Patents by Inventor Valérie DARDALHON

Valérie DARDALHON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF SELECTING T CELLS WITH IMPROVED ANTI-CANCER ACTIVITY
    Publication number: 20240003870
    Abstract: A method of selecting T cells with improved anti-cancer activity, the method including: a) quantifying glucose transporter 1 (GLUT1) expression level at the cell surface of a population of T cells by using a GLUT1 ligand, b) selecting T cells having a low GLUT1 expression level, wherein the T cells having a low GLUT1 expression level have improved anti-cancer activity. Also, a population of T cells with improved anti-cancer activity for use in the treatment of cancer, to the use of a GLUT1 ligand for selecting T cells with improved anti-cancer activity, and to the use of GLUT1 as a biomarker of the anti-cancer therapeutic efficacy of T cells.
    Type: Application
    Filed: November 5, 2021
    Publication date: January 4, 2024
    Applicants: METAFORA BIOSYSTEMS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, THE UNITED STATES OF AMERICA ,ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE
    Inventors: Naomi TAYLOR, Marie Charlotte Chantal POUZOLLES, Valérie DARDALHON, Vincent PETIT
  • METHODS FOR MODULATING A POPULATION OF MYELOID-DERIVED SUPPRESSOR CELLS AND USES THEREOF
    Publication number: 20110059106
    Abstract: The invention provides for methods of modulating a population of myeloid-derived suppressor cells (MDSCs) in a subject, for treating an autoimmune disease, and also treating cancer in a subject in need thereof. The methods comprise administering to the subject a therapeutically effective amount of an agent that modulates the Tim-3 pathway. The Tim-3 pathway can be activated by a Tim-3 ligand, galectin-9, whereby MDSCs are expanded, or inhibited by an antibody to Tim-3, wherein the expansion of MDSCs is inhibited.
    Type: Application
    Filed: January 29, 2009
    Publication date: March 10, 2011
    Applicant: BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Vijay K. Kuchroo, Ana Carrizosa Anderson, Valerie Dardalhon