Abstract: The present disclosure provides methods and systems for detecting or analyzing a biomolecule. The methods and systems may comprise the use of a plurality of electrodes and a solution which may comprise a variety of reagents. In an example, the solution may comprise one or more redox-active molecules or compounds which may undergo or facilitate a redox cycling process. The redox cycling process may generate an electric signal that may be measured by one or more of the plurality of electrodes. An introduction of a nucleotide having a redox cycling current modifying particle coupled thereto to the solution may result in a change in the electric signal. The change in the electric signal may be used to identify the biomolecule or a portion thereof.

Abstract: The invention relates to devices and methods for hybridization assisted sequencing of biomolecule analytes in nanopores, nano-channels and micro-channels. An alternating current signal may be employed to achieve a significantly improved signal-to-noise ratio, thereby enhancing system performance.