Patents by Inventor Valery Zavenovich Akhverdian

Valery Zavenovich Akhverdian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing a lower alkyl ester of ?-L-aspartyl-L-phenylalanine using bacteria
    Patent number: 7531332
    Abstract: A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing the activity of the protein encoded by the yedA gene. A further method is provided for producing a lower alkyl ester of ?-L-aspartyl-L-phenylalanine by producing L-phenylalanine by cultivating an Escherichia coli bacterium in a medium, wherein said bacterium has the ability to produce L-phenylalanine, and synthesizing the lower alkyl ester of ?-L-aspartyl-L-phenylalanine from aspartic acid, or a derivative thereof, and the produced L-phenylalanine.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: May 12, 2009
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Maria Viacheslavovna Vitushkina, Mikhail Markovich Gusyatiner, Mikhail Kharisovich Ziyatdinov, Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Vera Georgievna Doroshenko, Sergey Vladimirovich Mashko
  • Method for Producing L-Amino Acids Using Escherichia Bacteria
    Publication number: 20080153138
    Abstract: A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing the activity of the protein encoded by the yedA gene. A further method is provided for producing a lower alkyl ester of ?-L-aspartyl-L-phenylalanine by producing L-phenylalanine by cultivating an Escherichia coli bacterium in a medium, wherein said bacterium has the ability to produce L-phenylalanine, and synthesizing the lower alkyl ester of ?-L-aspartyl-L-phenylalanine from aspartic acid, or a derivative thereof, and the produced L-phenylalanine.
    Type: Application
    Filed: June 12, 2007
    Publication date: June 26, 2008
    Inventors: Vitaliy Arkadyevich Livshits, Maria Viacheslavovna Vitushkina, Mikhail Markovich Gusyatiner, Mikhail Kharisovich Ziyatdinov, Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Vera Georgievna Doroshenko, Sergey Vladimirovich Mashko
  • bacteria transformed with a yedA homolog to enhance L-amino acid producing activity, and methods for producing an L-amino acid using same
    Patent number: 7259003
    Abstract: A method for producing an L-amino acid, such as L-phenylalanine or L-threonine, is provided using a bacterium belonging to the genus Escherichia, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the protein encoded by the yedA gene.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: August 21, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Maria Viacheslavovna Vitushkina, Mikhail Markovich Gusyatiner, Mikhail Kharisovich Ziyatdinov, Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Vera Georgievna Doroshenko, Sergey Vladimirovich Mashko
  • L-threonine producing bacterium belonging to the genus and method for producing L-threonine
    Patent number: 7186531
    Abstract: There is disclosed a method for producing L-threonine using bacterium belonging to the genus Escherichia wherein the bacterium has been modified to enhance an activity of aspartate-?-semialdehyde dehydrogenase.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: March 6, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Alla Markovna Kaplan, Andrey Olegovich Lobanov, Yuri Ivanovich Kozlov
  • Method of producing amino acids using transformed with sucrose PTS genes
    Patent number: 7179623
    Abstract: Amino acids such as threonine, homoserine, isoleucine, lysine, valine and tryptophan are produced using a bacterium belonging to the genus Escherichia which has been constructed from a sucrose non-assimilative strain belonging to the genus Escherichia and which harbors sucrose non-PTS or PTS genes and has an ability to produce the amino acid.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: February 20, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Sergei Vladimirovich Mashko, Valery Zavenovich Akhverdian, Yury Ivanovich Kozlov
  • Methods of making amino acids using E. coli transformed with csc genes
    Patent number: 6960455
    Abstract: An amino acid such as threonine, homoserine, isoleucine, lysine, valine and tryptophan is produced using a bacterium belonging to the genus Escherichia which has been constructed from sucorse non-assimilative strain belonging to the genus Escherichia and which harbors sucrose non-PTS (phosphoenol pyruvate-dependent sucrose-6-phosphotransferase system) genes and has an ability to produce the amino acid.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: November 1, 2005
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Sergei Vlsdimirovich Mashko, Valery Zavenovich Akhverdian, Yury Ivanovich Kozlov
  • Method for producing L-threonine using bacteria belonging to the genus Escherichia
    Publication number: 20040132165
    Abstract: There is disclosed a method for producing L-threonine using bacterium belonging to the genus Escherichia wherein the bacterium has L-theonine productivity and has been modified to enhance an activity of aspartate aminotransferase.
    Type: Application
    Filed: September 30, 2003
    Publication date: July 8, 2004
    Inventors: Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Alla Markovna Kaplan, Andrey Olegovich Lobanov, Yuri Ivanovich Kozlov
  • Mutant ilvH gene and method for producing L-valine
    Patent number: 6737255
    Abstract: The present invention provides an isolated DNA molecule encoding a small subunit of acetohydroxy acid synthase isozyme III originating from Escherichia coli and mutants of Escherichia coli acetohydroxy acid synthase isozyme III, which are free from inhibition by L-valine an can catalyze the conversion of: (a) pyruvate to &agr;-acetolactate and (b) &agr;-ketobutyrate and pyruvate to &agr;-aceto-a-hydroxybutyrate. The present invention also provides methods for producing L-valine by fermentation of a bacterium harboring the novel DNA molecule and/or expressing the mutant acetohydroxy acid synthase isozyme III.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: May 18, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Nataliya Vasilyevna Gorshkova, Alla Valentinovna Belaryeva, Lirina Valeryevna Ivanovskaya, Evgeni Moiseevich Khourges, Valery Zavenovich Akhverdian, Mikhail Markovich Gusyatiner, Yury Ivanovich Kozlov
  • Method for producing L-amino acid using bacteria belonging to the genus escherichia
    Publication number: 20030148473
    Abstract: A method for producing an L-amino acid, such as L-phenylalanine, L-threonine is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yedA gene.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Maria Viacheslavovna Vitushkina, Mikhail Markovich Gusyatiner, Mikhail Kharisovich Ziyatdinov, Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Vera Georgievna Doroshenko, Sergey Vladimirovich Mashko
  • Mutant ilvH gene and method for producing L-valine
    Publication number: 20020037562
    Abstract: A method for producing L-valine comprising the steps of cultivating the bacterium harboring a DNA coding for actohydroxy acid synthase isozime III originating from Escherichia coli which is free from a inhibition by L-valine and has an activity to catalyze two reactions to generate &agr;-acetolactate from pyruvate and &agr;-aceto-&agr;-hydroxybutyrate from &agr;-ketobutyrate and pyruvate, producing and accumulating L-valine in the culture medium, and collecting L-valine from the culture medium.
    Type: Application
    Filed: January 18, 2001
    Publication date: March 28, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Nataliya Vasilyevna Gorshkova, Alla Valentinovna Belaryeva, Lirina Valeryevna Ivanovskaya, Evgeni Moiseevich Khourges, Valery Zavenovich Akhverdian, Mikhail Markovich Gusyatiner, Yury Ivanovich Kozlov
  • Amino acid producing strains belonging to the genus Escherichia and method for producing amino acid
    Publication number: 20010049126
    Abstract: An amino acid such as threonine, homoserine, isoleucine, lysine, valine and tryptophan is produced using a bacterium belonging to the genus Escherichia which has been constructed from a sucorse non-assimilative strain belonging to the genus Escherichia and which harbors sucrose non-PTS or PTS genes and has an ability to produce the amino acid.
    Type: Application
    Filed: April 25, 2001
    Publication date: December 6, 2001
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Sergei Vlsdimirovich Mashko, Valery Zavenovich Akhverdian, Yury Ivanovich Kozlov