Patents by Inventor Valerie A. Kickhoefer
Valerie A. Kickhoefer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11261471Abstract: Disclosed herein are methods and compositions for making vault particles in yeast hosts and yeast vaults produced therefrom.Type: GrantFiled: May 16, 2019Date of Patent: March 1, 2022Assignees: The Regents of the University of California, Vault Pharma Inc.Inventors: Leonard H. Rome, Shaily Mahendra, Meng Wang, Valerie A. Kickhoefer, Oliver Karl Foellmer
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Patent number: 10780147Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.Type: GrantFiled: February 3, 2017Date of Patent: September 22, 2020Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Publication number: 20190352689Abstract: Disclosed herein are methods and compositions for making vault particles in yeast hosts and yeast vaults produced therefrom.Type: ApplicationFiled: May 16, 2019Publication date: November 21, 2019Inventors: Leonard H. Rome, Shaily Mahendra, Meng Wang, Valerie A. Kickhoefer, Oliver Karl Foellmer
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Patent number: 10166277Abstract: The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.Type: GrantFiled: September 5, 2016Date of Patent: January 1, 2019Assignees: The Regents of the University of California, The United States of America represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Valerie A. Kickhoefer, Sherven Sharma, Steven M. Dubinett, Isaac Yang, Linda M. Liau, Kathleen A. Kelly, Jian Yang, Upendra K. Kar, Cheryl Champion, Janina Jiang
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Patent number: 9951107Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.Type: GrantFiled: September 24, 2015Date of Patent: April 24, 2018Assignees: The Regets of the University of California, The Scripps Research InstituteInventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen Nemerow, Cheng-Yu Lai, Christopher Wiethoff, Mu Han
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Publication number: 20170143797Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.Type: ApplicationFiled: February 3, 2017Publication date: May 25, 2017Applicants: The Regents of the University of California, The United States Government as represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Ph.D., Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Patent number: 9597372Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.Type: GrantFiled: November 25, 2014Date of Patent: March 21, 2017Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Publication number: 20160367653Abstract: The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.Type: ApplicationFiled: September 5, 2016Publication date: December 22, 2016Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Sherven Sharma, Steven M. Dubinett, Isaac Yang, Linda M. Liau, Kathleen A. Kelly, Jian Yang, Upendra K. Kar, Cheryl Champion, Janina Jiang
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Patent number: 9463232Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: GrantFiled: September 24, 2015Date of Patent: October 11, 2016Assignee: The Regents of the University of CaliforniaInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl Champion
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Publication number: 20160068576Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.Type: ApplicationFiled: September 24, 2015Publication date: March 10, 2016Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen Nemerow, Cheng-Yu Lai, Christopher Wiethoff, Mu Han
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Publication number: 20160008452Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: ApplicationFiled: September 24, 2015Publication date: January 14, 2016Inventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl Champion
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Publication number: 20150368671Abstract: A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.Type: ApplicationFiled: July 15, 2015Publication date: December 24, 2015Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Sujna Raval-Fernandes, Phoebe L. Stewart
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Patent number: 9181312Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.Type: GrantFiled: September 4, 2013Date of Patent: November 10, 2015Assignees: The Regents of the University of California, The Scripps Research InstituteInventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Chris M. Weithoff, Mu Ri Han
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Patent number: 9169303Abstract: Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.Type: GrantFiled: July 26, 2014Date of Patent: October 27, 2015Assignee: The Regents of the University of CaliforniaInventors: Valerie A. Kickhoefer, Leonard H. Rome, Kathleen A. Kelly, Cheryl I. Champion
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Patent number: 9114173Abstract: A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.Type: GrantFiled: December 10, 2014Date of Patent: August 25, 2015Assignee: The Regents of the University of CaliforniaInventors: Leonard H. Rome, Valerie A. Kickhoefer, Sujna Raval-Fernandes, Phoebe Stewart
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Publication number: 20150150821Abstract: The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.Type: ApplicationFiled: July 9, 2013Publication date: June 4, 2015Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Sherven Sharma, Steven M. Dubinett, Isaac Yang, Linda M. Liau, Kathleen A. Kelly, Jian Yang, Upendra K. Kar, Cheryl Champion, Janina Jiang
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Publication number: 20150150944Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.Type: ApplicationFiled: November 25, 2014Publication date: June 4, 2015Applicants: The Regents of the University of California, The United States Government Represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Publication number: 20150093334Abstract: A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.Type: ApplicationFiled: December 10, 2014Publication date: April 2, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Leonard H. Rome, Valerie A. Kickhoefer, Sujna Raval-Fernandes, Phoebe Stewart
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Patent number: 8933203Abstract: A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.Type: GrantFiled: October 15, 2008Date of Patent: January 13, 2015Assignee: The Regents of the University of CaliforniaInventors: Leonard H. Rome, Valerie A. Kickhoefer, Raval-Fernandes Sujna, Phoebe L. Stewart
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Patent number: 8920807Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.Type: GrantFiled: November 2, 2010Date of Patent: December 30, 2014Assignees: The Regents of the University of California, The United States of America Represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Valerie A. Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar