Patents by Inventor Varsha Shukla

Varsha Shukla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic approach to neurodegenerative disorders using a TFP5-peptide
    Patent number: 8597660
    Abstract: Disclosed herein are isolated peptides, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer's. In an example, an isolated polypeptide includes a cyclin dependent kinase 5 (Cdk5) inhibitory domain that has at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, wherein the Cdk5 inhibitory domain is linked to a protein transduction domain. Methods of reducing or inhibiting one or more symptoms associated with a neurodegenerative disease by administering a therapeutically effective amount of a pharmaceutical composition including one or more disclosed peptides are also provided.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: December 3, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Harish C. Pant, Ya-li Zheng, Niranjana D. Amin, Philip Grant, Parvathi Rudrabhatla, Varsha Shukla, Sashi Kesavapany
  • THERAPEUTIC APPROACH TO NEURODEGENERATIVE DISORDERS USING A TFP5-PEPTIDE
    Publication number: 20120115790
    Abstract: Disclosed herein are isolated peptides, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer's. In an example, an isolated polypeptide includes a cyclin dependent kinase 5 (Cdk5) inhibitory domain that has at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, wherein the Cdk5 inhibitory domain is linked to a protein transduction domain. Methods of reducing or inhibiting one or more symptoms associated with a neurodegenerative disease by administering a therapeutically effective amount of a pharmaceutical composition including one or more disclosed peptides are also provided.
    Type: Application
    Filed: September 29, 2011
    Publication date: May 10, 2012
    Inventors: Harish C. Pant, Ya-li Zheng, Niranjana D. Amin, Philip Grant, Parvathi Rudrabhatla, Varsha Shukla, Sashi Kesavapany