Patents by Inventor Valeria Ossovskaya

Valeria Ossovskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120269861
    Abstract: In one aspect, the present invention provides a method of treating breast cancer that is negative for ER, PR, and HER2, comprising administering to a subject at least one iodonitrobenzamide. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one iodonitrobenzamide in combination with at least one anti-tumor agent.
    Type: Application
    Filed: March 26, 2012
    Publication date: October 25, 2012
    Applicant: BiPar Sciences, Inc.
    Inventors: Barry M. SHERMAN, Charles BRADLEY, Valeria OSSOVSKAYA
  • Publication number: 20120004260
    Abstract: The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
    Type: Application
    Filed: June 27, 2011
    Publication date: January 5, 2012
    Applicant: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, Barry Sherman
  • Patent number: 7723018
    Abstract: The present invention relates to regulation of the cell cycle. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: May 25, 2010
    Assignee: Rigel Pharmaceuticals, Incorporated
    Inventors: Robert Booher, Esteban Masuda, Valeria Ossovskaya, Brian Wong
  • Publication number: 20090291924
    Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.
    Type: Application
    Filed: May 21, 2009
    Publication date: November 26, 2009
    Applicant: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, John Burnier, Barry Sherman, Max Totrov
  • Publication number: 20090149417
    Abstract: The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
    Type: Application
    Filed: October 17, 2008
    Publication date: June 11, 2009
    Inventors: Valeria Ossovskaya, Barry M. Sherman
  • Publication number: 20090149397
    Abstract: In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 11, 2009
    Inventors: Valeria Ossovskaya, Charles Bradley, Barry Sherman
  • Patent number: 7538252
    Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: May 26, 2009
    Assignee: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, John Burnier, Barry Sherman, Max Totrov
  • Publication number: 20090131529
    Abstract: In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
    Type: Application
    Filed: November 11, 2008
    Publication date: May 21, 2009
    Inventors: Barry M. Sherman, Charles Bradley, Valeria Ossovskaya
  • Publication number: 20090123419
    Abstract: In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
    Type: Application
    Filed: November 12, 2008
    Publication date: May 14, 2009
    Inventors: Barry M. Sherman, Charles Bradley, Valeria Ossovskaya
  • Publication number: 20080319054
    Abstract: The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
    Type: Application
    Filed: June 30, 2008
    Publication date: December 25, 2008
    Inventors: Ernest Kun, Jerome Mendeleyev, Carol Basbaum, Hassan Lemjabbar-Alaoui, Valeria Ossovskaya
  • Patent number: 7405227
    Abstract: Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma that has migrated into the abdominal cavity, a transitional cell carcinoma of the bladder, an epithelioid carcinoma in a pancreatic duct, an adenocarcinoma in a pancreatic duct, an adenocarcinoma in the cervical epithelium. The methods comprise administering to a patient a therapeutically effective amount of a compound of formula (Ia) wherein R1, R2, R3, R4, and R5 are described herein, wherein at least two of the five R1, R2, R3, R4, and R5 substituents are always hydrogen, at least one of the five substituents is always nitro, and at least one substituent positioned adjacent to a nitro is always iodo, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: July 29, 2008
    Assignee: BiPAr Sciences, Inc.
    Inventors: Ernest Kun, Jerome Mendeleyev, Carol Basbaurn, Hassan Lemjabbar-Alaoui, Valeria Ossovskaya
  • Publication number: 20080103104
    Abstract: The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
    Type: Application
    Filed: September 5, 2007
    Publication date: May 1, 2008
    Applicant: BiPar Sciences, Inc.
    Inventors: Jerome Moore, Bruce Keyt, John Burnier, Barry Sherman, Max Totrov, Valeria Ossovskaya
  • Publication number: 20080103208
    Abstract: The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
    Type: Application
    Filed: September 5, 2007
    Publication date: May 1, 2008
    Applicant: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, Barry Sherman
  • Publication number: 20080076737
    Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 27, 2008
    Applicant: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, John Burnier, Barry Sherman, Max Totrov
  • Publication number: 20080076778
    Abstract: The present invention relates to a computer-assisted method of a designing of a PARP inhibitor comprising: a) determining an interaction between a candidate PARP protein and a known PARP inhibitor by evaluating a binding of the PARP protein to the known PARP inhibitor; b) based on the interaction, designing a candidate PARP inhibitor; c) determining an interaction between the PARP protein and the candidate PARP inhibitor by evaluating a binding of the PARP protein to the candidate PARP inhibitor; and d) concluding that the candidate PARP inhibitor inhibits the PARP protein wherein the conclusion is based on the interaction of step c). The invention also provides methods for treatment of diseases with the candidate PARP inhibitors.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 27, 2008
    Applicant: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, John Burnier, Barry Sherman, Max Totrov
  • Publication number: 20070292883
    Abstract: The present invention relates to methods of identifying a disease treatable with PARP modulators by identifying a level of PARP in a sample of a subject, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The method further comprises of treating the disease in the subject with the PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with PARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatment with PARP inhibitors. The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively.
    Type: Application
    Filed: June 12, 2007
    Publication date: December 20, 2007
    Inventors: Valeria Ossovskaya, Barry Sherman
  • Patent number: 6887675
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: May 3, 2005
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ying Luo, Eva Chan, Xiang Xu, Betty Huang, Valeria Ossovskaya
  • Publication number: 20050074825
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Application
    Filed: July 8, 2003
    Publication date: April 7, 2005
    Inventors: Ying Luo, Eva Chan, Xiang Xu, Betty Huang, Valeria Ossovskaya
  • Publication number: 20040180353
    Abstract: The present invention relates to regulation of the cell cycle. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.
    Type: Application
    Filed: August 28, 2003
    Publication date: September 16, 2004
    Applicant: Rigel Pharmaceuticals
    Inventors: Robert Booher, Esteban Masuda, Valeria Ossovskaya, Brian Wong
  • Patent number: 6617102
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: September 9, 2003
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ying Luo, Eva Chan, Xiang Xu, Betty Huang, Valeria Ossovskaya