Patents by Inventor Valder Arruda

Valder Arruda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF CHIMERIC ALLOANTIGEN RECEPTOR T CELLS
    Publication number: 20220220188
    Abstract: The invention includes compositions comprising at least one chimeric alloantigen receptor (CALLAR) specific for an alloantibody, vectors comprising the same, compositions comprising CALLAR vectors packaged in viral particles, and recombinant T cells comprising the CALLAR. The invention also includes methods of making a genetically modified T cell expressing a CALLAR, wherein the expressed CALLAR comprises a Factor VIII or fragment thereof extracellular domain.
    Type: Application
    Filed: August 23, 2021
    Publication date: July 14, 2022
    Inventors: Michael C. MILONE, Valder ARRUDA, Sarah RICHMAN, Benjamin SAMELSON-JONES
  • Compositions and methods for enhancing coagulation factor VIII function
    Patent number: 10442850
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: October 15, 2019
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Valder Arruda, Rodney M. Camire, Nicholas Iacobelli
  • COMPOSITIONS AND METHODS OF CHIMERIC ALLOANTIGEN RECEPTOR T CELLS
    Publication number: 20190153064
    Abstract: The invention includes compositions comprising at least one chimeric alloantigen receptor (CALLAR) specific for an alloantibody, vectors comprising the same, compositions comprising CALLAR vectors packaged in viral particles, and recombinant T cells comprising the CALLAR. The invention also includes methods of making a genetically modified T cell expressing a CALLAR, wherein the expressed CALLAR comprises a Factor VIII or fragment thereof extracellular domain.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 23, 2019
    Inventors: Michael C. MILONE, Valder ARRUDA, Sarah RICHMAN, Benjamin SAMELSON-JONES
  • COMPOSITIONS AND METHODS FOR ENHANCING COAGULATION FACTOR VIII FUNCTION
    Publication number: 20170369554
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Application
    Filed: June 5, 2017
    Publication date: December 28, 2017
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Valder ARRUDA, Rodney M. CAMIRE, Nicholas IACOBELLI
  • Compositions and methods for enhancing coagulation factor VIII function
    Patent number: 9670267
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: June 6, 2017
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Valder Arruda, Rodney Camire, Nicholas Iacobelli
  • COMPOSITIONS AND METHODS FOR ENHANCING COAGULATION FACTOR VIII FUNCTION
    Publication number: 20150056271
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Application
    Filed: August 25, 2014
    Publication date: February 26, 2015
    Inventors: Valder Arruda, Rodney Camire, Nicholas Iacobelli
  • Compositions and methods for enhancing coagulation Factor VIII function
    Patent number: 8816054
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: August 26, 2014
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Valder Arruda, Rodney M. Camire, Nicholas Iacobelli
  • Isolated nucleic acids encoding activated factor V and methods for production thereof
    Patent number: 8470557
    Abstract: Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: June 25, 2013
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Rodney Camire, Valder Arruda
  • Compositions and Methods for Enhancing Coagulation Factor VIII Function
    Publication number: 20120308641
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Application
    Filed: April 2, 2012
    Publication date: December 6, 2012
    Inventors: Valder Arruda, Rodney M. Camire, Nicholas Iacobelli