Abstract: This disclosure concerns expandable devices, specifically self-deployed devices, for adherence to a tissue, for example intestinal tissue. The disclosure also concerns expandable devices, specifically self-deployed devices for delivery of at least one active agent to, or across, a tissue.

Abstract: The disclosure provides a biodegradable device, administered to a patient in a compact ingestible encapsulated form. The device is self-expandable in the stomach upon contact with liquid, to assume an expanded, voluminous configuration within the stomach. The devices have a folded configuration in which intake is facilitated by the patient, and are designed to unfold and self-expand in the stomach after intake due to expansion of a plurality of expandable zones that comprise one or more gel-forming materials. The disclosure provides such devices, methods of their manufacture, as well as base units thereof.