Abstract: A method of assessing the impact of a certain treatment strategy for a patient on a digital twin or virtual model of that patient. It is recognized that the impact on a virtual twin could determine whether or not a treatment strategy is selected, as clinicians are becoming increasingly reliant on virtual twins to perform long-term monitoring of a patient's condition.

Abstract: Embodiments are described herein for training machine learning models using digital twin outputs, including for purposes of pain quantification and estimation. In various embodiments, simulation parameter(s) may be applied to a digital twin created for a subject. The digital twin may simulate an anatomical structure of the subject, and the simulation parameter(s) may cause the digital twin to generate digital twin output that simulates behavior of the anatomical structure in response to the one or more simulation parameters. Data indicative of the digital twin output may be applied as input across a pain estimation machine learning model to generate pain estimation output. Based on the pain estimation output, a quantification of pain, e.g., an estimated pain score, may be rendered using an output device and/or used to select a treatment plan.

Abstract: A oral irrigator device (10) for cleaning teeth, including a system (14) for producing a stream of liquid/air bursts and a nozzle (16) connected to the system, and through which the stream of liquid/air bursts are directed. The nozzle can include a guidance tip (26) including a base portion (30), a tip portion (28), and an orifice (31) through which the stream of liquid/air bursts exits at a flow output pattern, and a flow output pattern selection mechanism (90, 90?) connected to or positioned within the guidance tip. A flow output pattern selection mechanism can be configured to be selectively actuated and to vary, upon the actuation the flow output pattern between a first flow output pattern to at least a second flow output pattern.

Abstract: A nozzle (12) for an oral irrigator device (10) having a guidance tip (34) with at least one orifice (36) at one end, and a nozzle spacer assembly (58) positioned around the at least one orifice (36). The at least one orifice is configured to expel a fluid as one of a jet, a spray, or any combination thereof. The nozzle spacer assembly (58) comprises at least two pairs of pliable spacers (60) that extend from the surface (35) for ensuring that the area at an entrance of an interproximal space between two teeth are treated, and (ii) establishing an improved angle of impact of the fluid expelled from the orifice.

Abstract: An actuator device comprises an EAP structure which deforms in response to a drive signal applied to the device, a device output being derived from movement of the EAP structure. A delay arrangement is used such that the mechanical output from the device is not generated for a first range or type of applied drive signals, and said device output is generated for a second range or type of applied drive signals. This device is for example particularly suitable for use in a passive matrix system.

Abstract: A system for predicting the onset of a physiological condition of a subject combines an in-vitro subject model having input parameters relating to actual or predicted external stimuli to which the subject is or may be exposed and an in-silico model. The in-vitro model outputs subject-specific parameters which are not being monitored, or cannot be monitored, in-vivo. The in-silico subject model uses subject-specific parameters to predict the response of the subject to the actual or predicted external stimuli and thereby predict an onset of a physiological condition of the subject.

Abstract: Disclosed is a method (100) of providing a personalized parameter model of at least part of the physiology of a person (10) carrying a set of sensors (12, 14, 16) with a computer system (20, 50) comprising a processor arrangement (22, 52) for the purpose of updating a biophysical model or digital twin of the person. The method comprises, with said processor arrangement, receiving (103) sensor data from said set of sensors with the communication interface over a defined period of time, the sensor data from each sensor representing a parameter relevant to an actual physiological state of the person; evaluating (105) the received sensor data from each sensor to define the personalized parameter model (3), said model including the evaluated dynamic behaviour of the values of each parameter observed with said sensors over the defined period of time and providing (107) the defined personalized parameter model for updating a digital model (1) of at least part of the anatomy of said person.

Abstract: A bending actuator device or sensor device for sensing bending comprises a stack of electroactive polymer units. The adjacent electroactive polymer units in the stack are slidable relatively to each other. This means that, for an actuator for example, an increased actuation force is enabled without requiring increased driving voltage, and it also avoids the problems of stress build up by allowing sliding between the units.

Abstract: An oral cleaning device comprises a body which carries a set of projections. An actuator device is associated with one or more of the projections in the form of an electroactive polymer structure for adjusting a position of the associated one or more projections. This enables dynamic control of the cleaning function.

Abstract: The invention relates to a mouthpiece for performing a treatment of teeth such as teeth whitening. Accordingly, the mouthpiece may be arranged for cosmetic treatment. The treatment is based on illumination of the teeth of light with a suitable wavelength. The mouthpiece is designed so that light from light sources, e.g. LED's, is sufficiently homogenized so that the light irradiance at the teeth is sufficiently uniform to achieve good treatment results. Furthermore, the mouthpiece is designed so that the irradiance at the teeth is sufficiently high to achieve efficient treatment and so that heating of the teeth is minimized to an acceptable heating.

Abstract: A cleaning device (10) comprising: a body portion (12); a nozzle member (14) mounted on the body portion and comprising a nozzle head (16), wherein the nozzle member is configured to allow passage of liquid and/or air from a reservoir in the body to the nozzle head; and an orifice (40) in the nozzle head configured to allow the liquid and/or air to exit the nozzle head, wherein the orifice is configured to shape the exiting liquid and/or air into at least one liquid sheet having a length greater than a width at a target cleaning distance.

Abstract: A method is disclosed of developing a personalized digital model of at least part of the anatomy of a person with a computer system comprising a processor arrangement and a communication module under control of the processor arrangement.

Abstract: Disclosed is a computer system (20) comprising a processor arrangement (22) communicatively coupled to a data storage arrangement (30) storing a virtual model of a patient, said virtual model comprising at least one of a digital representation of at least a part of the anatomy of the patient and a physiological model of a bodily process of the patient; and a communication module (24) communicatively coupled to said processor arrangement and arranged to receive sensor data from one or more sensors (12, 14, 16) arranged to monitor said patient, wherein the processor arrangement is arranged to retrieve (103) said virtual model from the data storage arrangement; receive (105) said sensor data from the communication module; evaluate said sensor data with said virtual model; generate (111, 121) an instruction for altering a mode of operation of at least one sensor of the one or more sensors in response to said evaluation or in response to a user request; and transmit said instruction to the at least one sensor or t

Abstract: A computer system is disclosed comprising a processor arrangement communicatively coupled to a data storage arrangement storing a digital model of a section of a lumen system of a patient; and a communication module communicatively coupled to said processor arrangement and arranged to receive sensor data pertaining to an internal parameter of said lumen system from a sensor within said section of the lumen system. The processor arrangement is arranged to receive said sensor data from the communication module; retrieve said digital model from the data storage arrangement; simulate an actual physical condition of said lumen system by developing said digital model based on the received sensor data; and generate an output relating to said simulated actual physical condition for updating an electronic device. Also disclosed is a method of monitoring a patient with such a computer system, a computer program product for implementing such a method and a patient monitoring system.

Abstract: A nozzle (12) for an oral irrigator device (10) having a guidance tip (34) with an orifice at one end, and a dynamic nozzle actuator (64) positioned within said guidance tip. The orifice (36) is configured to expel a fluid as one of a jet, a spray, or any combination thereof. The dynamic nozzle actuator (64) comprises at least one responsive material adapted for being energized and configured to implement at least one dynamic actuation of an effective channel (62) for dynamically influencing at least one of (i) a direction of fluid expelled from the orifice (36), (ii) an angle of fluid expelled from the orifice (36), (iii) a cross-sectional width of fluid expelled from the orifice (36), and (iv) any combination thereof.

Abstract: A method and system for determining an amount of risk an air pollutant poses to a subject. A risk level is calculated by determining a dosage of the air pollutant, received by the subject over a predetermined period of time, and obtaining historic information about historic dosages of the air pollutant. The risk level is then calculated using the dosage and the historic information to thereby determine a risk level associated with the accumulated deposition of the air pollutant in the portion of the subject's respiratory tract.

Abstract: Attachment assemblies for oral hygiene devices and, in particular, attachment assemblies having improved designs to more effectively clean an individual's tongue or other inter-oral surface are described herein. These improved attachment assembly correspond, amongst other aspects, to improved fluid chamber configurations, improved fluid channel configurations, improved fluid exit hole configurations, improved air inlet hole configuration, and air channel features. Furthermore, these improvements to attachment assemblies are capable of being implemented separately from, or in combination with, one another.

Abstract: A first component (16) for a personal care device comprises a first coupling interface for allowing the first component (16) to be releasably and repeatably coupled to a second component for the personal care device via a second coupling interface of the second component. The first coupling interface comprising a portion of material (38) that can change shape with changes in temperature to couple the first coupling interface to the second coupling interface. The portion of the material (38; 60) is configured to deform during coupling and uncoupling, and to revert towards an original shape after the first coupling interface and the second coupling interface have been coupled or uncoupled. The invention also provides a personal care device (10) comprising the first component (16; 12), and the second component (12; 16) having the second coupling interface.

Abstract: The invention provides a shape change device (20) utilising a plurality of particles (28) of electroactive polymer material embedded within a compliant material matrix (24) and adapted to deform in response to application of an electrical stimulus. A resultant shape-change of the compliant matrix enables realisation of a particular deformation profile across a surface of the compliant material. Particles are stimulated in plural groups by one or more arrangements of electrodes (34). Shapes, sizes, dimensionalities and locations of stimulated EAP particle regions may be selectively chosen to initiate a particular response in the material, and produce a particular desired deformation profile across the material surface.

Abstract: Attachment assemblies for oral hygiene devices and, in particular, attachment assemblies having improved designs to more effectively clean an individual's tongue or other inter-oral surface are described herein. These improved attachment assembly correspond, amongst other aspects, to improved fluid chamber configurations, improved fluid channel configurations, improved fluid exit hole configurations, improved air inlet hole configuration, and air channel features. Furthermore, these improvements to attachment assemblies are capable of being implemented separately from, or in combination with, one another.