Patents by Inventor Vaibhav A. PANDIT

Vaibhav A. PANDIT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOPARTICLE-MEDIATED GENE DELIVERY, GENOMIC EDITING AND LIGAND-TARGETED MODIFICATION IN VARIOUS CELL POPULATIONS
    Publication number: 20200181642
    Abstract: An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide. Also provided is an improved method of modifying intracellular polynucleotides. The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 11, 2020
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Shiva Prasad KOTHA, Andre Ronald WATSON, Vaibhav A. PANDIT
  • Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations
    Patent number: 10526616
    Abstract: An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide. Also provided is an improved method of modifying intracellular polynucleotides. The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: January 7, 2020
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Shiva Prasad Kotha, Andre Ronald Watson, Vaibhav A. Pandit
  • NANOPARTICLE-MEDIATED GENE DELIVERY, GENOMIC EDITING AND LIGAND-TARGETED MODIFICATION IN VARIOUS CELL POPULATIONS
    Publication number: 20160230189
    Abstract: An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating , where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide. Also provided is an improved method of modifying intracellular polynucleotides. The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
    Type: Application
    Filed: September 23, 2014
    Publication date: August 11, 2016
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Shiva Prasad KOTHA, Andre Ronald WATSON, Vaibhav A. PANDIT