Abstract: The invention relates to a model of reconstructed cornea, which may be used especially in tissue engineering, to a biomaterial that may be used for preparing a reconstructed cornea, and also to a culture device allowing better reproducibility of the cultures of the model of reconstructed cornea.

Abstract: The present invention relates to cosmetic preparations comprising novel polyurethanes or mixtures thereof as means for modifying rheological properties.

Abstract: The invention relates to a novel active ingredient that stimulates the proliferation and/or the activity of fibroblasts and also to its applications in the cosmetic or pharmaceutical, in particular dermatological, field. In particular, the active ingredient according to the invention comprises a combination of at least one Hibiscus Abelmoschus extract and a soy extract containing at least peptides.

Abstract: The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers.

Abstract: The present invention relates to the use of active substances that increase the activation threshold of immune cell as an active principle for the preparation of a cosmetic or pharmaceutical composition, especially a dermatological composition. The invention also relates to a method for screening such active substances.

Abstract: The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells or both from CD14+ monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD 14+ monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14+ monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells. The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models.

Abstract: The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the ? opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.

Abstract: The present invention relates to UV filter capsules, to the use thereof for the preparation of cosmetic or dermatological formulations or dispersions, and to cosmetic or dermatological formulations which comprise the capsules, and to a process for the production thereof.

Abstract: The present invention relates to a method for producing cosmetic preparations comprising metal oxide, where the reaction mixture which forms during the production of the particulate metal oxide is incorporated into the cosmetic preparations essentially without further work-up.

Abstract: The present invention relates to photoprotective preparations, in particular in the field of cosmetics, based on inorganic-organic mixed systems. The present invention relates in particular to photoprotective preparations comprising nanoparticles of at least one metal derivative, at least one photoprotective compound chemically bonded to these metal derivative nanoparticles, and at least one further organic UV photoprotective agent which is different from the photoprotective compound bonded to the metal derivative nanoparticles.

Abstract: The present invention relates to methods of producing surface-modified nanoparticulate particles at least of one metal oxide, metal hydroxide and/or metal oxide hydroxide, and aqueous suspensions of these particles. Furthermore, the invention relates to the surface-modified nanoparticulate particles, obtainable by these methods, at least of one metal oxide, metal hydroxide and/or metal oxide hydroxide and aqueous suspensions of these particles, and to their use for cosmetic sunscreen preparations, as stabilizer in plastics and as antimicrobial active ingredient.

Abstract: The present invention relates to surface-modified nanoparticulate metal oxides where the metal is chosen from the group consisting of aluminum, cerium, iron, titanium, zinc and zirconium, wherein the surface modification comprises a coating with a copolymer P comprising, as monomers, A) 1 to 99 mol % of a N-vinylamide N-vinylpyrrolidone and B) 99 to 1 mol % of a monomer comprising, per molecule, a free-radically polymerizable ?,?-ethylenically unsaturated double bond and an anionogenic and/or anionic group, with the proviso that the copolymer P must comprise no further monomers chosen from the group consisting of C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids, N-alkyl- or N,N-dialkyl-substituted amides of acrylic acid or of methacrylic acid with C8-C18-alkyl radicals, or vinyl esters of aliphatic C8-C30-carboxylic acids.

Abstract: The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The Invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers.

Abstract: The present invention relates to methods of producing surface-modified nanoparticulate particles at least of one metal oxide, metal hydroxide and/or metal oxide hydroxide, and aqueous suspensions of these particles. The invention further relates to the surface-modified nanoparticulate particles, obtainable by these methods, at least of one metal oxide, metal hydroxide and/or metal oxide hydroxide and aqueous suspensions of these particles, and to their use for cosmetic sunscreen preparations, as stabilizer in plastics and as antimicrobial active ingredient.

Abstract: Methods of stabilizing color in a composition, which methods comprise: (a) providing an amino-substituted hydroxybenzophenone compound corresponding to the general formula (I): and (b) combining the amino-substituted hydroxybenzophenone compound with a composition to be stabilized selected from the group consisting of cosmetic preparations and dermatological preparations, are described along with compositions containing an organic dye and an amino-substituted hydroxybenzophenone compound corresponding to the general formula (I).

Abstract: The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells, or both, from CD14+ monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD14+ monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14+ monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells. The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models.

Abstract: Methods are disclosed comprising: (a) mixing (i) an aqueous solution of at least one salt of at least one metal selected from the group consisting of aluminum, magnesium, cerium, iron, manganese, cobalt, nickel, titanium, zinc, zirconium and mixtures thereof with (ii) an aqueous solution of at least one polymer, at a pH value of 3 to 13 and at a temperature T1 of 0 to 50° C. to form a mixture; and (b) heating the mixture at a temperature T2 of 60 to 300° C. to form an aqueous suspension of surface-modified nanoparticulate particles comprising at least one compound selected from the group consisting of oxides, hydroxides, and oxide hydroxides of the at least one metal; along with powders prepared therefrom and uses therefore.

Abstract: The present invention relates to surface-modified nanoparticulate metal oxides where the metal is chosen from the group consisting of aluminum, cerium, iron, titanium, zinc and zirconium, wherein the surface modification comprises a coating with a copolymer P comprising, as monomers, A) 1 to 99 mol % of a N-vinylamide N-vinylpyrrolidone and B) 99 to 1 mol % of a monomer comprising, per molecule, a free-radically polymerizable ?,?-ethylenically unsaturated double bond and an anionogenic and/or anionic group, with the proviso that the copolymer P must comprise no further monomers chosen from the group consisting of C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids, N-alkyl- or N,N-dialkyl-substituted amides of acrylic acid or of methacrylic acid with C8-C18-alkyl radicals, or vinyl esters of aliphatic C8-C30-carboxylic acids.

Abstract: The present invention relates to microcapsule dispersions comprising microcapsules in a hydrophobic solvent, wherein the microcapsules have a capsule core, comprising at least one water-soluble organic substance in solution in a hydrophilic solvent, and a capsule shell, obtainable by a) interfacial polyaddition of at least one di-, oligo- and/or polyisocyanate with at least one reagent carrying at least one isocyanate-reactive group and b) subsequent aftertreatment of the primary product microcapsules with at least one compound selected from the group consisting of amines, alcohols and amino alcohols having a molecular weight of at least 150 g/mol and c) if appropriate, subsequent aftertreatment with at least one further aftertreatment reagent.

Abstract: The present invention relates to cosmetic and dermatological preparations for protecting human skin and hair against UV radiation, comprising surface-coated titanium dioxide particles which are transparent in the visible region and have a crystallite size of from 10 to 20 nm and a specific surface area of from 90 to 110 m2/g, wherein the surface coating of the titanium dioxide particles comprises a multicoating of a) aluminum oxide and b) methicone or a copolymer of methicone and dimethicone or a multicoating of a) aluminum oxide, b) methicone or a copolymer of methicone and dimethicone and c) silicon dioxide.