Patents by Inventor Valerie De Crecy-Lagard

Valerie De Crecy-Lagard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal of GTP Cyclohydrolase Type IB
    Patent number: 8328934
    Abstract: This invention relates to a novel, bacterial GTP Cyclohydrolase Type IB enzyme, and the crystal structure thereof.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: December 11, 2012
    Assignee: Western University of Health Sciences
    Inventors: Manal A. Swairjo, Dirk Iwata-Reuyl, Valerie de Crecy-Lagard
  • NOVEL GTP CYCLOHYDROLASE TYPE IB
    Publication number: 20100291608
    Abstract: This invention relates to a novel, bacterial GTP Cyclohydrolase Type IB enzyme, and the crystal structure thereof.
    Type: Application
    Filed: April 8, 2010
    Publication date: November 18, 2010
    Applicant: WESTERN UNIVERSITY OF HEALTH SCIENCES
    Inventors: Manal A. SWAIRJO, Dirk IWATA-REUYL, Valerie de CRECY-LAGARD
  • Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases
    Patent number: 7524646
    Abstract: The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: April 28, 2009
    Assignees: Institut Pasteur, The Scripps Research Institute, Evologic GmbH
    Inventors: Volker Doring, Leslie A. Nangle, Tamara L. Hendrickson, Valerie De Crecy-Lagard, Paul Schimmel, Philippe Marliere
  • Enzymatic reduction of a nitrile containing compound to the corresponding amine
    Patent number: 7364882
    Abstract: A new class of enzymes that catalyze the conversion of a nitrile containing compound to the corresponding amine (such as a primary amine) are disclosed. Such enzymes are referred to herein as nitrile oxido-reductases. Methods of using the enzymes to reduce a nitrile to a amine, for example in vitro or in vivo, are provided. Such methods provide the first biocatalysis method for reducing nitrites to amines, and provides an alternative to currently used methods, which generally utilize harsh reaction conditions and the production of hazardous waste. While the hydrolysis of nitrites to amides and carboxylic acids via biocatalysis has found extensive use in industry, the lack of a known nitrile oxido-reductase has precluded the application of biocatalysis to nitrile reduction.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: April 29, 2008
    Assignees: State of Oregon Acting by and Through the State Board of Higher Education on Behalf of Portland State University, Scripps Research Institute
    Inventors: Dirk Iwata-Reuyl, Valérie de Crecy-Lagard, Steven G. Van Lanen
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 7090999
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: August 15, 2006
    Assignee: sanofi-aventis
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Publication number: 20040229236
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Application
    Filed: November 20, 2003
    Publication date: November 18, 2004
    Applicant: Aventis Pharma
    Inventors: Veronique Blanc, Francis Blanche, Joerl Crouzet, Nathalie Jacoues, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6670157
    Abstract: The invention concerns methods for preparing pristinamycin IIB and methods for preparing modified pristinamycin IIB.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: December 30, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases
    Publication number: 20030148422
    Abstract: The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.
    Type: Application
    Filed: April 19, 2002
    Publication date: August 7, 2003
    Inventors: Volker Doring, Leslie A. Nangle, Tamara L. Hendrickson, Valerie de Crecy-Lagard, Paul Schimmel, Philippe Marliere
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6171846
    Abstract: The invention concerns mutant microorganisms blocked in a step of Streptogramin biosynthesis and methods for preparing cells blocked in a step of Streptogramin biosynthesis.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia LaCroix, Denis Thibaut, Monique Zagorec, Laurent DeBussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6077699
    Abstract: Disclosed is the nucleic acid sequences for polypeptides and enzymes involved in the biosynthesis of streptogramins from Streptomyces sp. and the corresponding amino acid sequences. Also disclosed are recombinant vectors and cells as well as methods of making the polypeptides, enzymes and streptogramins using the recombinant host cells.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: June 20, 2000
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 5891695
    Abstract: The invention concerns nucleotide sequences coding for a polypeptide involved in Streptogramin biosynthesis, recombinant cells containing said sequences, and use thereof.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: April 6, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard