Patents by Inventor Valeri Metelev

Valeri Metelev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid oligonucleotide phosphorothioates
    Patent number: 7045609
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2?-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: May 16, 2006
    Assignee: University of Massachusetts Worcester
    Inventors: Valeri Metelev, Sudhir Agrawal
  • Hybrid oligonucleotide phosphorothioates
    Patent number: 6683167
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: January 27, 2004
    Assignee: University of Massachusetts Worcester
    Inventors: Valeri Metelev, Sudhir Agrawal
  • Hybrid oligonucleotide phosphorothioates
    Publication number: 20030148980
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Application
    Filed: October 8, 2002
    Publication date: August 7, 2003
    Applicant: Worcester Foundation for Experimental Biology
    Inventors: Valeri Metelev, Sudhir Agrawal
  • Hybrid oligonucleotide phosphorothioates
    Publication number: 20020099192
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Application
    Filed: June 22, 2001
    Publication date: July 25, 2002
    Applicant: Worcester Foundation for Experimental Biology
    Inventors: Valeri Metelev, Sudhir Agrawal
  • Hybrid oligonucleotide phosphorothioates
    Patent number: 6346614
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: February 12, 2002
    Assignee: Hybridon, Inc.
    Inventors: Valeri Metelev, Sudhir Agrawal
  • Oligonucleotides active against drug-resistant bacteria
    Patent number: 6335436
    Abstract: The invention discloses methods and materials for the utilization of chemically modified oligonucleotides in the treatment of drug-resistant bacterial infections including drug-resistant tuberculosis.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: January 1, 2002
    Assignee: Hybridon, Inc.
    Inventors: Eliezer Rapaport, Valeri Metelev, Paul C. Zamecnik
  • Hybrid oligonucleotide phosphorothioates
    Patent number: 6143881
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 7, 2000
    Assignee: University of Massachusetts Worcester
    Inventors: Valeri Metelev, Sudhir Agrawal
  • Hybrid oligonucleotide phosphorothioates
    Patent number: 5652355
    Abstract: The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonueleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
    Type: Grant
    Filed: July 23, 1992
    Date of Patent: July 29, 1997
    Assignee: Worcester Foundation for Experimental Biology
    Inventors: Valeri Metelev, Sudhir Agrawal