Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

Abstract: The described technology generally includes systems and processes for a PD optimization process may operate to estimate, predict, or otherwise determine the value of PD dose variables values based on patient characteristics and/or PD prescription information. In one embodiment, a PD optimization process may be or may include a UFV determination process, operative to determine a predicted UFV for a patient. In some embodiments, the UFV determination process may include training a computational model to generate a predicted UFV output based on input of patient characteristics, PD prescription information, PD outcomes (for instance, UFV), and/or historical information associated with patient characteristics, PD prescription information, and/or PD outcomes. In some embodiments, a feedback control process with continuous Intraperitoneal Pressure (IPP) and hydration status measurements may be used to keep the hydration status of the patient within a target level ran. Other embodiments are described.

Abstract: Compounds, systems, kits, methods, and/or apparatuses may be operative to reduce amyloid beta (A?) peptide in a patient, including a central nervous system (CNS) of the patient and/or a periphery (non-CNS portion) of the patient. In some embodiments, a displacer fluid comprising a A? displacer may be introduced to the patient to bind to a blood protein, such as albumin, that binds A? (for instance, A? peptide or non-plaque A?) in the patient periphery. Binding of the displacer to the blood protein may facilitate more free A? peptide (for instance, A? monomers) in the periphery for clearance via natural processes, such as through the liver or kidneys, and/or artificial processes, such as dialysis. Increased removal of the free A? peptide in the periphery may ultimately lead to less A? peptide in the CNS, which may decrease A? plaque formation in Alzheimer's Disease (AD) patients. Other embodiments are described.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

Abstract: Techniques and apparatuses for access recirculation of a patient during dialysis treatment are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to determine a first hemoglobin concentration for a dialysis system, determine a change in an ultrafiltration rate, determine a second hemoglobin concentration modified due to the change in the ultrafiltration rate based on a dialysis system model of the dialysis system, and determine an access recirculation value for the dialysis system. Other embodiments are described.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

Abstract: A divider circuit and method for generating one or more digital signals is presented. The circuit has a first output section for generating a first digital signal. There is a first output section with an output node to output the first digital signal, and a plurality of switches with one or more control switches. The plurality of switches selectively couple the output node to a first voltage and/or to selectively couple the output node to a second voltage, thereby generating the first digital signal. The or each control switch is prevents at least one of (i) the output node being coupled to the first and second voltages simultaneously and (ii) the output node being decoupled from both the first and second voltages simultaneously.

Abstract: Techniques and apparatuses for access recirculation of a patient during dialysis treatment are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to determine a first hemoglobin concentration for a dialysis system, determine a change in an ultrafiltration rate, determine a second hemoglobin concentration modified due to the change in the ultrafiltration rate based on a dialysis system model of the dialysis system, and determine an access recirculation value for the dialysis system. Other embodiments are described.

Abstract: A divider circuit determines whether an input factor (N) is an even number or an odd number. If N is an even number then the input clock is divided by N/2 to generate an intermediate clock. The intermediate clock is further divided by two to generate a div-by-2 clock, which is provided as the output clock with fifty percent duty cycle. If N is an odd number, the input clock is divided by (N/2?0.5) in a first duration and by (N/2+0.5) in a second duration to generate the intermediate clock, which is then divided by two to generate the div-by-2 clock. A delayed clock is generated from the div-by-2 clock, wherein the delayed clock lags the div-by-2 clock by half cycle duration of the input clock. The div-by-2 clock and the delayed clock are combined to generate the output clock with fifty percent duty cycle.

Abstract: A divider circuit determines whether an input factor (N) is an even number or an odd number. If N is an even number then the input clock is divided by N/2 to generate an intermediate clock. The intermediate clock is further divided by two to generate a div-by-2 clock, which is provided as the output clock with fifty percent duty cycle. If N is an odd number, the input clock is divided by (N/2?0.5) in a first duration and by (N/2+0.5) in a second duration to generate the intermediate clock, which is then divided by two to generate the div-by-2 clock. A delayed clock is generated from the div-by-2 clock, wherein the delayed clock lags the div-by-2 clock by half cycle duration of the input clock. The div-by-2 clock and the delayed clock are combined to generate the output clock with fifty percent duty cycle.

Abstract: A programmable frequency divider includes a cascade of frequency-dividing units, each capable of dividing by a first or a second factor. Each unit receives an input clock and generates a divided output clock. Each unit receives a mode control signal that specifies when to divide its input clock by the second factor if a control input allows it, otherwise dividing the input clock by the first factor. The frequency divider is designed to support a range of divide ratios that requires one or more of the units to be non-operative or unused in some intervals. The final divided clock is generated using the mode control signal of the lowest unit in the cascade and the mode control signal of the highest unit that is never set to be non-operative or unused in supporting the range. As a result, duty-cycle variations of the final divided clock are minimized.