Patents by Inventor Valder R. Arruda

Valder R. Arruda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Modulating Factor IX Function
    Publication number: 20230250412
    Abstract: Factor IX/IXa variants and methods of use thereof are disclosed.
    Type: Application
    Filed: March 1, 2023
    Publication date: August 10, 2023
    Inventors: Valder R. Arruda, Rodney M. Camire, Benjamin Samelson-Jones
  • Compositions and methods for modulating Factor IX function
    Patent number: 11708570
    Abstract: Factor IX/IXa variants and methods of use thereof are disclosed.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: July 25, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Valder R. Arruda, Rodney M. Camire, Benjamin Samelson-Jones
  • COMPOSITIONS AND METHODS FOR MODULATING FACTOR VIII FUNCTION
    Publication number: 20220033475
    Abstract: Factor VIII variants and methods of use thereof are disclosed.
    Type: Application
    Filed: October 23, 2019
    Publication date: February 3, 2022
    Inventors: Valder R. Arruda, Benjamin Samelson-Jones
  • Compositions and Methods for Modulating Factor IX Function
    Publication number: 20200248161
    Abstract: Factor IX/IXa variants and methods of use thereof are disclosed.
    Type: Application
    Filed: July 27, 2017
    Publication date: August 6, 2020
    Inventors: Valder R. Arruda, Rodney M. Camire, Benjamin Samelson-Jones
  • Compositions and methods for modulating factor IX function
    Patent number: 10676731
    Abstract: Factor IX/IXa variants and methods of use thereof are disclosed.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: June 9, 2020
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Rodney M. Camire, Lacramioara Ivanciu, Valder R. Arruda
  • Compositions and Methods for Modulating Factor IX Function
    Publication number: 20190024071
    Abstract: Factor IX/IXa variants and methods of use thereof are disclosed.
    Type: Application
    Filed: August 19, 2015
    Publication date: January 24, 2019
    Inventors: Rodney M. Camire, Lacramioara Ivanciu, Valder R. Arruda
  • Protein C Zymogen and Methods of Use Thereof to Prevent Cancer Metastases
    Publication number: 20130078302
    Abstract: Compositions and methods useful for the inhibition of cancer metastasis are disclosed.
    Type: Application
    Filed: August 27, 2012
    Publication date: March 28, 2013
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Valder R. Arruda, Katherine A. High, Geerte Van Sluis, Christoffel Arnoldus Spek
  • Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V
    Publication number: 20120288895
    Abstract: Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
    Type: Application
    Filed: July 25, 2012
    Publication date: November 15, 2012
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Rodney M. Camire, Valder R. Arruda
  • Methods for treating a hemostasis related disorder using activated forms of Factor V
    Patent number: 8236764
    Abstract: Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: August 7, 2012
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Rodney M. Camire, Valder R. Arruda
  • Methods for preventing formation of inhibitory antibodies in the setting of gene therapy
    Patent number: 8063022
    Abstract: The invention provides a method of preventing the formation of inhibitory antibodies in a mammal undergoing gene therapy. The method comprises administering to the mammal an immunosuppressive agent in conjunction with the gene therapy.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: November 22, 2011
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Paul A. Fields, Valder R. Arruda, Roland W. Herzog
  • COMPOSITIONS AND METHODS FOR MODULATING HEMOSTASIS USING VARIANT FORMS OF ACTIVATED FACTOR V
    Publication number: 20090318344
    Abstract: Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
    Type: Application
    Filed: February 23, 2007
    Publication date: December 24, 2009
    Inventors: Rodney M. Camire, Valder R. Arruda
  • Induction of tolerance to a therapeutic polypeptide
    Publication number: 20030130221
    Abstract: Liver-directed gene transfer can induce immunological tolerance to a polypeptide associated with the expression of a therapeutic nucleic acid. Hepatic expression of a transgene induces tolerance to the expression product of the transgene, or to post-translational product related to transgene expression, thereby ameliorating or eliminating the immune responses associated with gene therapy and protein replacement, respectively, independent of the genetic background of the subject.
    Type: Application
    Filed: November 5, 2002
    Publication date: July 10, 2003
    Applicant: Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Roland W. Herzog, Valder R. Arruda