Patents by Inventor Val J. Watts

Val J. Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210100797
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 8, 2021
    Applicant: Purdue Research Foundation
    Inventors: Daniel P. Flaherty, Richard M. van Rijn, Val J. Watts, Jason A. Scott
  • Publication number: 20200239447
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 30, 2020
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Patent number: 10662176
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: May 26, 2020
    Assignee: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • Publication number: 20200031785
    Abstract: This present application disclosed a method for the treatment of treating pain, opioid dependence, alcohol use disorder or autism comprising the step of administering to a mammal in need thereof a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutically acceptable salt thereof, and one or more carriers, diluents, or excipients. Those compounds are selective adenylyl cyclase 1 (AC1) inhibitors, which may provide an effective method of treatment for chronic/inflammatory pain, and prevent opioid dependence and/or reduce opioid dependence.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 30, 2020
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Patent number: 10457653
    Abstract: This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors, compounds having a formula or a pharmaceutically acceptable salt thereof, as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 29, 2019
    Assignee: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Publication number: 20190023688
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: July 18, 2018
    Publication date: January 24, 2019
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • Publication number: 20190002418
    Abstract: This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 3, 2019
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • Patent number: 10144700
    Abstract: The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: December 4, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Mingji Dai, Val J. Watts, Zhishi Ye
  • Patent number: 10100001
    Abstract: The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: October 16, 2018
    Assignee: Purdue Research Foundation
    Inventors: Mingji Dai, Val J. Watts, Zhishi Ye
  • Publication number: 20180230080
    Abstract: The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.
    Type: Application
    Filed: March 14, 2018
    Publication date: August 16, 2018
    Applicant: Purdue Research Foundation
    Inventors: Mingji Dai, Val J. Watts, Zhishi Ye
  • Publication number: 20160272572
    Abstract: The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.
    Type: Application
    Filed: February 16, 2016
    Publication date: September 22, 2016
    Inventors: Mingji Dai, Val J. Watts, Zhishi Ye
  • Patent number: 9359303
    Abstract: Octahydrobenzoisoquinoline modulators of dopamine receptors are described herein. Methods for using octahydrobenzoisoquinoline modulators of dopamine receptors in the treatment of dopamine dysfunction are also described herein.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: June 7, 2016
    Assignee: Purdue Research Foundation
    Inventors: David E. Nichols, Val J. Watts
  • Publication number: 20140350081
    Abstract: An approach to identify and evaluate potential insecticide targets using publicly available genome (DNA) sequence information for arthropod disease vector is provided. The utility of this approach is demonstrated by first determining the molecular and pharmacological properties of two different dopamine (neurotransmitter) receptors identified in the genome of the yellow fever- and dengue-transmitting mosquito, Aedes aegypti. Next, different chemistries were tested for their ability to interact with one of these dopamine receptors in a chemical compound screen, and “hit” compounds were identified. Finally, it is shown that some of these chemistries, are selective for the mosquito over the human dopamine receptor and that these chemistries caused significant mortality in mosquito larvae 24 hours after exposure.
    Type: Application
    Filed: November 5, 2012
    Publication date: November 27, 2014
    Inventors: Catherine A. Hill, Val J. Watts
  • Patent number: 8318938
    Abstract: Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: November 27, 2012
    Assignee: Purdue Research Foundation
    Inventors: David Nichols, Val J. Watts
  • Publication number: 20120041018
    Abstract: Octahydrobenzoisoquinoline modulators of dopamine receptors are described herein. Methods for using octahydrobenzoisoquinoline modulators of dopamine receptors in the treatment of dopamine dysfunction are also described herein.
    Type: Application
    Filed: April 21, 2010
    Publication date: February 16, 2012
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: David E. Nichols, Val J. Watts
  • Publication number: 20090030025
    Abstract: Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.
    Type: Application
    Filed: August 20, 2008
    Publication date: January 29, 2009
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: David Nichols, Val J. Watts