Patents by Inventor Vahid Asnafi
Vahid Asnafi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220348660Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive proliferation of mature activated CD4+ T cells associated with the human T-cell lymphotropic virus type I (HTLV-I). The inventors performed an integrated genomic analysis of a retrospective cohort of 62 ATL patients mainly originating from Africa and the Caribbean area. In particular, they identified a subset of mutations in the TCR/NF-KB pathway (PLCG1, CARD11, PRKCB, CBLB, IRF4, CSNK1A1, FYN, RHOA, VAV1). Furthermore, the inventors investigated the effects of an anti-CD3 antibody (OKT3) exposure on 4 ATL samples including 2 cases harboring CARD 11 and PRKCB gain of function alterations and 2 cases without any TCR pathway mutation. The data suggest that ATL harboring TCR pathway mutations clearly responded to anti-CD3 (FIG. 1B, red+OKT3) and died by apoptosis possibly by a mechanism resembling AICD. Importantly, these TCR-pathway/NFKB mutated patients also showed poorer outcome as compared to unmutated cases.Type: ApplicationFiled: October 1, 2020Publication date: November 3, 2022Inventors: Vahid ASNAFI, Olivier HERMINE, Ambroise MARÇAIS, Jacques GHYSDAEL
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Publication number: 20210263017Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: March 8, 2021Publication date: August 26, 2021Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martín Ayuso, Carlos Eduardo Pedreira
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Patent number: 10942172Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: December 20, 2017Date of Patent: March 9, 2021Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstrikova, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martin Ayuso, Carlos Eduardo Pedreira
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Patent number: 10942171Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: December 20, 2017Date of Patent: March 9, 2021Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstrikova, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martín Ayuso, Carlos Eduardo Pedreira
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Patent number: 10209245Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: December 20, 2017Date of Patent: February 19, 2019Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstrikova, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martín Ayuso, Carlos Eduardo Pedreira
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Publication number: 20180180597Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: December 20, 2017Publication date: June 28, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marin Ayuso, Carlos Eduardo Pedreira
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Publication number: 20180180598Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: December 20, 2017Publication date: June 28, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marin Ayuso, Carlos Eduardo Pedreira
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Publication number: 20180120301Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: December 20, 2017Publication date: May 3, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marin Ayuso, Carlos Eduardo Pedreira
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Patent number: 9880158Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least three identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: June 2, 2010Date of Patent: January 30, 2018Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria Van Dongen, José Alberto Orfao De Matos Correia E Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van Der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary De Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marín Ayuso, Carlos Eduardo Pedreira
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Publication number: 20120165213Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least three identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: June 2, 2010Publication date: June 28, 2012Applicant: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAMInventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marín Ayuso, Carlos Eduardo Pedreira