Abstract: The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Embodiments disclosed are directed to systems and methods for modifying an electronic circuit design. According to embodiments, the method includes generating a circuit element of an electronic circuit layout on a graphical user interface, and generating an array group including a plurality of circuit elements. Each cell of the array group includes the same circuit element, and the array group is generated such that a change in at least one attribute of the array group is applied to each circuit element of the plurality of circuit elements.

Abstract: Provided herein are methods and compositions for the treatment of myopathies.

Abstract: The present embodiments relate to providing an overlap view of external and internal components of all instance circuit cells related to a master circuit cell in a same layout view. A layout of a circuit having a plurality of instance circuit cells of a master circuit cell is provided. Further, a graphical user interface including a user selectable option for an overlay view is provided. In addition, responsive to the selection of the overlay view, the plurality of instance circuit cells of the master circuit cell is determined. In addition, a plurality of sets of circuit elements, each set of circuit elements including external circuit elements that overlap with a corresponding instance circuit cell of the plurality of instance circuit cells is determined. Further, the plurality of sets of circuit elements overlaid on the master circuit cell is displayed on the layout view.

Abstract: The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Provided herein are methods and compositions for the treatment of myopathies.

Abstract: The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A method for using mobile device roaming data to determine consumer geolocation for use in authorization decisions includes: storing an account profile, the profile including data related to a transaction account associated with a cardholder including an account identifier and geographic location; receiving a location notification, the notification including the account identifier and an updated geographic location of the cardholder, the updated geographic location being identified based on roaming data associated with a mobile communication device associated with the cardholder; receiving an authorization request associated with a payment transaction, the authorization request being a transaction message formatted based on associated standards and including the account identifier, transaction data, and a transaction location; determining an authorization decision for the payment transaction based on a correspondence between the updated geographic location and the transaction location; and forwarding the rece

Abstract: An apparatus, system, and method are disclosed for selecting optimal replica sources in a grid computing environment. As disclosed, the present invention overcomes shortcomings in the art involving location and selection of replica sources. In particular, the present invention selects an optimal replica source based on current and historical network statistics, as well as user-defined policies. The user-defined policies allow for customization of the replica source search, and the option of obtaining multiple ranked sources for parallel data transfer.

Abstract: A circuit design process is presented that includes a block placement operation, followed by global routing based upon the initial placement of the blocks. Congestion data is generated from the global routing and, in an automated process, the blocks are placed again based upon the congestion data to reduce the routing congestion of the design. This can be used as part of a custom layout design process, for example.

Abstract: A circuit design process for the reduction of routing congestion is described. This process includes a block placement operation, an initial pin optimization for the block placement, and global routing based upon the initial pin optimization. Congestion data is generated from the global routing and, in an automated process, the pins are re-optimized, based upon the congestion data. This process can be used as part of a custom layout design process, for example.

Abstract: An apparatus, system, and method are disclosed for selecting optimal replica sources in a grid computing environment. As disclosed, the present invention overcomes shortcomings in the art involving location and selection of replica sources. In particular, the present invention selects an optimal replica source based on current and historical network statistics, as well as user-defined policies. The user-defined policies allow for customization of the replica source search, and the option of obtaining multiple ranked sources for parallel data transfer.

Abstract: A replication server accessible via a web browser provides high-level replication services and replication-related services to a user by leveraging low-level file transfer and replica location services associated with a grid. In one embodiment, a set of graphical user interfaces enables a user to edit attributes associated with a data file, replicate a set of data files such as a directory, publish data files to the replica location service, delete one or more data files, search for files with specific attributes, and conduct replication operations on search results. The aforementioned functionality is provided while maintaining the integrity of information maintained by the replica location services.