Patents by Inventor Vadims Dvornikovs

Vadims Dvornikovs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing inhibitors of influenza viruses replication
    Patent number: 11345700
    Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: May 31, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
  • METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
    Publication number: 20200207765
    Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Inventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
  • Methods of preparing inhibitors of influenza viruses replication
    Patent number: 10640501
    Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: May 5, 2020
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
  • METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
    Publication number: 20180282330
    Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 6, 2018
    Publication date: October 4, 2018
    Inventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
  • Methods of preparing inhibitors of influenza viruses replication
    Patent number: 10023569
    Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: July 17, 2018
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
  • METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
    Publication number: 20160251354
    Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 10, 2016
    Publication date: September 1, 2016
    Inventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
  • Structural, behavioral characterization, and synthesis of attractants for migratory lamprey
    Patent number: 7557097
    Abstract: Compounds that function as lamprey attractants and methods.
    Type: Grant
    Filed: November 20, 2004
    Date of Patent: July 7, 2009
    Assignee: Regents of the University of Minnesota
    Inventors: Peter W. Sorensen, Thomas R. Hoye, Jared M. Fine, Vadims Dvornikovs, Jizhou Wang, Lance A. Vrieze
  • Structural, behavioral characterization, and synthesis of attractants for migratory lamprey
    Publication number: 20060111333
    Abstract: Compounds that function as lamprey attractants and methods.
    Type: Application
    Filed: November 20, 2004
    Publication date: May 25, 2006
    Inventors: Peter Sorensen, Thomas Hoye, Jared Fine, Vadims Dvornikovs, Jizhou Wang, Lance Vrieze