Patents by Inventor Valter D. Longo

Valter D. Longo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210137149
    Abstract: A fasting mimicking diet package providing daily meal portions for a predetermined number of days is provided. The fasting mimicking diet package includes a kale cracker composition, a first vegetable broth composition, a mushroom soup composition, a tomato soup composition, a quinoa-containing minestrone soup composition, a bean-containing minestrone soup composition, and a pumpkin soup composition. Characteristically, the daily meal portions are packaged into meal servings or into a total daily serving to be divided into meals.
    Type: Application
    Filed: September 1, 2020
    Publication date: May 13, 2021
    Inventors: Sebastian BRANDHORST, Valter D. LONGO, Min WEI
  • Publication number: 20210137856
    Abstract: A method for treating a hyperglycemia and hyperglycemia-dependent side effects in a subject undergoing chemotherapy includes a step of identifying a subject undergoing chemotherapy and being administered a hyperglycemia-inducing agent. Short-term starvation or a fasting mimicking diet is administered for a first time period to the subject to prevent hyperglycemia and sensitization to chemotherapy associated with increased glucose levels. The STS-mimicking drug Metformin is administrated between STS/FMD cycles to maintain STS/FMD-like conditions during the re-feeding period.
    Type: Application
    Filed: January 12, 2021
    Publication date: May 13, 2021
    Inventors: VALTER D. LONGO, STEFANO DI BIASE
  • Patent number: 11000057
    Abstract: Methods for lowering hypertension, elevated total cholesterol, elevated glucose and insulin, elevated IGF-1, elevated triglyceride levels, and/or elevated CRP levels, and elevated liver fat without negatively affecting or lowering the levels of these markers/factors in subjects with already low levels of these markers are provided. A method for elevating stem cells and regeneration and anti-inflammatory agents is also provided. Finally, a method for treating metabolic syndrome is also provided. A hypocaloric or calorie free diet or a fasting mimicking diet is administered for a first time period to the subject to reduce blood pressure or the levels of the above markers/risk factors for aging and age-related diseases.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: May 11, 2021
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Sebastian Brandhorst, Min Wei
  • Patent number: 10932486
    Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 2, 2021
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Chia-Wei Cheng
  • Publication number: 20200390833
    Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.
    Type: Application
    Filed: March 15, 2019
    Publication date: December 17, 2020
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. LONGO, Min WEI, Priya RANGAN
  • Publication number: 20200345053
    Abstract: A method of treating Alzheimer's associated pathology includes a step of identifying subject having a pathology that is associated with Alzheimer's disease. A fasting mimicking diet (FMD) is then administered to the subject for a first time period. Methods for treating amyloid plaque formation and/or elevated levels of tau protein as well as neuroinflammation are also provided.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Valter D. LONGO, Min WEI, Priya RANGAN
  • Patent number: 10660932
    Abstract: Stem cell-based therapies can potentially reverse organ dysfunction and diseases but the removal of impaired tissue and reactivation of the program leading to organ regeneration pose major challenges. In mice, a four-day fasting mimicking diet (FMD) induces a step-wise expression of Sox17 and Pdx-1, resembling that observed during pancreatic development and followed by Ngn3-driven generation of insulin-producing ?-cells. FMD cycles restore insulin secretion and glucose homeostasis in both a type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: May 26, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Roberta Buono
  • Publication number: 20200146320
    Abstract: A nutrition bar to be used for an intermittent fasting-mimicking meal includes any combination of macadamia nuts; honey; pecans; almonds; almond butter; coconut; inulin; flax seeds; coconut oil; cocoa derivatives; and coconut flour. Characteristically, the nutrition bar of 40% or more fat provides from 100 to 300 kcal of which 40 percent kcal are from fats and 10 to 30 percent kcal are from carbohydrates with less than 10 grams of protein.
    Type: Application
    Filed: November 12, 2019
    Publication date: May 14, 2020
    Inventor: Valter D. LONGO
  • Publication number: 20200029614
    Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
    Type: Application
    Filed: October 3, 2019
    Publication date: January 30, 2020
    Inventors: Valter D. LONGO, Chia-Wei Cheng
  • Patent number: 10433576
    Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: October 8, 2019
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Chia-Wei Cheng
  • Publication number: 20190285640
    Abstract: A microarray is provided to be used in a method for determining risk of developing age-related disease in a subject. The microarray provides expression patterns for a control group and a subject to access the risk of developing age-related disease. The microarray including nucleic acid probes that hybridize to genes encoding IGF-I, IGFBP1, GH, insulin, GHR, RAS, AKT, TOR, S6K, SOD2, and FOXO.
    Type: Application
    Filed: February 4, 2019
    Publication date: September 19, 2019
    Inventor: Valter D. Longo
  • Publication number: 20190276445
    Abstract: Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.
    Type: Application
    Filed: March 27, 2019
    Publication date: September 12, 2019
    Inventors: Valter D. LONGO, Priya BALASUBRAMANIAN, Nouri NEAMATI, Min WEI
  • Patent number: 10246446
    Abstract: Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: April 2, 2019
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Priya Balasubramanian, Nouri Neamati, Min Wei
  • Publication number: 20190029301
    Abstract: A method for treating a subject with multiple myeloma includes a step of identifying a patient having multiple myeloma. A fasting mimicking and enhancing diet is administered to the subject for a predetermined time period of at least 8 days. A diet package for implementing the method is also provided.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 31, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. LONGO, Woodring E. WRIGHT
  • Patent number: 10172839
    Abstract: A method of alleviating or treating symptoms of cancer and/or effects of chemotherapy or of kinase inhibitors includes a step of identifying a subject having cancer. A reduced caloric diet is administered to the subject for a first time period, the reduced caloric diet providing at most 1000 kcal per day. A kinase inhibitor is administered to the subject.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 8, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Stefano Di Biase
  • Publication number: 20180228198
    Abstract: A fasting mimicking diet package providing daily meal portions for a predetermined number of days is provided. The fasting mimicking diet package includes a kale cracker composition, a first vegetable broth composition, a mushroom soup composition, a tomato soup composition, a quinoa-containing minestrone soup composition, a bean-containing minestrone soup composition, and a pumpkin soup composition. Characteristically, the daily meal portions are packaged into meal servings or into a total daily serving to be divided into meals.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 16, 2018
    Inventors: SEBASTIAN BRANDHORST, VALTER D. LONGO, MIN WEI
  • Patent number: 10015980
    Abstract: A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: July 10, 2018
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Valter D. Longo, Chia-Wei Cheng, Sebastian Brandhorst, Min Wei
  • Publication number: 20170342063
    Abstract: Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.
    Type: Application
    Filed: February 12, 2016
    Publication date: November 30, 2017
    Inventors: Valter D. LONGO, Priya BALASUBRAMANIAN, Nouri NEAMATI, Min WEI
  • Publication number: 20170325493
    Abstract: A method for treating autoimmune and/or inflammatory diseases includes a step of identifying a subject having a gastrointestinal autoimmune/inflammatory disease. A fasting mimicking diet (FMD) is administered to the subject for a first time period.
    Type: Application
    Filed: May 11, 2017
    Publication date: November 16, 2017
    Inventors: VALTER D. LONGO, IN YOUNG CHOI
  • Publication number: 20170232053
    Abstract: Stem cell-based therapies can potentially reverse organ dysfunction and diseases but the removal of impaired tissue and reactivation of the program leading to organ regeneration pose major challenges. In mice, a four-day fasting mimicking diet (FMD) induces a step-wise expression of Sox17 and Pdx-1, resembling that observed during pancreatic development and followed by Ngn3-driven generation of insulin-producing ?-cells. FMD cycles restore insulin secretion and glucose homeostasis in both a type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models.
    Type: Application
    Filed: February 15, 2017
    Publication date: August 17, 2017
    Inventors: VALTER D. LONGO, ROBERTA BUONO