Patents by Inventor Valerie CREPEL

Valerie CREPEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
    Publication number: 20240018524
    Abstract: The present disclosure provides methods and compositions relating to gene therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the present disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuit.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 18, 2024
    Inventors: Valérie CREPEL, Christophe MULLE, Céline BOILEAU, Séverine DEFORGES, Olivier DANOS, Andrew MERCER, Richard PORTER, April R. TEPE
  • COMPOUNDS FOR USE IN THE TREATMENT OF EPILEPSY
    Publication number: 20230323366
    Abstract: The present disclosure relates to gene therapy targeting GluK2 subunit that can be used to inhibit epileptiform discharges. Short interfering RNA sequences against the human Grik2 gene sequence are described which are efficient in decreasing the expression of GluK2-containing KARs in neurons engineered to express the equivalent shRNA or miRNA. Using a tissue culture model of TLE, the examples remarkably demonstrate that viral expression of shRNA or miRNA inhibits the frequency of epileptiform discharges. Therefore, RNA therapeutics aimed at decreasing the expression of GluK2-containing KARs in neurons can remarkably prevent spontaneous epileptiform discharges in TLE. In particular, the present disclosure relates to a recombinant antisense oligonucleotide that targets a Grik2 mRNA.
    Type: Application
    Filed: July 9, 2021
    Publication date: October 12, 2023
    Inventors: Céline BOILEAU, Valérie CREPEL, Séverine DEFORGES, Julie MASANTE, Christophe NULLE, Angélique PERET, Olivier DANOS, Andrew MERCER
  • METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
    Publication number: 20230227829
    Abstract: The present disclosure provides methods and compositions relating to gene therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the present disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuit.
    Type: Application
    Filed: January 13, 2023
    Publication date: July 20, 2023
    Inventors: Valérie CREPEL, Christophe MULLE, Céline BOILEAU, Séverine DEFORGES, Olivier DANOS, Andrew MERCER, Richard PORTER, April R. TEPE
  • METHODS FOR THE TREATMENT OF EPILEPSY
    Publication number: 20230039652
    Abstract: The present disclosure relates to gene therapy targeting GluK2 subunit that can be used to inhibit epileptiform discharges. Short interfering RNA sequences against the human Grik2 gene sequence are described which are efficient in decreasing the expression of GluK2-containing KARs in neurons engineered to express the equivalent shRNA or miRNA. Using a tissue culture model of TLE, the examples remarkably demonstrate that viral expression of shRNA or miRNA inhibits the frequency of epileptiform discharges. Therefore, RNA therapeutics aimed at decreasing the expression of GluK2-containing KARs in neurons can remarkably prevent spontaneous epileptiform discharges in TLE. In particular, the present disclosure relates to a recombinant antisense oligonucleotide that targets a Grik2 mRNA.
    Type: Application
    Filed: June 30, 2022
    Publication date: February 9, 2023
    Inventors: Valérie CREPEL, Christophe Mulle, Céline Boileau, Julie Masante, Séverine Deforges, Angélique Peret, Olivier Danos, Andrew Mercer
  • METHODS FOR THE TREATMENT OF EPILEPSY
    Publication number: 20220251567
    Abstract: The present disclosure relates to gene therapy targeting GluK2 subunit that can be used to inhibit epileptiform discharges. Short interfering RNA sequences against the human Grik2 gene sequence are described which are efficient in decreasing the expression of GluK2-containing KARs in neurons engineered to express the equivalent shRNA or miRNA. Using a tissue culture model of TLE, the examples remarkably demonstrate that viral expression of shRNA or miRNA inhibits the frequency of epileptiform discharges. Therefore, RNA therapeutics aimed at decreasing the expression of GluK2-containing KARs in neurons can remarkably prevent spontaneous epileptiform discharges in TLE. In particular, the present disclosure relates to a recombinant antisense oligonucleotide that targets a Grik2 mRNA.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 11, 2022
    Inventors: Valérie CREPEL, Christophe MULLE, Céline BOILEAU, Julie MASANTE, Séverine DEFORGES, Angélique PERET, Olivier DANOS, Andrew MERCER
  • Method and pharmaceutical composition for use in the treatment of epilepsy
    Patent number: 10016424
    Abstract: The present invention relates to a compound which is an antagonist of the GluK2/GluK5 receptor or an inhibitor of the GluK2/GluK5 receptor expression for use in the treatment or the prevention of epilepsy.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: July 10, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BORDEAUX
    Inventors: Valerie Crepel, Christophe Mulle, Angelique Peret
  • Method and Pharmaceutical Composition for use in the Treatment of Epilepsy
    Publication number: 20160228439
    Abstract: The present invention relates to a compound which is an antagonist of the GluK2/GluK5 receptor or an inhibitor of the GluK2/GluK5 receptor expression for use in the treatment or the prevention of epilepsy.
    Type: Application
    Filed: September 16, 2014
    Publication date: August 11, 2016
    Inventors: Valerie CREPEL, Christophe MULLE, Angelique PERET