Abstract: The invention relates to a novel highly selective and potent NPP1 inhibitors, compositions comprising such, and their use as pharmaceuticals.

Abstract: An apparatus for mixing a fluid material and a solid material comprises (a) a barrel; (b) a plunger displaceable within the barrel; (c) a slider disposed within the barrel between the fluid and solid materials. The slider, when reciprocatively displaced within the barrel, is permeable by the fluid material and the solved solid material under a pressure differential between the fluid and solid materials. The pressure differential is multiply exerted to the slider by the plunger such that a homogeneous mixture is obtained.

Abstract: An automatic apparatus for dispensing a predefined dosage form, comprising a housing and a pressable means coupled to said housing for activating said apparatus, said housing comprising: a chamber for accommodating a gel based carrier, an inlet for receiving a pharmaceutical composition, a mixing means interconnected with said chamber, motor means for operating said mixing means; and an outlet for dispensing said predefined dosage form. The pharmaceutical composition admixed with said gel based carrier by said mixing means forming and administrating a homogeneous mixture of a predefined dosage form by a single press action on said pressable means.

Abstract: The present invention provides composition, apparatus, kit and method for compounding an orally administered dosage form of at least one medicament comprising a container for mixing a crushed medicament with a gel-based carrier. The container comprises at least one chamber and at least one membrane as a separating element. The container comprises a flexible membrane, when removed or partially broken, provides a mixture of a defined dosage form of said medicament comprising the crushed medicament and said gel-based carrier. The membrane is further configured to prevent contamination, overdosing and non sanctioned abuse of active ingredient of said medicament.

Abstract: The present invention provides composition, apparatus, kit and method for compounding an orally administered dosage form of at least one medicament comprising a container for mixing a crushed medicament with a gel-based carrier. The container comprises at least one chamber and at least one membrane as a separating element. The container comprises a flexible membrane, when removed or partially broken, provides a mixture of a defined dosage form of said medicament comprising the crushed medicament and said gel-based carrier. The membrane is further configured to prevent contamination, overdosing and non sanctioned abuse of active ingredient of said medicament.