Patents by Inventor Valerie Lallemand-Breitenbach

Valerie Lallemand-Breitenbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT PATIENTS SUFFERING FROM MYELOPROLIFERATIVE DISORDERS
    Publication number: 20190374611
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of myeloproliferative disorders in patients presenting a dysregulation of the JAK2-STAT signalling pathway. Using MPN mouse model and clonogenic methyl-cellulose cultures of patient progenitors, the inventors demonstrate that combining ARS with IFN improves most of the benefits provided by IFN alone during MPN treatment. In particular, the present invention relates to a method of treating a myeloproliferative disorder in a patient presenting a dysregulation of the JAK2-STAT signalling pathway comprising administering to the patient a therapeutically effective combination of an interferon polypeptide and an arsenic compound.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 12, 2019
    Inventors: Hugues DE THE, Bruno CASSINAT, Valérie LALLEMAND-BREITENBACH, Isabelle PLO, Jean-Luc VILLEVAL, Jean-Jacques KILADJIAN
  • Drug monitoring methods using the promyelocytic leukemia protein as a redox sensor
    Patent number: 9228998
    Abstract: The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of PML nuclear bodies in said cell or tissue.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: January 5, 2016
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DIDEROT—PARIS 7
    Inventors: Hugues De The, Valerie Lallemand-Breitenbach
  • Promyelocytic Leukemia Protein as a Redox Sensor
    Publication number: 20140205568
    Abstract: The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of PML nuclear bodies in said cell or tissue.
    Type: Application
    Filed: March 7, 2014
    Publication date: July 24, 2014
    Applicant: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Hugues De The, Valerie Lallemand-Breitenbach
  • Promyelocytic leukemia protein as a redox sensor
    Patent number: 8735171
    Abstract: The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of PML nuclear bodies in said cell or tissue.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: May 27, 2014
    Assignee: Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Hugues De The, Valerie Lallemand-Breitenbach
  • PROMYELOCYTIC LEUKEMIA PROTEIN AS A REDOX SENSOR
    Publication number: 20130028863
    Abstract: The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of PML nuclear bodies in said cell or tissue.
    Type: Application
    Filed: January 13, 2011
    Publication date: January 31, 2013
    Inventors: Hugues De The, Valerie Lallemand-Breitenbach