Patents by Inventor Valeria Boi

Valeria Boi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MANUFACTURING OF DIMERIC CONTRAST AGENTS
    Publication number: 20230303592
    Abstract: The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [?-[1-[bis[2-(hydroxy-kO)-3-[4,7,10-tris[(carboxy-kO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-kN1,kN4,kN7,kN10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot and without isolation of the obtained intermediate.
    Type: Application
    Filed: July 26, 2021
    Publication date: September 28, 2023
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Andrea BARALE, Valeria BOI, Aurelia FERRIGATO, Sonia GAZZETTO, Daniela GIARDINA-PAPA, Armando MORTILLARO, Laura ORIO, Massimo VERANI
  • Dimeric contrast agents
    Patent number: 11401262
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: August 2, 2022
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • Contrast agents
    Patent number: 11021451
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: June 1, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Contrast agents
    Patent number: 11007283
    Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 18, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • DIMERIC CONTRAST AGENTS
    Publication number: 20210024500
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: October 1, 2020
    Publication date: January 28, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • Dimeric contrast agents
    Patent number: 10882849
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 5, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • DIMERIC CONTRAST AGENTS
    Publication number: 20200331893
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: July 25, 2019
    Publication date: October 22, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • CONTRAST AGENTS
    Publication number: 20200325108
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • Dimeric contrast agents
    Patent number: 10793533
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: October 6, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
  • Contrast agents
    Patent number: 10781188
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 22, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • DIMERIC CONTRAST AGENTS
    Publication number: 20200017453
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: December 11, 2017
    Publication date: January 16, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA, Giovanni Battista GIOVENZANA
  • DIMERIC CONTRAST AGENTS
    Publication number: 20190345142
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: July 25, 2019
    Publication date: November 14, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
    Patent number: 10457635
    Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: October 29, 2019
    Assignee: BRACCO IMAGING S.p.A.
    Inventors: Pier Lucio Anelli, Maria Argese, Valeria Boi, Livio Cavalieri, Laura Galimberti, Sonia Gazzetto, Luciano Lattuada, Federico Maisano, Giovanni Rivolta, Fulvia Vella
  • Dimeric contrast agents
    Patent number: 10407412
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 10, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • CONTRAST AGENTS
    Publication number: 20190167819
    Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: April 5, 2017
    Publication date: June 6, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • DIMERIC CONTRAST AGENTS
    Publication number: 20180362511
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 20, 2018
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • CONTRAST AGENTS
    Publication number: 20180362476
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 20, 2018
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine
    Publication number: 20180118669
    Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 3, 2018
    Applicant: BRACCO IMAGING S.p.A.
    Inventors: Pier Lucio ANELLI, Maria ARGESE, Valeria BOI, Livio CAVALIERI, Laura GALIMBERTI, Sonia GAZZETTO, Luciano LATTUADA, Federico MAISANO, Giovanni RIVOLTA, Fulvia VELLA
  • Process for the preparation of a sulfated derivative of 3,5-diiodo-O-[3-iodophenyl]-L-tyrosine
    Patent number: 9890116
    Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: February 13, 2018
    Assignee: BRACCO IMAGING S.p.A.
    Inventors: Pier Lucio Anelli, Maria Argese, Luciano Lattuada, Sonia Gazzetto, Laura Galimberti, Valeria Boi, Livio Cavalieri, Fulvia Vella
  • Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine
    Publication number: 20140221477
    Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pier Lucio ANELLI, Maria ARGESE, Valeria BOI, Livio CAVALIERI, Laura GALIMBERTI, Sonia GAZZETTO, Luciano LATTUADA, Fulvia VELLA