Patents by Inventor Valerie Duval

Valerie Duval has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
    Patent number: 11931409
    Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: March 19, 2024
    Assignee: Combined Therapeutics, Inc.
    Inventors: Romain Micol, Valerie Duval
  • COMPOSITIONS AND METHODS FOR IMPROVED VACCINATION
    Publication number: 20240024451
    Abstract: Provided is a composition comprising a first mRNA construct comprising a first open reading frame (ORF), wherein the first ORF encodes an antigen; wherein the first ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least a first organ protection sequence (OPS), and wherein the first OPS comprises at least two micro-RNA (miRNA) target sequences, wherein each of the at least two miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. Also provided are further compositions comprising mRNA constructs comprising an ORF and an OPS wherein the ORF encodes a proinflammatory cytokine, and methods including one or both of these compositions for the treatment and prevention of disease such as pathogenic disease.
    Type: Application
    Filed: July 30, 2021
    Publication date: January 25, 2024
    Inventors: Romain Micol, Valerie Duval
  • COMPOSITIONS AND METHODS FOR ORGAN-PROTECTIVE EXPRESSION AND MODULATION OF CODING RIBONUCLEIC ACIDS
    Publication number: 20230241206
    Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.
    Type: Application
    Filed: February 10, 2023
    Publication date: August 3, 2023
    Inventors: Romain Micol, Valerie Duval
  • Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
    Patent number: 11596685
    Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: March 7, 2023
    Assignee: Combined Therapeutics, Inc.
    Inventors: Romain Micol, Valerie Duval
  • COMPOSITIONS AND METHODS FOR ORGAN-PROTECTIVE EXPRESSION AND MODULATION OF CODING RIBONUCLEIC ACIDS
    Publication number: 20220202932
    Abstract: Compositions are provided comprising messenger RNA constructs having at least one open reading frame (ORF), wherein the ORF is operatively linked to at least one untranslated region (UTR), wherein the UTR comprises at least one organ protection sequence (OPS), wherein the OPS sequence comprises at least a first, a second and a third micro-RNA (miRNA) target sequence, and wherein each of the at least a first, second and third the miRNA target sequences are optimised to hybridise with a corresponding miRNA sequence. The compositions and molecules provided are useful in therapies such as for the treatment of cancer, in immunotherapies, and in vaccines.
    Type: Application
    Filed: March 8, 2022
    Publication date: June 30, 2022
    Inventors: Romain Micol, Valerie Duval