Patents by Inventor Vara Prasad Josyula

Vara Prasad Josyula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OR2L13 AGONISTS TO TREAT CVD WITH DYSREGULATED PLATELET ACTIVATION
    Publication number: 20240108591
    Abstract: Provided herein are compositions, systems, and methods for treating a subject with, or elevated risk for, a cardiovascular disease (CVD) involving dysregulated platelet activation comprising: treating the subject with a composition comprising an OR2L13 activating agent (e.g., carvone; 2-tert-Butyl-4-Methylphenol; or 2-tert-Butyl-5-Methylphenol). In certain embodiments, the CVD comprises abdominal aortic aneurysm (AAA) or thrombosis.
    Type: Application
    Filed: July 14, 2023
    Publication date: April 4, 2024
    Inventors: Shaun Stauffer, Scott Cameron, Vara Prasad Josyula
  • ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL- OXAZOLIDINONE DERIVATIVES AND ANALOGUES
    Publication number: 20080090884
    Abstract: The present invention provides certain [3.1.0]bicyclic oxazolidinone derivatives of Formula I I or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Application
    Filed: October 5, 2007
    Publication date: April 17, 2008
    Inventors: Adam Renslo, Mikhail Gordeev, Dinesh Patel, Hongwu Gao, Vara Prasad Josyula
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Patent number: 7179918
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: February 20, 2007
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stacie S. Canan Koch, Therese N. Alexander, Benjamin J. Burke, Tanya M. Jewell, David J. Kucera, Maria Angelica Linton, Lennert J. Mitchell, Jr., Siegfried H. Reich, Donald J. Skalitzky, John H. Tatlock, Michael D. Varney, Scott C. Virgil, Stephen E. Webber, Stephen T. Worland, Mark Barvian, Gary Bolton, Frederick Earl Boyer, Jr., Jeffrey J. Machak, Tod Holler, Sean T. Murphy, Michael Melnick, Vara Prasad Josyula
  • Oxindole oxazolidinone as antibacterial agent
    Publication number: 20060229348
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. The compound is useful as antibacterial agents.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 12, 2006
    Inventors: Vara Prasad Josyula, Gary Luehr, Mikhail Gordeev
  • 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
    Publication number: 20060229349
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. These compounds are useful as antibacterial agents.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 12, 2006
    Inventors: Vara Prasad Josyula, Mikhail Gordeev, Gary Luehr
  • Oxazolidinones containing oxindoles as antibacterial agents
    Publication number: 20060030609
    Abstract: The present invention relates to novel oxazolidinones derivatives of oxindoles of formula I, or a pharmaceutically acceptable salt thereof wherein Y1 is —CH— or —CF—; R1 is —C1-4alkyl, optionally substituted with a fluoro atom, or R1 is —C3-5cycloalkyl; and R2 is —H or —CH3. These compounds are useful as antibacterial agents.
    Type: Application
    Filed: July 28, 2005
    Publication date: February 9, 2006
    Inventors: Gary Luehr, Rama Jain, Adam Renslo, Vara Prasad Josyula, Mikhail Gordeev
  • Acyloxymethylcarbamate prodrugs of oxazolidinones
    Publication number: 20050267104
    Abstract: The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.
    Type: Application
    Filed: September 9, 2004
    Publication date: December 1, 2005
    Inventors: Vara Prasad Josyula, Robert Gadwood, Lisa Thomasco, Ji-Young Kim, Allison Choy, Frederick Boyer
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Patent number: 6953858
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: October 11, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Stacie S. Canan Koch, Therese N. Alexander, Mark Barvian, Gary Bolton, Frederick Earl Boyer, Jr., Benjamin J. Burke, Tod Holler, Tanya M. Jewell, Vara Prasad Josyula, David J. Kucera, Maria Angelica Linton, Jeffrey J. Machak, Lennert J. Mitchell, Jr., Sean T. Murphy, Siegfried H. Reich, Donald J. Skalitzky, John H. Tatlock, Michael D. Varney, Scott C. Virgil, Stephen E. Webber, Stephen T. Worland, Michael Melnick
  • Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
    Publication number: 20050192325
    Abstract: The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Application
    Filed: April 1, 2004
    Publication date: September 1, 2005
    Inventors: Adam Renslo, Mikhail Gordeev, Dinesh Patel, Hongwu Gao, Vara Prasad Josyula
  • Antibacterial agents
    Publication number: 20050070523
    Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications, including using the invention compounds to treat bacterial infections.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 31, 2005
    Inventors: Susan Hagen, Vara Prasad Josyula
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Publication number: 20030225071
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 11, 2002
    Publication date: December 4, 2003
    Inventors: Stacie S. Canan Koch, Therese N. Alexander, Mark Barvian, Gary Bolton, Fredrick E. Boyer, Benjamin J. Burke, Tod Holler, Tanya M. Jewell, Vara Prasad Josyula, David J. Kucera, Maria A. Linton, Jeffrey J. Machak, Lennert J. Mitchell, Sean T. Murphy, Siegfried H. Reich, Donald J. Skalitzky, John H. Tatlock, Michael D. Varney, Scott C. Virgil, Stephen E. Webber, Stephen T. Worland, Michael Melnick
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Publication number: 20030153507
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 11, 2002
    Publication date: August 14, 2003
    Inventors: Stacie S. Canan-Koch, Therese N. Alexander, Mark Barvian, Gary Bolton, Frederick E. Boyer, Benjamin J. Burke, Tod Holler, Tanya M. Jewell, Vara Prasad Josyula, David J. Kucera, Maria A. Linton, Jeffrey J. Machak, Lennert J. Mitchell, Sean T. Murphy, Siegfried H. Reich, Donald J. Skalitzky, John H. Tatlock, Michael D. Varney, Scott C. Virgil, Stephen E. Webber, Stephen T. Worland, Michael Melnick