Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.

Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.

Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.

Abstract: Provided is a composition comprising a first mRNA construct comprising a first open reading frame (ORF), wherein the first ORF encodes an antigen; wherein the first ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least a first organ protection sequence (OPS), and wherein the first OPS comprises at least two micro-RNA (miRNA) target sequences, wherein each of the at least two miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. Also provided are further compositions comprising mRNA constructs comprising an ORF and an OPS wherein the ORF encodes a proinflammatory cytokine, and methods including one or both of these compositions for the treatment and prevention of disease such as pathogenic disease.

Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.

Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.

Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.

Abstract: Bow loading system to be installed on a forecastle deck of a first ship and comprising at least one fluid conveying pipe (118) having a valve coupler (112) at the first end of each pipe, which is intended to be connected to a complementary valve of a fluid conveying pipe of a support structure installed on a second ship; a fixed structure (120) to be fixed on the deck and forming an ascending ramp (122); a movable structure (140) movably mounted on the ramp (122) of the fixed structure and to which is linked each fluid conveying pipe (118) for moving the valve coupler (112) of each pipe from a retracted position to an extended position, in which the complementary valve can be connected to the valve coupler, and means (150) for moving the movable structure (140) from the retracted position to the extended position.

Abstract: Bow loading system to be installed on a forecastle deck of a first ship and comprising at least one fluid conveying pipe (118) having a valve coupler (112) at the first end of each pipe, which is intended to be connected to a complementary valve of a fluid conveying pipe of a support structure installed on a second ship; a fixed structure (120) to be fixed on the deck and forming an ascending ramp (122); a movable structure (140) movably mounted on the ramp (122) of the fixed structure and to which is linked each fluid conveying pipe (118) for moving the valve coupler (112) of each pipe from a retracted position to an extended position, in which the complementary valve can be connected to the valve coupler; and means (150) for moving the movable structure (140) from the retracted position to the extended position.