Abstract: Thereto a method and a system for planning radiation therapy are provided, as well as an arrangement for radiation therapy planning and a computer program product for carrying out the method. For planning the radiation therapy, the following steps are performed. Patient data of a subject to be treated is received as well as image data of the subject to be treated. The image data comprises anatomical image data of one or more organs at risk associated with the functioning of the immune system. Next, the patient 122 data and the image data are processed to obtain a risk score for the one or more organs at risk associated with the functioning of the immune system. The risk score is indicative of the risk of hematologic toxicity in the subject to be treated in response to the radiation therapy. Then the radiation therapy treatment is planned using the obtained risk score.

Abstract: Aspects and embodiments relate to a method and apparatus configured to perform that method. The method relates to generating an indication of relevance associated with a selected biological phenomenon indicative of condition of an immune system of a patient, that selected biological phenomenon being associated with response of a patient to a chosen therapy. The method comprises steps of: determining one or more measurable input parameters characteristic of the patient and associated with the biological phenomenon; mapping the one or more input parameters to a contribution to a score associated with the selected biological phenomenon; and combining the mapped contributions across the one or more input parameters to calculate the score associated with the selected biological phenomenon.

Abstract: The present invention relates to a device (100) for isolating an analyte (2) from a body fluid sample (4), wherein the analyte (2) is part of a target (6) contained in the body fluid sample (4). The device (100) comprises at least two types of magnetic particles (8, 12) for binding the analyte (2) and/or the target (6), at least three chambers (16, 18, 20) arranged in series to allow controlled movement of the magnetic particles (8, 12) and at least one fluid for releasing the analyte (2) from the target (6).

Abstract: A computer-implemented method for determining tumor heterogeneity is provided. Embodiments of the method involve analyzing a radiological image of a tumor to calculate a value indicative of tumor activity at each of a plurality of locations in the tumor; determining whether each calculated value is above a predetermined threshold; and calculating a heterogeneity score for the tumor; wherein the heterogeneity score is calculated based on a volume fraction of the tumor having a value indicative of tumor activity above the predetermined threshold. Also provided are associated systems and computer program products.

Abstract: A method of generating a strategy for performing a radiotherapy-based treatment and a system for performing the method. During a radiotherapy-based treatment, characteristics of side-effects are monitored and a risk model of the subject modified based on the characteristics. A new treatment strategy for the radiotherapy-based treatment is obtained based on the modified risk model.

Abstract: Described is a computer-implemented method for determining a risk of hematologic toxicity in a subject to be treated with radiotherapy. The method involves processing treatment data including a prescribed dose of radiation for the subject and imaging data displaying radiation- sensitive tissues such as bone marrow and/or lymphoid organs in the subject to determine a received dose of radiation to be delivered to the radiation-sensitive tissues. The method further comprises processing patient data such as blood cell counts and the received dose of radiation to obtain a risk of hematologic toxicity in the subject in response to the radiotherapy. Also provided is a system and computer program product for performing the method.

Abstract: A method of generating a strategy for performing a radiotherapy-based treatment and a system for performing the method. During a radiotherapy-based treatment, characteristics of side-effects are monitored and a risk model of the subject modified based on the characteristics. A new treatment strategy for the radiotherapy-based treatment is obtained based on the modified risk model.

Abstract: A computerized system for monitoring cancer therapy and a related method. The system comprises an input port (IN) for receiving two or more input images acquired of a subject, the two or more input images capable of recording metabolic activity and extracellular pH level. An evaluator (EVAL) of the system is configured to assess, based on the input images, i) a change over time in metabolic activity and ii) a change over time in extracellular pH level. The evaluator (EVAL) is further configured to establish, based on the assessment, an indication on whether or not there is a response to a cancer therapy in relation to a lesion of the subject or on whether the assessment is inconclusive. The indication is output through an output interface (OUT).

Abstract: A clinical decision support system (100) is disclosed. The clinical decision support system (100) comprises a processor (102) configured to: establish a subject profile for defining a subject according to a plurality of features; identify a set of clinical trials that are relevant to the subject, wherein each clinical trial in the set of relevant clinical trials corresponds to at least one therapy has inclusion criteria that are satisfied by features of the plurality of features of the subject profile; rank the therapies corresponding to the relevant clinical trials; and output the ranking of the therapies for the subject. A method and a computer program product are also disclosed.

Abstract: The present invention relates to a device (100) for isolating an analyte (2) from a body fluid sample (4), wherein the analyte (2) is part of a target (6) contained in the body fluid sample (4). The device (100) comprises at least two types of magnetic particles (8, 12) for binding the analyte (2) and/or the target (6), at least three chambers (16, 18, 20) arranged in series to allow controlled movement of the magnetic particles (8, 12) and at least one fluid for releasing the analyte (2) from the target (6).

Abstract: The present invention relates to a device, system and method for managing treatment of an inflammatory autoimmune disease of a person. The proposed device comprises an input unit (20) for receiving measurement data acquired over time including white blood cell count data related to the person's white blood cell count, tumor necrotic factor-? data related to the person's tumor necrotic factor-?, C-reactive protein data related to the person's C-reactive protein, cortisol level data related to the person's cortisol level and melatonin data related to the person's melatonin concentration. The device further comprises a treatment manager (21) for managing treatment of the inflammatory autoimmune disease of the person by combining the obtained measurement data by an algorithm to obtain a disease activity level, to monitor the disease activity level over time and to determine treatment interventions based on the monitored disease activity level.

Abstract: The present invention relates to a device, system and method for detecting illness- and/or therapy-related fatigue of a person in an easy and reliable way. For this purpose the device comprises an input unit (20) for obtaining white blood cell count data related to the person's white blood cell count, hemoglobin level data related to the person's hemoglobin level and cortisol level data related to the person's cortisol level, and an analyzer (21) for detecting illness- and/or therapy-related fatigue of the person based on the obtained white blood cell count data, hemoglobin level data and cortisol level data.