Patents by Inventor Varghese John

Varghese John has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N,N?-substituted-1,3-diamino-2-hydroxypropane derivatives
    Patent number: 7727997
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealey, Ruth Tenbrink, Larry Fang, Roy Hom
  • eAPP AND DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20100099609
    Abstract: This invention provides methods of reducing levels of amyloid beta (A?) protein and/or netrin-1 in a mammal. In certain embodiments the methods involve administering to the mammal a fragment of an amyloid precursor protein, or a mutant amyloid precursor protein, in an amount sufficient to decrease circulating levels of free A? protein in said mammal, wherein said fragment is a fragment of the extracellular domain of APP or a mutant thereof that binds amyloid beta protein and/or netrin-1.
    Type: Application
    Filed: July 28, 2009
    Publication date: April 22, 2010
    Applicant: BUCK INSTITUTE FOR AGE RESEARCH
    Inventors: VARGHESE JOHN, CLARE PETERS-LIBEU, DALE E. BREDESEN
  • Acetyl 2-hydroxy-1, 3-diaminoalkanes
    Patent number: 7645780
    Abstract: Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: January 12, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth T. TenBrink
  • SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS
    Publication number: 20090270367
    Abstract: The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 3, 2009
    Publication date: October 29, 2009
    Inventors: Varghese JOHN, Michel MAILLARD, John TUCKER, Jose AQUINO, Barbara JAGODZINSKA, Louis BROGLEY, Jay TUNG, Simeon BOWERS, Darren DRESSEN, Gary PROBST, Neerav SHAH
  • Compounds to treat Alzheimer's disease
    Patent number: 7553831
    Abstract: The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: June 30, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: James Beck, Andrea Gailunas, Roy Hom, Barbara Jagodinska, Varghese John, Michael Maillaird
  • 2-amino- and 2-thio- substituted 1,3-diaminopropanes
    Patent number: 7544717
    Abstract: Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: June 9, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, John Tucker, Varghese John, Neerav Shah
  • Beta-secretase enzyme compositions and methods
    Publication number: 20090144840
    Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.
    Type: Application
    Filed: August 14, 2008
    Publication date: June 4, 2009
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: John P. Anderson, Guriqbal Basi, Minh Tam Doan, Normand Frigon, Varghese John, Michael Power, Sukanto Sinha, Gwen Tatsuno, Jay Tung, Shuwen Wang, Lisa McConlogue
  • ?-secretase enzyme compositions and methods
    Patent number: 7514408
    Abstract: Disclosed is an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (APP and APPsw) are also disclosed. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: April 7, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Sukanto Sinha, Jay S. Tung
  • Compounds to treat alzheimer's disease
    Publication number: 20090074746
    Abstract: The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: September 24, 2004
    Publication date: March 19, 2009
    Inventors: Lawrence Y. Fang, Roy Hom, Varghese John, Michel Maillard
  • Substituted hydroxyethylamines
    Patent number: 7498436
    Abstract: This present invention relates to prodrug compounds of the formula (Y) and pharmaceutical salts thereof: where RN, R1, R2, R3R4 and RC are defined herein, which are useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: March 3, 2009
    Assignees: Pharmacia & Upjohn Company LLC, Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Barbara Jagodzinska, Michel Maillard, James P. Beck, Ruth E. TenBrink, Daniel Getman
  • OXIME DERIVATIVE SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS
    Publication number: 20090042961
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: May 8, 2008
    Publication date: February 12, 2009
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, Jose Aquino, Gary Probst, Jay Tung
  • Lactam compound
    Patent number: 7468365
    Abstract: The present invention provides crystalline (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, a crystalline anydrate and dihydrates thereof, compositions comprising (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, its crystalline anhydrate or dihydrate, and methods for using the same.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: December 23, 2008
    Assignees: Eli Lilly and Company, Elan
    Inventors: James Edmund Audia, Benjamin Alan Diseroad, Varghese John, Lee H. Latimer, Jeffrey Scott Nissen, Gregory Alan Stephenson, Eugene D. Thorsett, Jay S. Tung
  • Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
    Patent number: 7459476
    Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) wherein X, R1, and R2 are defined herein.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: December 2, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventor: Varghese John
  • ?-secretase enzyme compositions and methods
    Patent number: 7456007
    Abstract: Disclosed is an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (APP and APPsw) are also disclosed. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.
    Type: Grant
    Filed: December 24, 1999
    Date of Patent: November 25, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: John P. Anderson, Guriqbal Basi, Minh Tam Doan, Normand Frigon, Varghese John, Michael Power, Sukanto Sinha, Gwen Tatsuno, Jay Tung, Shuwen Wang, Lisa McConlogue
  • Benzamide 2-hydroxy-3-diaminoalkanes
    Publication number: 20080249139
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: May 30, 2007
    Publication date: October 9, 2008
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Compounds for the treatment of Alzheimer's disease
    Patent number: 7432389
    Abstract: The present invention is substituted amine s of formula (XV) useful in treating Alzheimer's ease and other similar disease.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: October 7, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Lawrence Fang, Varghese John
  • Beta-secretase enzyme compositions and methods
    Patent number: 7427478
    Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: September 23, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: John P. Anderson, Guriqbal Basi, Minh Tam Doan, Normand Frigon, Varghese John, Michael Power, Sukanto Sinha, Gwen Tatsuno, Jay Tung, Shuwen Wang, Lisa McConlogue
  • Phenacyl 2-Hydroxy-3-Diaminoalkanes
    Publication number: 20080207696
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: November 21, 2007
    Publication date: August 28, 2008
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Methods of Treatment of Amyloidosis Using Subsituted Ethanolcyclicamine Aspartyl Protease Inhibitors
    Publication number: 20080166332
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis.
    Type: Application
    Filed: August 26, 2005
    Publication date: July 10, 2008
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Roy Hom, Lawrence Fang, Varghese John
  • Device for multicentric brain modulation, repair and interface
    Publication number: 20080154331
    Abstract: A brain stimulation device, including: a cranial chip that is configured to be surgically implanted between a patient's scalp and skull; at least three stimulation leads connected to the cranial chip, wherein each lead has a plurality of stimulation electrodes thereon; control circuitry in the cranial chip for controlling the operation of the stimulation leads and stimulation electrodes; and a power source in the cranial chip for powering the simulation leads and the stimulation electrodes and the control circuitry.
    Type: Application
    Filed: December 21, 2006
    Publication date: June 26, 2008
    Inventors: Varghese John, Douglas S. Kondziolka