Abstract: Generation of an executable file derived from a parent executable file having ranges of physical addresses referencing a binary code of at least one core feature (CR), a binary code of a set of native features (F), bytecodes of a set of java features (Pkg), by selecting at least one native feature from the set of native features to be removed, defining the range of physical addresses where the binary code of the selected native feature is stored, selecting at least one java feature from the set of java features to be relocated, and relocating the bytecodes of said at least one selected java feature in the defined range of physical addresses.

Abstract: Coffee compositions that are derived from medium- and high-yield extracts while also having improved taste and aroma. Processes for producing such coffee compositions are also disclosed.

Abstract: Generation of an executable file derived from a parent executable file having ranges of physical addresses referencing a binary code of at least one core feature (CR), a binary code of a set of native features (F), bytecodes of a set of java features (Pkg), by selecting at least one native feature from the set of native features to be removed, defining the range of physical addresses where the binary code of the selected native feature is stored, selecting at least one java feature from the set of java features to be relocated, and relocating the bytecodes of said at least one selected java feature in the defined range of physical addresses.

Abstract: A directional radiation detection system and an omnidirectional radiation detector. The omnidirectional radiation detector detects radiation comprising at least one of: (i) gamma rays; and (ii) neutron particles. A radiation scatter mask (RSM) of the radiation detection system includes a rotating sleeve received over the omnidirectional radiation detector and rotating about a longitudinal axis. The RSM further includes: (i) a fin extending longitudinally from one side of the rotating sleeve; and (ii) a wall extending from the rotating sleeve and spaced apart from the fin having an upper end distally positioned on the rotating sleeve spaced apart or next to from a first lateral side of the fin and a lower end proximally positioned on the rotating sleeve and spaced apart from or next to a second lateral side of the fin.

Abstract: A directional radiation detection system and an omnidirectional radiation detector. The omnidirectional radiation detector detects radiation comprising at least one of: (i) gamma rays; and (ii) neutron particles. A radiation scatter mask (RSM) of the radiation detection system includes a rotating sleeve received over the omnidirectional radiation detector and rotating about a longitudinal axis. The RSM further includes: (i) a fin extending longitudinally from one side of the rotating sleeve; and (ii) a wall extending from the rotating sleeve and spaced apart from the fin having an upper end distally positioned on the rotating sleeve spaced apart or next to from a first lateral side of the fin and a lower end proximally positioned on the rotating sleeve and spaced apart from or next to a second lateral side of the fin.

Abstract: The invention related to pyrazolonaphthyridinone derivatives of formula (I) to their preparation and to their therapeutic use as selective inhibitors of type 2 methionine aminopeptidase (hMETAP2).

Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.

Abstract: The invention related to pyrazolonaphthyridinone derivatives of formula (I) to their preparation and to their therapeutic use as selective inhibitors of type 2 methionine aminopeptidase (hMETAP2).

Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.

Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.

Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.

Abstract: The present invention relates to derivatives of pyridino-pyridinones, and to their preparation and use thereof, having activity as inhibitors of kinase activity of receptors for PDGF (platelet derived growth factors) ligands and optionally of receptors for the FLT3 (fms-like tyrosine kinase receptor) ligand receptors, said derivatives comprising compounds of formula (I): wherein the various substituent groups are more specifically defined herein. The compounds are suitable as therapeutics for the treatment of various proliferative diseases.

Abstract: The present invention relates to pyridopyridone derivatives of formula (I): in which the variables are as defined herein, to their preparation and to their therapeutic use as inhibitors of the kinase activity of PDGF (platelet-derived growth factor) ligand receptors and possibly of FLT3 (fms-like tyrosine kinase receptor) ligand receptors.

Abstract: The present invention relates to derivatives of pyridino-pyridinones, and to their preparation and use thereof, having activity as inhibitors of kinase activity of receptors for PDGF (platelet derived growth factors) ligands and optionally of receptors for the FLT3 (fms-like tyrosine kinase receptor) ligand receptors, said derivatives comprising compounds of formula (I): wherein the various substituent groups are more specifically defined herein. The compounds are suitable as therapeutics for the treatment of various proliferative diseases.

Abstract: The present invention relates to pyridopyridone derivatives of formula (I): in which the variables are as defined herein, to their preparation and to their therapeutic use as inhibitors of the kinase activity of PDGF (platelet-derived growth factor) ligand receptors and possibly of FLT3 (fms-like tyrosine kinase receptor) ligand receptors.

Abstract: The invention concerns compounds of formula (I) in which: R is —NO2 or —NHR3, R3 being hydrogen, —COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, —COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), —CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), —SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a —CH2—, —SO2 or —NR1— group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.