Patents by Inventor Val J. Lowe

Val J. Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PET imaging of zinc transport
    Patent number: 11103602
    Abstract: A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to ?-amyloid in the patient, and acquiring an image to detect the presence or absence of ?-amyloid in the patient. A method for detecting or ruling out cancer in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to tissue in the patient; and acquiring an image using a medical imaging technique to detect zinc distribution in tissue in the patient.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: August 31, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Timothy R. Degrado, Mukesh K. Pandey, Hendrik Petrus Engelbrecht, Val J. Lowe
  • Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
    Patent number: 10980900
    Abstract: Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography/computed tomography are disclosed.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: April 20, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
    Patent number: 10940218
    Abstract: A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: March 9, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
    Publication number: 20190322723
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier
    Patent number: 10377813
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 13, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • PET IMAGING OF ZINC TRANSPORT
    Publication number: 20190209716
    Abstract: A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to ?-amyloid in the patient, and acquiring an image to detect the presence or absence of ?-amyloid in the patient. A method for detecting or ruling out cancer in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to tissue in the patient; and acquiring an image using a medical imaging technique to detect zinc distribution in tissue in the patient.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 11, 2019
    Inventors: Timothy R. Degrado, Mukesh K. Pandey, Hendrik Petrus Engelbrecht, Val J. Lowe
  • Pet imaging of zinc transport
    Patent number: 10279054
    Abstract: A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to beta-amyloid in the patient, and acquiring an image to detect the presence or absence of beta-amyloid in the patient.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: May 7, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Timothy R. Degrado, Mukesh K. Pandey, Hendrik Petrus Engelbrecht, Val J. Lowe
  • Treatment of Meningiomas Using Phenylbenzothiazole, Stilbene, Biphenylalkyne, or Pyridine Derivitives
    Publication number: 20170196999
    Abstract: A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas.
    Type: Application
    Filed: March 29, 2017
    Publication date: July 13, 2017
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
    Publication number: 20170145076
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier
    Patent number: 9597408
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: March 21, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Erik W. Mahlum
  • PET IMAGING OF ZINC TRANSPORT
    Publication number: 20160175465
    Abstract: A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to beta-amyloid in the patient, and acquiring an image to detect the presence or absence of beta-amyloid in the patient.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 23, 2016
    Inventors: Timothy R. DEGRADO, Mukesh K. PANDEY, Hendrik Petrus ENGELBRECHT, Val J. LOWE
  • Imaging of Meningiomas Using Phenylbenzothiazole, Stilbene, or Biphenylalkyne Derivatives
    Publication number: 20160144060
    Abstract: Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography/computed tomography are disclosed.
    Type: Application
    Filed: December 29, 2015
    Publication date: May 26, 2016
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
    Patent number: 9259495
    Abstract: Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography/computed tomography are disclosed.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: February 16, 2016
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • TREATMENT OF MENINGIOMAS USING PHENYLBENZOTHIAZOLE, STILBENE, BIPHENYLALKYNE, OR PYRIDINE DERIVATIVES
    Publication number: 20150157744
    Abstract: A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative is a compound of formula (V).
    Type: Application
    Filed: June 26, 2013
    Publication date: June 11, 2015
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
    Publication number: 20140328866
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: May 19, 2014
    Publication date: November 6, 2014
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Erik W. Mahlum
  • IMAGING OF MENINGIOMAS USING PHINGYLBENZOTHIAZOLE, STILBENE, OR BIPHENYLALKYNE DERIVATIVES
    Publication number: 20130266513
    Abstract: Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography/computed tomography are disclosed.
    Type: Application
    Filed: October 11, 2011
    Publication date: October 10, 2013
    Inventors: Geoffrey B. Johnson, Val J. Lowe, Mark A. Nathan, Joseph E. Parisi
  • PEPTIDE-MEDIATED NON-COVALENT DELIVERY OF ACTIVE AGENTS ACROSS THE BLOOD-BRAIN BARRIER
    Publication number: 20120107243
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: July 14, 2010
    Publication date: May 3, 2012
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum