Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: The invention regards a method for electrochemical ammonia synthesis, comprising the steps of: —providing an electrolysis cell having a cathode, —contracting the cathode with a source of cations preferably lithium cations, a source of nitrogen a source of oxygen, and a source of protons, wherein the oxygen source provides a predefined oxygen concentration, and —subjecting the cell to a potential and current load, whereby ammonia is synthesized.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: A system and method are provided for providing advisory notifications to mobile applications. The method includes interfacing the server device with at least one endpoint within an enterprise system and storing a model trained by a machine learning engine to automatically determine advisory notifications relevant to client data sets stored by the endpoint(s) and/or the at least one endpoint. The method also includes determining a current state of a client account, using the model to determine an advisory notification for the client account based on the current state, referring to a set of rules to determine when to provide the advisory notification in the mobile application, and in what portion of the mobile application to display the notification; and sending the advisory notification via the communications module to a client device to display the advisory notification in the mobile application.

Abstract: Systems and methods for allocating resources. The system includes a communications module, a processor, and a memory. The memory stores a data record and instructions that, when executed, configure the processor to obtain a data record and transmit an existing score indication corresponding to the data record for display at the client device; receive a first time parameter and an action indicator associated with a shared resource and, in response, determine a first provisional score corresponding to the data record based on the existing score indication, the action indicator, and the first time parameter to provide a first provisional score indication; transmit the first provisional score indication and a selectable option associated with the action indicator for display at the client device while the first provisional score indication is displayed; and in response to receiving a resource transfer instruction, allocate the shared resource associated with the action indicator.

Abstract: Systems and methods for allocating resources. The system includes a communications module, a processor, and a memory. The memory stores a data record and instructions that, when executed, configure the processor to obtain a data record and transmit an existing score indication corresponding to the data record for display at the client device; receive a first time parameter and an action indicator associated with a shared resource and, in response, determine a first provisional score corresponding to the data record based on the existing score indication, the action indicator, and the first time parameter to provide a first provisional score indication; transmit the first provisional score indication and a selectable option associated with the action indicator for display at the client device while the first provisional score indication is displayed; and in response to receiving a resource transfer instruction, allocate the shared resource associated with the action indicator.

Abstract: Systems and methods for allocating resources. The system includes a communications module, a processor, and a memory. The memory stores a data record and instructions that, when executed, configure the processor to obtain a data record and transmit an existing score indication corresponding to the data record for display at the client device; receive a first time parameter and an action indicator associated with a shared resource and, in response, determine a first provisional score corresponding to the data record based on the existing score indication, the action indicator, and the first time parameter to provide a first provisional score indication; transmit the first provisional score indication and a selectable option associated with the action indicator for display at the client device while the first provisional score indication is displayed; and in response to receiving a resource transfer instruction, allocate the shared resource associated with the action indicator.

Abstract: Described herein is a scalable, economic, energy and time efficient method for the synthesis of a crystalline uniform nanoporous oxide material by utilizing colloidal particles in solution combustion synthesis. By removing colloids from nanocomposite via chemical etching crystalline uniform porous oxide is prepared with tailored porosity. The produced oxides have high specific surface area, high pore volume, uniform pore structure and high crystallinity. Properties of the oxide can be tuned by the concentration and size of colloids added, which affects the porous structure (mesopore diameter, pore wall thickness, surface area, and pore volume). In principle, this method can be applied to synthesize different high porosity crystalline metal oxides and nanocomposites.

Abstract: A versatile, highly scalable single step method is provided for depositing a metallic Pd film from low temperature combustion of an aqueous solution. By using only palladium nitrate and glycine as precursors, water as a solvent, mirror-bright dense Pd films with high crystallinity and good adhesion can be deposited at 250° C. on different substrates without subsequent annealing. The technique can be used to form a reusable catalytic flask as illustrated by the Suzuki-Miyaura cross-coupling reaction, where the Pd film uniformly covers the inner walls of the flask and eliminates the catalyst separation step.

Abstract: Systems and methods for allocating resources. The system includes a communications module, a processor, and a memory. The memory stores a data record and instructions that, when executed, configure the processor to obtain a data record and transmit an existing score indication corresponding to the data record for display at the client device; receive a first time parameter and an action indicator associated with a shared resource and, in response, determine a first provisional score corresponding to the data record based on the existing score indication, the action indicator, and the first time parameter to provide a first provisional score indication; transmit the first provisional score indication and a selectable option associated with the action indicator for display at the client device while the first provisional score indication is displayed; and in response to receiving a resource transfer instruction, allocate the shared resource associated with the action indicator.

Abstract: Described herein is a scalable, economic, energy and time efficient method for the synthesis of a crystalline uniform nanoporous oxide material by utilizing colloidal particles in solution combustion synthesis. By removing colloids from nanocomposite via chemical etching crystalline uniform porous oxide is prepared with tailored porosity. The produced oxides have high specific surface area, high pore volume, uniform pore structure and high crystallinity. Properties of the oxide can be tuned by the concentration and size of colloids added, which affects the porous structure (mesopore diameter, pore wall thickness, surface area, and pore volume). In principle, this method can be applied to synthesize different high porosity crystalline metal oxides and nanocomposites.