Publication number: 20250115622
Abstract: Disclosed herein are crystalline forms of (4S,7aR,9aR,10R,11E,14S,15R)-6?-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3?,4?,7a,8,9,9a,10,13,14,15-decahydro-2?H,3H,5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1?-naphthalene]-16,16,18(7H,17H)-trione (AMG 397): (AMG 397), hydrates, and solvates thereof. Also disclosed are methods of making the crystalline forms, and methods of treating diseases and disorders with the crystalline forms.
Type:
Application
Filed:
February 3, 2023
Publication date:
April 10, 2025
Inventors:
Ron C. Kelly, Mary Chaves, Jing Teng, Stephan Parent, Markian Stec, Van Luu, Robert P. Farrell, James E. Huckle, Michal Achmatowicz, Tian Wu, Darren Leonard Reid, Lingyun Xiao