed: September 15, 2008
    Publication date: July 21, 2011
    Applicant: AMBRX, INC.
    Inventors: Nick Knudsen, Stuart Bussell, Vadim Kraynov
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20110172401
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian Ho, Jason PINKSTAFF, Vadim KRAYNOV
  • Modified Insulin Polypeptides and Their Uses
    Publication number: 20100298212
    Abstract: Modified insulin polypeptides and their uses thereof are provided
    Type: Application
    Filed: November 20, 2008
    Publication date: November 25, 2010
    Applicant: AMBRX, INC.
    Inventors: Zhenwei Miao, Denise Krawitz, Vadim Kraynov, Tian Feng, Bee-Cheng Sim, Lillian Skidmore, Anna-Maria A. Hays Putnam, Nick Knudesen, Michael Deguzman
  • Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
    Patent number: 7745377
    Abstract: The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site. Biosensors are provided having environmentally sensitive dyes that can locate specific biomolecules within living cells and detect chemical and physiological changes in those biomolecules as the living cell is moving, metabolizing and reacting to its environment. Methods are included for detecting GTP activation of a Rho GTPase protein using polypeptide biosensors. When the biosensor binds GTP-activated Rho GTPase protein, the environmentally sensitive dye emits a signal of a different lifetime, intensity or wavelength than when not bound.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: June 29, 2010
    Assignee: The Scripps Research Institute
    Inventors: Klaus M. Hahn, Alexei Toutchkine, Rajeev Muthyala, Vadim Kraynov, Steven J. Bark, Dennis R. Burton, Chester Chamberlain