Patents by Inventor Vamsee Pamula
Vamsee Pamula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965874Abstract: A sample processing unit (SPU)-equipped drone for transporting and processing biological materials and method of using same is disclosed. In some embodiments, the presently disclosed SPU-equipped drone and method provide a drone equipped to carry an SPU and wherein the SPU may include a centrifuge arranged inside a temperature-controlled chamber and wherein the centrifuge may be used to process biological materials at the same time that the SPU-equipped drone is in flight. Further, a method of using the presently disclosed SPU-equipped drone for transporting and processing biological materials is provided.Type: GrantFiled: December 7, 2020Date of Patent: April 23, 2024Inventors: Ganapathi Pamula, Lakshmi Pamula, Jia Mathur, Vamsee Pamula
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Publication number: 20240109071Abstract: A method of thermal cycling a droplet, including providing a droplet actuator with heaters establishing a first thermal zone and second thermal zone in a substantially oil-filled droplet operations gap; a thermal cycling path comprising droplet operations electrodes comprising a first droplet operations electrode in the first thermal zone and a second droplet operations electrode in the second thermal zone, wherein the first and second droplet operations electrodes are within 5 mm of each other; a first temperature at the first droplet operations electrode and a second temperature at the second droplet operations electrode, wherein the first and second temperatures differ by at least about 10° C.; and using the droplet operations electrodes, transporting the droplet in a cycling pattern for multiple cycles along the thermal cycling path between the first droplet operations electrode and the second droplet operations electrode. Cartridges and systems are also provided.Type: ApplicationFiled: December 1, 2023Publication date: April 4, 2024Applicant: Baebies, Inc.Inventors: Daniel Wu, Rainer Ng, Greg Smith, Vijay Srinivasan, Vamsee Pamula
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Publication number: 20230331405Abstract: According to some embodiments, a freezer-equipped drone for transporting biological materials and method of using same is provided. In some embodiments, a freezer-equipped drone comprises a temperature control device for transporting biological materials, such as, but not limited to, vaccines, blood samples, urine samples, saliva samples, nasal samples, bodily fluids, tissue samples, and the like. For example, a freezer-equipped drone can comprise a drone equipped with a mini freezer for holding biological materials that may be activated to some desired temperature using active cooling mechanisms at the same time of aerial transport.Type: ApplicationFiled: June 22, 2023Publication date: October 19, 2023Inventors: Ganapathi Pamula, Lakshmi Pamula, Vamsee Pamula
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Publication number: 20230304066Abstract: A method for assaying analytes in a blood sample by loading a blood sample onto a microfluidic device; combining the blood sample with a buffer reagent comprising a surfactant to provide a diluted blood sample and conduct an assay. The surfactant is selected to permit the use of electrowetting to conduct droplet operations using the blood sample and to permit the use of a fluorescence-based droplet operation. The assay may be an unbound bilirubin assay.Type: ApplicationFiled: September 7, 2021Publication date: September 28, 2023Applicant: Baebies, Inc.Inventors: Michael A. BASMAJIAN, Jennifer ELDERBROOM, Maithri KRISHNAMURTHY, Erik BURDE, Michael BOSO, Daniel Hull, Rainer NG, Vijay SRINIVASAN, Ramakrishna SISTA, Vamsee PAMULA
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Publication number: 20230116264Abstract: Coagulation assays for a point-of-care platform is disclosed. For example, the disclosure provides methods of measuring viscoelastic properties in a droplet on a microfluidics device, including using electrowetting-mediated droplet operations on the microfluidics device. In some embodiments, a microfluidics point-of-care platform may be used for assaying and/or monitoring coagulation of a blood sample. The disclosure provides a system, digital microfluidics device, and methods for measuring coagulation of a blood sample. In various embodiments, the disclosure provides a microfluidics device including droplets subject to manipulation by the device wherein droplet movement is used to characterize coagulation of a blood sample.Type: ApplicationFiled: October 10, 2022Publication date: April 13, 2023Applicant: Baebies, Inc.Inventors: Michael A. Basmajian, Michael Boso, Vijay SRINIVASAN, Vamsee PAMULA
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Publication number: 20220412067Abstract: Power generation devices and methods for use with toilets is disclosed. A number of power generation devices are provided that can be used in combination to power various features in a toilet which will be particularly useful for portable toilets that are off the grid. The power generation devices and methods include, for example, using a cell battery inside a toilet water source, a wind turbine, solar panels, and piezoelectricity. The features include, for example, lighting up the toilet with light-emitting diodes (LEDs) to make it easier for users to find the toilet, an audio/video setup for entertainment, and a toilet status light indicator to let the next user know when the toilet paper is out.Type: ApplicationFiled: August 24, 2022Publication date: December 29, 2022Inventors: Ganapathi Pamula, Shubham Mathur, Snehil Mathur, Vamsee Pamula
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Publication number: 20210311042Abstract: A point-of birth system and instrument, biochemical cartridge, and methods for newborn screening is disclosed. Namely, a point-of-birth system is provided the includes a point-of-birth instrument for receiving and processing a biochemical cartridge for performing newborn screening. Further, a portable smart device, such as a smartphone or tablet, is in communication with point-of birth instrument, wherein the smart device may include a newborn screening (NBS) mobile app. In one example, the point-of-birth system and point-of-birth instrument support newborn biological screening only. However, in another example, the point-of-birth system and point-of birth instrument support both newborn biological screening and newborn physiological screening.Type: ApplicationFiled: June 15, 2021Publication date: October 7, 2021Applicant: Baebies, Inc.Inventors: Vamsee Pamula, Vijay Srinivasan, Donovan Bort
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Patent number: 11035855Abstract: A point-of-birth system and instrument, biochemical cartridge, and methods for newborn screening is disclosed. Namely, a point-of-birth system is provided that includes a point-of-birth instrument for receiving and processing a biochemical cartridge for performing newborn screening. Further, a portable smart device, such as a smartphone or tablet, is in communication with point-of-birth instrument, wherein the smart device may include a newborn screening (NBS) mobile app. In one example, the point-of-birth system and point-of-birth instrument support newborn biological screening only. However, in another example, the point-of-birth system and point-of-birth instrument support both newborn biological screening and newborn physiological screening.Type: GrantFiled: May 1, 2017Date of Patent: June 15, 2021Assignee: Baebies, Inc.Inventors: Vamsee Pamula, Vijay Srinivasan, Donovan Bort
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Publication number: 20210172930Abstract: A sample processing unit (SPU)-equipped drone for transporting and processing biological materials and method of using same is disclosed. In some embodiments, the presently disclosed SPU-equipped drone and method provide a drone equipped to carry an SPU and wherein the SPU may include a centrifuge arranged inside a temperature-controlled chamber and wherein the centrifuge may be used to process biological materials at the same time that the SPU-equipped drone is in flight. Further, a method of using the presently disclosed SPU-equipped drone for transporting and processing biological materials is provided.Type: ApplicationFiled: December 7, 2020Publication date: June 10, 2021Inventors: Ganapathi Pamula, Lakshmi Pamula, Jia Mathur, Vamsee Pamula
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Publication number: 20200149260Abstract: Power generation devices and methods for use with toilets is disclosed. A number of power generation devices are provided that can be used in combination to power various features in a toilet which will be particularly useful for portable potties that are off the grid. The power generation devices and methods include, for example, using a cell battery inside the toilet bowl or flush tank, a wind turbine, solar panels, and piezoelectricity. The features include, for example, lighting up the toilet with light-emitting diodes (LEDs) to make it easier for users to find the toilet, an audio/video setup for entertainment, and a toilet status light indicator to let the next user know when the toilet paper is out.Type: ApplicationFiled: November 8, 2018Publication date: May 14, 2020Inventors: Ganapathi Pamula, Shubham Mathur, Snehil Mathur, Vamsee Pamula
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Publication number: 20190154678Abstract: A point-of-birth system and instrument, biochemical cartridge, and methods for newborn screening is disclosed. Namely, a point-of-birth system is provided that includes a point-of-birth instrument for receiving and processing a biochemical cartridge for performing newborn screening. Further, a portable smart device, such as a smartphone or tablet, is in communication with point-of-birth instrument, wherein the smart device may include a newborn screening (NBS) mobile app. In one example, the point-of-birth system and point-of-birth instrument support newborn biological screening only. However, in another example, the point-of-birth system and point-of-birth instrument support both newborn biological screening and newborn physiological screening.Type: ApplicationFiled: May 1, 2017Publication date: May 23, 2019Applicant: Baebies, Inc.Inventors: Vamsee Pamula, Vijay Srinivasan, Bort Donovan
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Publication number: 20170241949Abstract: A droplet actuator for manipulating a fluid using an electrical field includes a droplet arranged on or over an electrode. The droplet includes a set of beads arranged substantially in a monolayer on or over a surface of the droplet actuator.Type: ApplicationFiled: March 28, 2017Publication date: August 24, 2017Inventors: Donovan Bort, Carrie Graham, Vamsee Pamula, Michael Pollack, Ramakrishna Sista, Vijay Srinivasan
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Publication number: 20160231268Abstract: The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads.Type: ApplicationFiled: April 14, 2016Publication date: August 11, 2016Applicants: ADVANCED LIQUID LOGIC, INC., Duke UniversityInventors: Vamsee Pamula, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair
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Publication number: 20150148238Abstract: The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads.Type: ApplicationFiled: January 30, 2015Publication date: May 28, 2015Applicants: ADVANCED LIQUID LOGIC, INC., Duke UniversityInventors: Vamsee Pamula, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair
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Publication number: 20150107995Abstract: The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads.Type: ApplicationFiled: January 5, 2015Publication date: April 23, 2015Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Ramakrishna Sista, Vamsee Pamula, Arjun Sudarsan, Vijay Srinivasan, Prasanna Thwar
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Patent number: 8927296Abstract: The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads.Type: GrantFiled: May 18, 2009Date of Patent: January 6, 2015Assignee: Advanced Liquid Logic, Inc.Inventors: Ramakrishna Sista, Vamsee Pamula, Arjun Sudarsan, Vijay Srinivasan, Prasanna Thwar
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Patent number: 8883513Abstract: The present invention relates to droplet-based particle sorting. According to one embodiment, a droplet microactuator is provided and includes: (a) a suspension of particles; and (b) electrodes arranged for conducting droplet operations using droplets comprising particles. A method of transporting a particle is also provided, wherein the method includes providing a droplet comprising the particle and transporting the droplet on a droplet microactuator.Type: GrantFiled: February 18, 2011Date of Patent: November 11, 2014Assignee: Advanced Liquid Logic, Inc.Inventors: Michael G. Pollack, Vamsee Pamula, Vijay Srinivasan
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Publication number: 20140174926Abstract: A method of mixing a droplet, the method comprising providing a droplet on a surface, forming the droplet into a first “U” shape having a bottom region and two terminal ends, and simultaneously merging the terminal ends and splitting the droplet at the bottom region to form a second “U” shape which is substantially opposite the first “U” shape.Type: ApplicationFiled: May 1, 2012Publication date: June 26, 2014Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Donovan Bort, Carrie Graham, Vamsee Pamula, Michael Pollack, Ramakrishna Sista, Vijay Srinivasan
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Publication number: 20140057363Abstract: The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads.Type: ApplicationFiled: May 18, 2009Publication date: February 27, 2014Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Ramakrishna Sista, Vamsee Pamula, Arjun Sudarsan, Vijay Srinivasan, Prasanna Thwar
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Patent number: 8658111Abstract: The present invention provides droplet actuators, modified fluids and methods relating to droplet operations. An aspect includes a droplet actuator including a droplet operations substrate; an oil based filler fluid on the droplet operations substrate comprising an oil soluble additive in the filler fluid; and a droplet in contact with the oil based filler fluid. Still other aspects are provided.Type: GrantFiled: February 22, 2011Date of Patent: February 25, 2014Assignee: Advanced Liquid Logic, Inc.Inventors: Vijay Srinivasan, Vamsee Pamula, Ramakrishna Sista, Arjun Sudarsan, Prasanna Thwar