Abstract: The present disclosure provides, inter alia, pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. In certain embodiments, the pharmaceutical compositions contain nonabsorbable compositions and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons, the conjugate base of a strong acid and/or a strong acid from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human. In certain embodiments, compositions for and methods of improving the quality of life and/or physical function score of such patients are also provided. In certain embodiments, compositions for and methods of slowing the progression of kidney disease in such patients are also provided.

Abstract: Provided herein are methods and compositions for the treatment of myopathies.

Abstract: A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.

Abstract: In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.

Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.

Abstract: An acrylic acid polymer having a weight average molecular weight Mw in the range from 3500 to 2000 g/mol and a polydispersity index Mw/Mn?2.5, wherein 30% to 60% of the acid groups of the acrylic acid polymers have been neutralized with calcium ions, 30% to 70% of the acrylic acid polymers have been neutralized with sodium ions and 0% to 10% of the acid groups of the acrylic acid polymers have not been neutralized.

Abstract: A system for bioprocessing includes a tray having plurality of sidewalls and a bottom surface defining an interior compartment, and a generally open top, and an opening formed in the bottom surface of the tray, the opening having a perimeter. The perimeter of the opening is shaped and/or dimensioned such that a bioreactor vessel can be positioned above the opening and supported by the bottom surface of the tray while a portion of the bioreactor vessel is accessible through the opening in the bottom surface. The tray is receivable within a processing chamber such that the bed plate extends through the opening in the bottom surface of the tray to support the bioreactor vessel.

Abstract: A bioprocessing method for cell therapy includes the steps of genetically modifying a population of cells in a bioreactor vessel to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the bioreactor vessel to generate a number of genetically modified cells sufficient for one or more doses for use in a cell therapy treatment without removing the population of genetically modified cells from the bioreactor vessel. Cells are settled on a gas permeable, liquid impermeable membrane for expansion, and are resuspended when, or after, the desired cell density is reached.

Abstract: A hollow extension tube or extension assembly aids in increasing the quantity of any inhaled or aerosolized substance delivered to a patient's lungs from an inhaler or source. The length of the extension tube reduces the velocity and increases the temperature of the aerosolized substance, easing inhalation. The interior surface of the hollow extension tube has anti-static properties which reduces the amount of aerosolized substance trapped by the interior surface of the hollow extension tube. The interior surface of the extension tube may be formed of cardboard.

Abstract: A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removi

Abstract: In one embodiment, a method includes creating a catalog of service function (“SF”) profiles, wherein each of the profiles is associated with an SF and indicates a type of the associated SF; storing the catalog of SF profiles in a memory device of a service controller associated with the DVS; creating a service profile group template (“SPGT”) that includes at least one SF profile from the catalog of SF profiles, wherein the SPGT includes a service chain definition identifying at least one service chain comprising the SF associated with the at least one SF profile to be executed in connection with a service path and at least one policy for classifying traffic to the at least one service chain; deploying a first SPG instance based on the SPGT; and deploying an additional SPG instance based on the SPGT in accordance with a scaling policy included in the SPGT.

Abstract: Selectively controlling transmit power from a radio access network (RAN) cell to user equipment (UE) in closed-loop power control for uplink control channel based on variation in measured uplink signal quality. To avoid the RAN cell continuously sending transmit power control messages that may not be effective in further adjusting transmit power of the UE, the RAN cell selectively controls transmit power of the UE based on effectiveness in such transmit power control changing uplink channel signal quality. The determined effectiveness of the transmit power control can be used by the RAN cell to determine when the next transmit power control message should be sent to the UE. The RAN cell can be configured to indirectly measure the uplink channel power by reviewing the received uplink channel quality in a report communicated from the UE to the RAN cell.

Abstract: A fixed-width pulse generator includes a metastability detector circuit, a delay signal generator, and a combinational logic circuit. The metastability detector circuit is configured to receive a trigger signal and generate state detection signals. The delay signal generator is configured to receive the state detection signals and the trigger signal, and delay the trigger signal by two different delay values to generate two different delayed signals. One of the delay values is based on the state detection signals. The combinational logic circuit is configured to receive the two delayed signals and an error signal, and generate a fixed-width pulse that remains constant over process, voltage, and temperature variations.

Abstract: Applications of dielectric barrier discharge (DBD) based atmospheric pressure plasma jets are often limited by the relatively small area of treatment due to their 1D configuration. This system generates 2D plasma jets permitting fast treatment of larger targets. DBD evolution starts with formation of transient anode glow, and continues with development of cathode-directed streamers. The anode glow can propagate as an ionization wave along the dielectric surface through and outside of the discharge gap. Plasma propagation is not limited to 1D geometry such as tubes, and can be organized in a form of a rectangular plasma jet, or other 2D or 3D shapes. Also described are a method for generating 2D plasma jets and use of the 2D plasma jets for cancer therapy.

Abstract: A mechanism is provided for implement a discrepancy detection mechanism for detecting discrepancies between clinical notes and administrative records. Clinical concepts are extracted from the clinical notes and the administrative records in a patient's electronic medical records (EMRs). The extracted clinical concepts are filtered based on semantic type information to identify concepts that reference diseases or syndromes while also removing negated instances. Utilizing the positive mentions of diseases in clinical notes, the positive mentions of diseases or syndromes in the clinical notes are compared against each positive entry in the administrative records. A discrepancy summary is then generated for diseases or syndromes that failed to translate correctly from clinical notes to the administrative records in the patient's EMRs.

Abstract: A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removi

Abstract: A non-transitory computer readable medium includes instructions configured to adapt a controller to maintain a first target environment in a bioreactor vessel containing a population of cells for a first incubation period to produce a population of genetically modified cells from the population of cells, initiate a flow of media to the bioreactor vessel, maintain a second target environment in the bioreactor vessel for a second incubation period to produce an expanded population of genetically modified cells.

Abstract: A device performs registering with a first access network to generate a first registration, detecting a triggering event, and registering with a second access network to generate a second registration while maintaining the first registration with the first access network.

Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.

Abstract: A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.