Abstract: An immunogen comprising a residue of a histamine-releasing peptide comprising a cationic N-terminal head and a hydrophobic C-terminal tail, together with a residue capable of eliciting antibodies against said peptide whilst inhibiting histamine release by said peptide is useful in anti-allergy treatment. Preferably the histamine-releasing peptide is of formula:Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe,optionally amidated at the C terminal.Antibodies to the histamine-releasing peptide are useful for passive immunisation.

Abstract: An immunogen comprising a residue of a histamine-releasing peptide comprising a cationic N-terminal head and a hydrophobic C-terminal tail, together with a residue capable of eliciting antibodies against said peptide while inhibiting histamine release by said peptide is useful in anti-allergy treatment. Preferably the histamine-releasing peptide is of formula:Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe, SEQ ID NO: 6optionally amidated at the C terminal.Antibodies to the histamine-releasing peptide are useful for passive immunization.

Abstract: A trailer for towing by family saloon cars and the like has a wheeled frame (12) with a towing hitch (34) at the front. The frame has a respective ramp rail (22) at each side to enable a skip (14) to be drawn onto the frame, a support wheel (25) of the skip engaging on each rail. The skip can carry heavy bulk loads such as sand or bricks in the region of a ton which normal car trailers could not support. In addition, the mounting of the skip on the trailer frame by means of support wheels enables the skip to be pivoted in situ to tip out its load. Tipping, and mounting and demounting of the skip are effected using winch (16) supported on the frame near the towing hitch. The trailer also has a pivotable ramp (50) enabling the trailer to be used to carry heavy plant such as a cement mixer or roller.