Patents by Inventor Valina L. Dawson

Valina L. Dawson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunophilin-binding agents prevent glutamate neurotoxicity associated with vascular stroke and neurodegenerative diseases
    Patent number: 6362160
    Abstract: Immunophilin-binding agents inhibit the phosphatase calcineurin, leading to the increased phosphorylation of certain brain proteins, including nitric oxide synthase. The increased levels of phosphorylation of nitric oxide synthase inhibits the enzymatic production of nitric oxide. Thus the neurotoxic effects of glutamate, which are ordinarily the result of vascular strokes and other neurodegenerative diseases, are minimized, because the neurotoxic effects are at least partially mediated by nitric oxide. Thus immunophilin-binding drugs can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease and Huntington's disease.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: March 26, 2002
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Ted M. Dawson, Joseph P. Steiner, Valina L. Dawson, George R. Uhl, Solomon H. Snyder
  • Method of using selective parp inhibitors to prevent or treat neurotoxicity
    Patent number: 6358975
    Abstract: Neutral tissue damage resulting for ischemia and reperfusion injury or neurodegenerative diseases can be prevented by administering therapeutically effective amounts of certain selective inhibitors of poly(ADP-ribose)polymerase. The inhibitors can be administered intravenously, intraperitoneally, intramuscularly, intraventricularly, or orally. They can be administered as a capsule or tablet containing single or divided dose. Alternatively, the inhibitors can be administered as a sterile solution, suspension or emulsion.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: March 19, 2002
    Assignee: Johns Hopkins University
    Inventors: Mikael J. Eliasson, Kenji Sampei, Allen S. Mandir, Patricia D. Hurn, Richard J. Traystman, Jun Bao, Andrew Pieper, Ted M. Dawson, Solomon Snyder, Valina L. Dawson
  • Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
    Patent number: 5587384
    Abstract: Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: December 24, 1996
    Assignees: The Johns Hopkins University, The United States of America
    Inventors: Jie Zhang, Valina L. Dawson, Ted M. Dawson, Solomon H. Snyder
  • Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity
    Patent number: 5266594
    Abstract: Inhibitors of nitric acid synthase can be used to prevent neurotoxicity mediated through glutamate receptors. Nitric oxide synthase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease and Huntington's disease.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: November 30, 1993
    Inventors: Valina L. Dawson, Ted M. Dawson, Edythe D. London, David S. Bredt, Solomon H. Snyder
  • Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
    Patent number: RE36397
    Abstract: Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: November 16, 1999
    Assignees: The John Hopkins University, The United States of America
    Inventors: Jie Zhang, Valina L. Dawson, Ted M. Dawson, Solomon H. Snyder